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. 1976 May;29(5):403–410. doi: 10.1136/jcp.29.5.403

Classification of smooth muscle autoantibodies detected by immunofluorescence.

G F Bottazzo, A Florin-Christensen, A Fairfax, G Swana, D Doniach, U Groeschel-Stewart
PMCID: PMC476077  PMID: 777046

Abstract

Three hundred and twelve sera containing antibodies to smooth muscle (SMA) wer analysed for the immunofluorescence patterns they produced in various tissues. A classification is described based on the three main appearances in rat kidney. Some sera, mainly of low titre, reacted only with vessel walls (SMA-V), some stained vessels and renal glomeruli (SMA-G) and high titre sera, mainly from patients with chronic active hepatitis stained vessels, glomeruli, and intracellular fibrils in renal tubules (SMA-T). Peripheral staining in hepatocytes or thyroid cells was not a regular feature. 41/43 polyclonal SMA-T and -G sera were absorbed out completely by actin, and this also removed the pericullular staining in liver and thyroid when present. High titre SMA-V antibodies could not be absorbed by actin, and the antigen remains to be identified.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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