Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1976 Jul;29(7):626–633. doi: 10.1136/jcp.29.7.626

Hepatic lesions in patients treated with synthetic anabolic steriods.

E C Sweeney, D J Evans
PMCID: PMC476130  PMID: 185239

Abstract

Hepatic abnormalities are described in three patients who received synthetic anabolic steroids. A child with Franconi's anaemia was treated for four years and at necropsy the liver showed generalized hyperplasia, hyperplastic nodules, and a benign hepatoma. Two adults received only three months' therapy with synthetic androgens; in one there was generalized hepatic hyperplasia and in the other widespread nodular hyperplasia. It is suggested that anabolic steroids may induce tumours through intermediate hyperplastic lesions, a sequence similar to that seen during tumour induction by carcinogens in experimental animals.

Full text

PDF
626

Images in this article

627Image
on p.627
628Image
on p.628
628Image
on p.628
629Image
on p.629
629Image
on p.629
630Image
on p.630
631Image
on p.631
631Image
on p.631
632Image
on p.632
632Image
on p.632

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bernstein M. S., Hunter R. L., Yachnin S. Hepatoma and peliosis hepatis developing in a patient with Fanconi's anemia. N Engl J Med. 1971 May 20;284(20):1135–1136. doi: 10.1056/NEJM197105202842006. [DOI] [PubMed] [Google Scholar]
  2. Blendis L. M., Parkinson M. C., Shilkin K. B., Williams R. Nodular regenerative hyperplasia of the liver in Felty's syndrome. Q J Med. 1974 Jan;43(169):25–32. [PubMed] [Google Scholar]
  3. Cattan D., Vesin P., Wautier J., Kalifat R., Meignan S. Letter: Liver tumours and steroid hormones. Lancet. 1974 May 4;1(7862):878–878. doi: 10.1016/s0140-6736(74)90542-x. [DOI] [PubMed] [Google Scholar]
  4. Dosik H., Hsu L. Y., Todaro G. J., Lee S. L., Hirschhorn K., Selirio E. S., Alter A. A. Leukemia in Fanconi's anemia: cytogenetic and tumor virus susceptibility studies. Blood. 1970 Sep;36(3):341–352. [PubMed] [Google Scholar]
  5. Farber E. Pathogenesis of liver cancer. Arch Pathol. 1974 Sep;98(3):145–148. [PubMed] [Google Scholar]
  6. Farrell G. C., Joshua D. E., Uren R. F., Baird P. J., Perkins K. W., Kronenberg H. Androgen-induced hepatoma. Lancet. 1975 Feb 22;1(7904):430–432. doi: 10.1016/s0140-6736(75)91494-4. [DOI] [PubMed] [Google Scholar]
  7. Guy J. T., Auslander M. O. Androgenic steroids and hepatocellular carcinoma. Lancet. 1973 Jan 20;1(7795):148–148. doi: 10.1016/s0140-6736(73)90212-2. [DOI] [PubMed] [Google Scholar]
  8. Henderson J. T., Richmond J., Sumerling M. D. Androgenic-anabolic steroid therapy and hepatocellular carcinoma. Lancet. 1973 Apr 28;1(7809):934–934. doi: 10.1016/s0140-6736(73)91384-6. [DOI] [PubMed] [Google Scholar]
  9. Johnson F. L., Lerner K. G., Siegel M., Feagler J. R., Majerus P. W., Hartmann J. R., Thomas E. D. Association of androgenic-anabolic steroid therapy with development of hepatocellular carcinoma. Lancet. 1972 Dec 16;2(7790):1273–1276. doi: 10.1016/s0140-6736(72)92649-9. [DOI] [PubMed] [Google Scholar]
  10. Mays E. T., Christopherson W. M., Barrows G. H. Focal nodular hyperplasia of the liver. Possible relationship to oral contraceptives. Am J Clin Pathol. 1974 Jun;61(6):735–746. doi: 10.1093/ajcp/61.6.735. [DOI] [PubMed] [Google Scholar]
  11. Meadows A. T., Naiman J. L., Valdes-Dapena M. Hepatoma associated with androgen therapy for aplastic anemia. J Pediatr. 1974 Jan;84(1):109–110. doi: 10.1016/s0022-3476(74)80565-2. [DOI] [PubMed] [Google Scholar]
  12. RANSTROM S. Miliary hepatocellular adenomatosis. Acta Pathol Microbiol Scand. 1953;33(3):225–229. [PubMed] [Google Scholar]
  13. SOKAL J. E., FIRAT D. FANCONI'S ANEMIA AND HEPATIC CIRRHOSIS. Am J Med. 1965 Sep;39:464–475. [PubMed] [Google Scholar]
  14. Stauffer J. Q., Lapinski M. W., Honold D. J., Myers J. K. Focal nodular hyperplasia of the liver and intrahepatic hemorrhage in young women on oral contraceptives. Ann Intern Med. 1975 Sep;83(3):301–306. doi: 10.7326/0003-4819-83-3-301. [DOI] [PubMed] [Google Scholar]
  15. Sweeney E. C. Non-cirrhotic portal hypertension in Felty's syndrome. Ir J Med Sci. 1975 Apr;144(4):172–174. [PubMed] [Google Scholar]
  16. Swift M. Fanconi's anaemia in the genetics of neoplasia. Nature. 1971 Apr 9;230(5293):370–373. doi: 10.1038/230370a0. [DOI] [PubMed] [Google Scholar]
  17. Swift M., Zimmerman D., McDonough E. R. Squamous cell carcinomas in Fanconi's anemia. JAMA. 1971 Apr 12;216(2):325–326. [PubMed] [Google Scholar]
  18. Ziegenfuss J., Carabasi R. Androgens and hepatocellular carcinoma. Lancet. 1973 Feb 3;1(7797):262–262. doi: 10.1016/s0140-6736(73)90098-6. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES