Abstract
Jejunal lamina propria plasma cells and eosinophils and intraepithelial lymphocytes were raised in coeliac children on gluten-containing diets, but only intraepithelial lymphocytes were increased in patients on gluten-free diets. In contrast, lamina propria lymphocytes were reduced in children with coeliad disease on gluten-containing diets but were normal in paitents on gluten-free diets. In children with coeliac disease who were studied serially, lamina propria plasma cells and eosinophils and intraepithelial lymphocytes increased, and lamina propria lymphocytes decreased, within three months of the reintroduction of gluten to the diet. These observations are essentially similar to those made in the adult form of the disease and suggest that more than one type of immunological reaction is involved in the pathogenesis of the jejunal lesion.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Douglas A. P., Crabbé P. A., Hobbs J. R. Immunochemical studies on the serum, intestinal secretions and intestinal mucosa in patients with adult celiac disease and other forms of the celiac syndrome. Gastroenterology. 1970 Sep;59(3):414–425. [PubMed] [Google Scholar]
- Ferguson A., Murray D. Quantitation of intraepithelial lymphocytes in human jejunum. Gut. 1971 Dec;12(12):988–994. doi: 10.1136/gut.12.12.988. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Holmes G. K., Asquith P., Stokes P. L., Cooke W. T. Cellular infiltrate of jejunal biopsies in adult coeliac disease in relation to gluten withdrawal. Gut. 1974 Apr;15(4):278–283. [PMC free article] [PubMed] [Google Scholar]
- Kay A. B. Studies on eosinophil leucocyte migration. II. Factors specifically chemotactic for eosinophils and neutrophils generated from guinea-pig serum by antigen-antibody complexes. Clin Exp Immunol. 1970 Nov;7(5):723–737. [PMC free article] [PubMed] [Google Scholar]
- Lancaster-Smith M., Kumar P. J., Dawson A. M. The cellular infiltrate of the jejunum in adult coeliac disease and dermatitis herpetiformis following the reintroduction of dietary gluten. Gut. 1975 Sep;16(9):683–688. doi: 10.1136/gut.16.9.683. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Montgomery R. D., Shearer A. C. The cell population of the upper jejunal mucosa in tropical sprue and postinfective malabsorption. Gut. 1974 May;15(5):387–391. doi: 10.1136/gut.15.5.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Pettingale K. W. Immunoglobulin-containing cells in the coeliac syndrome. Gut. 1971 Apr;12(4):291–296. doi: 10.1136/gut.12.4.291. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Savilahti E. Intestinal immunoglobulins in children with coeliac disease. Gut. 1972 Dec;13(12):958–964. doi: 10.1136/gut.13.12.958. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Shiner M., Ballard J. Antigen-antibody reactions in jejunal mucosa in childhood coeliac disease after gluten challenge. Lancet. 1972 Jun 3;1(7762):1202–1205. doi: 10.1016/s0140-6736(72)90924-5. [DOI] [PubMed] [Google Scholar]
- Shiner M. Ultrastructural changes suggestive of immune reactions in the jejunal mucosa of coeliac children following gluten challenge. Gut. 1973 Jan;14(1):1–12. doi: 10.1136/gut.14.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stewart J. S., Pollock D. J., Hoffbrand A. V., Mollin D. L., Booth C. C. A study of proximal and distal intestinal structure and absorptive function in idiopathic steatorrhoea. Q J Med. 1967 Jul;36(143):425–444. [PubMed] [Google Scholar]
- Weetman A. P., Haggith J., Douglas A. P. Proceedings: Enteric loss of lymphocytes in coeliac disease and in Crohn's disease. Gut. 1974 Oct;15(10):823–823. [PubMed] [Google Scholar]