Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1976 Sep;29(9):765–769. doi: 10.1136/jcp.29.9.765

Immune potential in human uraemia. 1. Relationship of glomerular filtration rate to depression of immune potential.

P R Byron, N P Mallick, G Taylor
PMCID: PMC476175  PMID: 789407

Abstract

Aspects of immune potential in uraemic subjects, categorized by glomerular filtration rate, were intercompared and compared with results obtained from a group of normal volunteers. Evidence is presented to show that depression of both cellular and humoral immune potential occurs with progressive reduction of glomerular filtration rate. Lymphocyte transformation testing to the non-specific mitogen PHA revealed a significant elevation of blastogenic response in uraemia after 96 hours of incubation.

Full text

PDF
765

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALCH H. H. The effect of severe battle injury and of post-traumatic renal failure on resistance to infection. Ann Surg. 1955 Aug;142(2):145–163. doi: 10.1097/00000658-195508000-00001. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Boulton-Jones J. M., Vick R., Cameron J. S., Black P. J. Immune responses in uremia. Clin Nephrol. 1973 Nov-Dec;1(6):351–360. [PubMed] [Google Scholar]
  3. Coulson A. S., Chalmers D. G. Response of human blood lymphocytes to tuberculin PPD in tissue culture. Immunology. 1967 Apr;12(4):417–429. [PMC free article] [PubMed] [Google Scholar]
  4. DAMMIN G. J., COUCH N. P., MURRAY J. E. Prolonged survival of skin homografts in uremic patients. Ann N Y Acad Sci. 1957 Mar 22;64(5):967–976. doi: 10.1111/j.1749-6632.1957.tb52488.x. [DOI] [PubMed] [Google Scholar]
  5. Daniels J. C., Sakai H., Fish J. C., Lindley J. D., Remmers A. R., Jr, Sarles H. E., Tyson K. R., Ritzmann S. E. The conversion phenomenon of uremic lymphocytes: mechanisms of nucleic acid kinetics. J Reticuloendothel Soc. 1971 May;9(5):409–423. [PubMed] [Google Scholar]
  6. Daniels J. C., Sakai H., Remmers A. R., Jr, Sarles H. E., Fish J. C., Cobb E. K., Levin W. C., Ritzmann S. E. In vitro reactivity of human lymphocytes in chronic uraemia: analysis and interpretation. Clin Exp Immunol. 1971 Feb;8(2):213–227. [PMC free article] [PubMed] [Google Scholar]
  7. FULTHORPE A. J. Tetanus antitoxin titration by haemagglutination. J Hyg (Lond) 1957 Sep;55(3):382–401. doi: 10.1017/s0022172400037293. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Huber H., Pastner D., Dittrich P., Braunsteiner H. In vitro reactivity of human lymphocytes in uraemia--a comparison with the impairment of delayed hypersensitivity. Clin Exp Immunol. 1969 Jul;5(1):75–82. [PMC free article] [PubMed] [Google Scholar]
  9. Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
  10. Merrill J. P. The immunologic capability of uremic patients. Cancer Res. 1968 Jul;28(7):1449–1451. [PubMed] [Google Scholar]
  11. STOLOFF I. L., STOUT R., MYERSON R. M., HAVENS W. P., Jr Production of antbody in patients with uremia. N Engl J Med. 1958 Aug 14;259(7):320–323. doi: 10.1056/NEJM195808142590703. [DOI] [PubMed] [Google Scholar]
  12. Sakai H., Daniels J. C., Lindley J. D., Remmers A. R., Jr, Sarles H. E., Ritzmann S. E. Accelerated nucleic-acid synthesis in uraemic lymphocytes. Lancet. 1970 Sep 5;2(7671):529–529. doi: 10.1016/s0140-6736(70)90156-x. [DOI] [PubMed] [Google Scholar]
  13. Soothill J. F., Steward M. W. The immunopathological significance of the heterogeneity of antibody affinity. Clin Exp Immunol. 1971 Aug;9(2):193–199. [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES