Abstract
Factor VII levels have been measured in 100 patients with liver disease following parenteral vitamin K1 therapy. There was good agreement between specific factor VII measurements and the one-stage prothrombin time apart from six patients with compensated cirrhosis in whom the prothrombin time was prolonged despite the presence of normal factor VII levels. A mean activity of 58% was found in patients with cirrhosis. Cirrhotic patients with features of hepatic decompensation had a significantly lower mean level of activity (40%) than the "contrast" patients with surgical obstruction of the major bile ducts (93%). Patients with chronic active liver disease had moderate depression of factor VII levels and those with non-cirrhotic liver damage had mean activities similar to the contrast group. Factor VII levels could not be correlated with BSP retention but there was a correlation with serum albumin concentration. It is concluded that the prothrombin time using Quick test with a standardized thromboplastin showing good sensitivity to factor VII, eg, the Manchester reagent (BCT), provides a reliable index of coagulability in chronic liver disease, and specific factor VII assays are not indicated.
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Selected References
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- Donaldson G. W., Davies S. H., Darg A., Richmond J. Coagulation factors in chronic liver disease. J Clin Pathol. 1969 Mar;22(2):199–204. doi: 10.1136/jcp.22.2.199. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Dymock I. W., Tucker J. S., Woolf I. L., Poller L., Thomson J. M. Coagulation studies as a prognostic index in acute liver failure. Br J Haematol. 1975 Mar;29(3):385–395. doi: 10.1111/j.1365-2141.1975.tb01836.x. [DOI] [PubMed] [Google Scholar]
- HALLEN A., NILSSON I. M. COAGULATION STUDIES IN LIVER DISEASE. Thromb Diath Haemorrh. 1964 Apr 15;11:51–63. [PubMed] [Google Scholar]
- Henning H., Yano M. Significance and practicability of Normotest in diagnosis of chronic liver diseases. Scand J Gastroenterol Suppl. 1973;19:119–123. [PubMed] [Google Scholar]
- Hillenbrand P., Sherlock S. Use of Normotest and Thrombotest, coagulation tests in hepatocellular disease. Scand J Gastroenterol Suppl. 1973;19:125–131. [PubMed] [Google Scholar]
- LOELIGER E. A., VAN DER ESCH B., MATTERN M. J., HEMKER H. C. THE BIOLOGICAL DISAPPEARANCE RATE OF PROTHROMBIN, FACTORS VII, IX AND X FROM PLASMA IN HYPOTHYROIDISM, HYPERTHYROIDISM, AND DURING FEVER. Thromb Diath Haemorrh. 1964 Jan 1;10:267–277. [PubMed] [Google Scholar]
- Poller L., Thomson J. M., Sear C. H., Thomas W. Identification of a congenital defect of factor VII in a colony of beagle dogs: the clinical use of the plasma. J Clin Pathol. 1971 Oct;24(7):626–632. doi: 10.1136/jcp.24.7.626. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Roberts H. R., Cederbaum A. I. The liver and blood coagulation: physiology and pathology. Gastroenterology. 1972 Aug;63(2):297–320. [PubMed] [Google Scholar]
- Zucker S., Cathey M. H., Sox P. J., Hall E. C. Standardization of laboratory tests for controlling anticoagulent therapy. Am J Clin Pathol. 1970 Mar;53(3):348–354. doi: 10.1093/ajcp/53.3.348. [DOI] [PubMed] [Google Scholar]