Abstract
Probabilistic maps of white matter pathways related to motor, somatosensory, auditory, visual, and limbic functions, and major white matter tracts (the corpus callosum, the inferior fronto-occipital fasciculus, and the middle cerebellar peduncle) were applied to evaluate the developmental trajectories of these tracts, using longitudinal diffusion tensor imaging (DTI) obtained in term-born and preterm-born healthy infants. Nineteen term-born and 30 preterm-born infants completed MR scans at three time points: Time-point 1, 41.6±2.7 postmenstrual weeks; Time-point 2, 46.0±2.9 postmenstrual weeks; and Time-point 3, 50.8±3.7 postmenstrual weeks. The DTI-derived scalar values (fractional anisotropy, eigenvalues, and radial diffusivity) of the three time points are available in this Data article.
Keywords: Term, Preterm, Infant, Diffusion tensor imaging, Atlas
Specifications Table
| Subject area | Biology |
| More specific subject area | Developmental Medicine, Neonatology |
| Type of data | Table |
| How data was acquired | MRI: 3.0 Tesla Siemens TIM Trio scanner (Siemens Medical Solutions, Erlangen, Germany) |
| Data format | Analyze |
| Experimental factors | The diffusion tensor was calculated using DtiStudio. Each image was transformed to the JHU-neonate atlas using dual-channel large deformation diffeomorphic metric mapping. |
| Experimental features | DTIs of 19 term-born and 30 preterm-born healthy infants were acquired at three time points. |
| Data source location | Queen’s Medical Center, University of Hawaii, Honolulu, Hawaii, USA |
| Data accessibility | Data is within this article. |
Value of the data
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The data demonstrated in this paper can be used as a reference for future research related to early brain development.
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The dataset from healthy term-born infants can be used as a control for future disease-oriented studies.
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The data can be used a benchmark to evaluate other image analysis methods.
1. Data
The fractional anisotropy (FA) (Table 1), the first eigenvalue (e0) (Table 2), the second eigenvalue (e1) (Table 3), the third eigenvalue (e2) (Table 4), and the radial diffusivity (Table 5) of each white matter pathway [1] at each time point demonstrated the differences between term- and preterm-born groups. Results were sorted by the group effect from lower to higher p-values. Note: the group effect was not calculated when the effect of group*timepoint was significant (p<0.05). AR=acoustic radiation, BCC=body of the corpus callosum, CG=cingulum, CST=corticospinal tract, GCC=genu of the corpus callosum, IFO=inferior fronto-occipital fasciculus, ILF=the inferior longitudinal fasciculus, Lt.=left, MCP=middle cerebellar peduncle, OR=optic radiation, PMC=primary motor cortex, PSC=primary somatosensory cortex, Rt.=right, SCC=splenium of the corpus callosum, Thal=thalamus, UNC=the uncinate fasciculus, V1-V4=the pathway that connects the V1/V2 and the V4, and V1-MT=the pathway that connects the V1/V2 and the V5/MT+.
Table 1.
Corrected fractional anisotropy (FA) values of each time point and the difference between term- and preterm-born groups. Results are sorted by the group effect from lower to higher p-value.
| Corrected FA; mean (range) |
Group effect (p) | ||||
|---|---|---|---|---|---|
| Time point 1 | Time point 2 | Time point 3 | |||
| GCC | term | 0.255(0.224–0.293) | 0.284(0.263–0.319) | 0.293(0.254–0.335) | 0.138 |
| preterm | 0.236(0.170–0.284) | 0.262(0.174–0.298) | 0.289(0.236–0.337) | ||
| Rt.Thal-PSC | term | 0.252(0.222–0.301) | 0.278(0.245–0.311) | 0.292(0.260–0.342) | 0.170 |
| preterm | 0.255(0.232–0.281) | 0.279(0.253–0.314) | 0.302(0.264–0.341) | ||
| Lt.V1-V4 | term | 0.093(0.075–0.112) | 0.102(0.074–0.124) | 0.111(0.077–0.137) | 0.486 |
| preterm | 0.099(0.085–0.122) | 0.110(0.090–0.144) | 0.120(0.087–0.153) | ||
| Rt.ILF | term | 0.199(0.171–0.229) | 0.230(0.184–0.268) | 0.241(0.209–0.272) | 1.000 |
| preterm | 0.188(0.151–0.229) | 0.212(0.166–0.265) | 0.241(0.198–0.286) | ||
| Rt.AR | term | 0.258(0.235–0.284) | 0.280(0.262–0.297) | 0.291(0.249–0.332) | 1.000 |
| preterm | 0.250(0.220–0.279) | 0.273(0.248–0.300) | 0.289(0.262–0.328) | ||
| Rt.UNC | term | 0.209(0.192–0.227) | 0.238(0.210–0.261) | 0.248(0.218–0.287) | 1.000 |
| preterm | 0.204(0.160–0.246) | 0.227(0.174–0.260) | 0.249(0.195–0.274) | ||
| Rt.IFO | term | 0.219(0.195–0.258) | 0.237(0.208–0.270) | 0.246(0.217–0.285) | 1.000 |
| preterm | 0.211(0.175–0.258) | 0.231(0.199–0.266) | 0.245(0.213–0.281) | ||
| Lt.UNC | term | 0.208(0.182–0.237) | 0.233(0.206–0.275) | 0.247(0.221–0.270) | 1.000 |
| preterm | 0.198(0.164–0.237) | 0.225(0.189–0.268) | 0.250(0.212–0.284) | ||
| BCC | term | 0.254(0.196–0.312) | 0.271(0.228–0.321) | 0.284(0.231–0.344) | 1.000 |
| preterm | 0.243(0.195–0.290) | 0.261(0.214–0.328) | 0.281(0.212–0.361) | ||
| Lt.Thal-PSC | term | 0.230(0.215–0.264) | 0.255(0.225–0.280) | 0.271(0.239–0.307) | 1.000 |
| preterm | 0.235(0.211–0.259) | 0.253(0.234–0.289) | 0.279(0.251–0.319) | ||
| Lt.ILF | term | 0.210(0.179–0.230) | 0.247(0.213–0.267) | 0.251(0.202–0.282) | 1.000 |
| preterm | 0.197(0.152–0.231) | 0.229(0.181–0.278) | 0.248(0.198–0.299) | ||
| Rt.CST | term | 0.358(0.306–0.399) | 0.385(0.329–0.477) | 0.410(0.350–0.472) | 1.000 |
| preterm | 0.351(0.286–0.401) | 0.387(0.316–0.442) | 0.423(0.327–0.475) | ||
| MCP | term | 0.259(0.220–0.306) | 0.297(0.249–0.358) | 0.322(0.270–0.365) | 1.000 |
| preterm | 0.260(0.198–0.302) | 0.297(0.263–0.335) | 0.332(0.295–0.399) | ||
| Rt.Premotor-PMC | term | 0.147(0.120–0.167) | 0.165(0.137–0.186) | 0.174(0.139–0.212) | 1.000 |
| preterm | 0.145(0.122–0.182) | 0.164(0.144–0.195) | 0.181(0.145–0.216) | ||
| Rt.V1-V4 | term | 0.113(0.086–0.130) | 0.128(0.099–0.155) | 0.136(0.101–0.170) | 1.000 |
| preterm | 0.113(0.088–0.135) | 0.128(0.099–0.157) | 0.138(0.098–0.167) | ||
| Lt.OR | term | 0.302(0.276–0.375) | 0.327(0.275–0.371) | 0.349(0.315–0.385) | 1.000 |
| preterm | 0.299(0.254–0.348) | 0.322(0.286–0.373) | 0.350(0.303–0.420) | ||
| Lt.IFO | term | 0.239(0.220–0.302) | 0.256(0.211–0.294) | 0.259(0.228–0.295) | 1.000 |
| preterm | 0.235(0.190–0.282) | 0.251(0.203–0.285) | 0.263(0.230–0.320) | ||
| Rt.CG | term | 0.159(0.131–0.213) | 0.163(0.134–0.210) | 0.181(0.150–0.206) | 1.000 |
| preterm | 0.158(0.090–0.208) | 0.163(0.110–0.223) | 0.184(0.139–0.229) | ||
| Rt.V1 -MT | term | 0.134(0.109–0.168) | 0.160(0.131–0.193) | 0.169(0.124–0.267) | 1.000 |
| preterm | 0.139(0.116–0.170) | 0.155(0.122–0.228) | 0.167(0.117–0.227) | ||
| Rt.OR | term | 0.270(0.241–0.315) | 0.299(0.269–0.321) | 0.306(0.261–0.335) | 1.000 |
| preterm | 0.266(0.222–0.320) | 0.293(0.237–0.352) | 0.315(0.256–0.369) | ||
| Lt.CG | term | 0.172(0.121–0.209) | 0.183(0.155–0.222) | 0.193(0.147–0.247) | 1.000 |
| preterm | 0.171(0.116–0.224) | 0.179(0.121–0.217) | 0.197(0.144–0.266) | ||
| Lt.Premotor-PMC | term | 0.141(0.125–0.157) | 0.160(0.144–0.184) | 0.170(0.142–0.209) | 1.000 |
| preterm | 0.141(0.117–0.170) | 0.158(0.138–0.190) | 0.173(0.146–0.204) | ||
| Lt.V1-MT | term | 0.112(0.089–0.136) | 0.128(0.104–0.162) | 0.141(0.121–0.178) | 1.000 |
| preterm | 0.113(0.093–0.139) | 0.127(0.111–0.160) | 0.141(0.112–0.191) | ||
| Lt.AR | term | 0.244(0.221–0.269) | 0.270(0.252–0.296) | 0.280(0.247–0.306) | – |
| preterm | 0.240(0.214–0.269) | 0.257(0.231–0.286) | 0.277(0.250–0.314) | ||
| SCC | term | 0.314(0.274–0.357) | 0.343(0.305–0.391) | 0.369(0.310–0.428) | – |
| preterm | 0.303(0.255–0.355) | 0.332(0.283–0.396) | 0.374(0.288–0.481) | ||
| Lt.CST | term | 0.357(0.320–0.386) | 0.386(0.352–0.455) | 0.408(0.354–0.451) | – |
| preterm | 0.351(0.303–0.431) | 0.384(0.322–0.434) | 0.428(0.346–0.472) | ||
Table 2.
Corrected first eigenvalues (e0) of each time point and the difference between term- and preterm-born groups. Results are sorted by the group effect from lower to higher p-value.
| Corrected e0; mean (range) |
Group effect (p) | ||||
|---|---|---|---|---|---|
| Time point 1 | Time point 2 | Time point 3 | |||
| BCC | term | 0.00182(0.00169–0.00201) | 0.00181(0.00166–0.00200) | 0.00178(0.00165–0.00196) | 0.002 |
| preterm | 0.00193(0.00176–0.00217) | 0.00191(0.00175–0.00213) | 0.00187(0.00163–0.00207) | ||
| Lt.V1-V4 | term | 0.00135(0.00123–0.00143) | 0.00126(0.00117–0.00139) | 0.00119(0.00108–0.00130) | 0.033 |
| preterm | 0.00142(0.00128–0.00160) | 0.00132(0.00114–0.00149) | 0.00123(0.00112–0.00137) | ||
| Rt.Thal-PSC | term | 0.00143(0.00138–0.00149) | 0.00137(0.00130–0.00143) | 0.00132(0.00127–0.00137) | 0.046 |
| preterm | 0.00147(0.00140–0.00159) | 0.00140(0.00131–0.00152) | 0.00135(0.00125–0.00144) | ||
| Lt.V1-MT | term | 0.00146(0.00138–0.00155) | 0.00139(0.00128–0.00149) | 0.00130(0.00120–0.00145) | 0.051 |
| preterm | 0.00154(0.00142–0.00175) | 0.00144(0.00133–0.00158) | 0.00134(0.00124–0.00157) | ||
| Lt.ILF | term | 0.00166(0.00159–0.00170) | 0.00158(0.00145–0.00166) | 0.00149(0.00139–0.00157) | 0.102 |
| preterm | 0.00170(0.00151–0.00185) | 0.00162(0.00144–0.00179) | 0.00154(0.00142–0.00176) | ||
| Lt.Premotor-PMC | term | 0.00131(0.00124–0.00135) | 0.00125(0.00121–0.00134) | 0.00120(0.00115–0.00128) | 0.423 |
| preterm | 0.00135(0.00125–0.00147) | 0.00127(0.00119–0.00141) | 0.00122(0.00113–0.00132) | ||
| Rt.Premotor-PMC | term | 0.00133(0.00125–0.00139) | 0.00126(0.00121–0.00134) | 0.00121(0.00116–0.00127) | 0.641 |
| preterm | 0.00136(0.00129–0.00149) | 0.00128(0.00119–0.00143) | 0.00123(0.00115–0.00132) | ||
| SCC | term | 0.00185(0.00176–0.00193) | 0.00181(0.00168–0.00187) | 0.00175(0.00167–0.00189) | 0.646 |
| preterm | 0.00189(0.00169–0.00207) | 0.00184(0.00169–0.00196) | 0.00180(0.00160–0.00204) | ||
| Lt.Thal-PSC | term | 0.00143(0.00139–0.00149) | 0.00136(0.00130–0.00143) | 0.00131(0.00122–0.00135) | 0.765 |
| preterm | 0.00145(0.00137–0.00160) | 0.00138(0.00130–0.00147) | 0.00133(0.00121–0.00142) | ||
| GCC | term | 0.00184(0.00176–0.00194) | 0.00176(0.00166–0.00186) | 0.00169(0.00160–0.00180) | 0.848 |
| preterm | 0.00186(0.00173–0.00198) | 0.00180(0.00165–0.00195) | 0.00172(0.00155–0.00185) | ||
| Lt.OR | term | 0.00161(0.00151–0.00168) | 0.00151(0.00140–0.00158) | 0.00145(0.00133–0.00155) | 0.849 |
| preterm | 0.00164(0.00152–0.00179) | 0.00154(0.00139–0.00172) | 0.00149(0.00136–0.00166) | ||
| Rt.ILF | term | 0.00163(0.00154–0.00172) | 0.00153(0.00138–0.00163) | 0.00144(0.00132–0.00153) | 0.929 |
| preterm | 0.00165(0.00151–0.00178) | 0.00156(0.00143–0.00170) | 0.00148(0.00135–0.00158) | ||
| Rt.CST | term | 0.00167(0.00158–0.00174) | 0.00163(0.00152–0.00176) | 0.00159(0.00146–0.00172) | 1.000 |
| preterm | 0.00168(0.00158–0.00187) | 0.00165(0.00155–0.00183) | 0.00164(0.00153–0.00175) | ||
| Lt.CG | term | 0.00144(0.00130–0.00153) | 0.00135(0.00126–0.00151) | 0.00126(0.00120–0.00139) | 1.000 |
| preterm | 0.00147(0.00128–0.00159) | 0.00138(0.00124–0.00150) | 0.00129(0.00117–0.00138) | ||
| Rt.V1-V4 | term | 0.00140(0.00125–0.00154) | 0.00132(0.00123–0.00142) | 0.00124(0.00114–0.00136) | 1.000 |
| preterm | 0.00145(0.00129–0.00160) | 0.00135(0.00120–0.00152) | 0.00127(0.00115–0.00143) | ||
| Rt.IFO | term | 0.00148(0.00140–0.00156) | 0.00140(0.00132–0.00147) | 0.00134(0.00126–0.00143) | 1.000 |
| preterm | 0.00150(0.00143–0.00167) | 0.00141(0.00133–0.00151) | 0.00135(0.00128–0.00143) | ||
| MCP | term | 0.00158(0.00149–0.00166) | 0.00152(0.00141–0.00162) | 0.00148(0.00138–0.00176) | 1.000 |
| preterm | 0.00160(0.00149–0.00174) | 0.00155(0.00141–0.00169) | 0.00150(0.00134–0.00164) | ||
| Lt.AR | term | 0.00138(0.00132–0.00146) | 0.00132(0.00127–0.00137) | 0.00128(0.00123–0.00133) | 1.000 |
| preterm | 0.00139(0.00131–0.00151) | 0.00133(0.00126–0.00142) | 0.00129(0.00121–0.00136) | ||
| Rt.UNC | term | 0.00147(0.00141–0.00152) | 0.00142(0.00136–0.00148) | 0.00136(0.00128–0.00143) | 1.000 |
| preterm | 0.00148(0.00138–0.00155) | 0.00142(0.00131–0.00152) | 0.00137(0.00131–0.00143) | ||
| Rt.CG | term | 0.00143(0.00132–0.00154) | 0.00133(0.00125–0.00142) | 0.00125(0.00117–0.00135) | 1.000 |
| preterm | 0.00144(0.00132–0.00162) | 0.00135(0.00128–0.00153) | 0.00126(0.00118–.00134) | ||
| Lt.UNC | term | 0.00146(0.00136–0.00153) | 0.00140(0.00133–0.00146) | 0.00135(0.00127–0.00140) | 1.000 |
| preterm | 0.00147(0.00141–0.00154) | 0.00141(0.00133–0.00151) | 0.00136(0.00129–0.00143) | ||
| Rt.V1-MT | term | 0.00149(0.00138–0.00156) | 0.00141(0.00133–0.00150) | 0.00133(0.00122–0.00162) | 1.000 |
| preterm | 0.00153(0.00137–0.00170) | 0.00142(0.00129–0.00169) | 0.00133(0.00124–0.00160) | ||
| Lt.IFO | term | 0.00147(0.00137–0.00157) | 0.00140(0.00132–0.00147) | 0.00133(0.00126–0.00142) | 1.000 |
| preterm | 0.00148(0.00139–0.00163) | 0.00139(0.00129–0.00152) | 0.00134(0.00128–0.00144) | ||
| Rt.OR | term | 0.00164(0.00153–0.00173) | 0.00152(0.00139–0.00161) | 0.00144(0.00135–0.00155) | - |
| preterm | 0.00165(0.00145–0.00181) | 0.00156(0.00137–0.00170) | 0.00148(0.00133–0.00169) | ||
| Lt.CST | term | 0.00151(0.00143–.00158) | 0.00149(0.00143–0.00156) | 0.00145(0.00139–0.00153) | - |
| preterm | 0.00151(0.00142–0.00160) | 0.00149(0.00143–0.00155) | 0.00149(0.00136–0.00164) | ||
| Rt.AR | term | 0.00140(0.00134–0.00146) | 0.00135(0.00128–0.00141) | 0.00130(0.00124–0.00136) | - |
| preterm | 0.00140(0.00133–0.00148) | 0.00136(0.00129–0.00144) | 0.00132(0.00121–0.00140) | ||
Table 3.
Corrected second eigenvalues (e1) of each time point and the difference between term- and preterm-born groups. Results are sorted by the group effect from lower to higher p-value.
| Corrected e1; mean (range) |
Group effect (p) | ||||
|---|---|---|---|---|---|
| Time point 1 | Time point 2 | Time point 3 | |||
| Lt.V1-MT | term | 0.00130(0.00121–0.00143) | 0.00121(0.00113–0.00131) | 0.00111(0.00100–0.00122) | 0.018 |
| preterm | 0.00137(0.00125–0.00153) | 0.00125(0.00116–0.00136) | 0.00115(0.00108–0.00124) | ||
| Lt.ILF | term | 0.00128(0.00122–0.00134) | 0.00117(0.00107–0.00124) | 0.00110(0.00103–0.00118) | 0.029 |
| preterm | 0.00134(0.00119–0.00150) | 0.00123(0.00112–0.00137) | 0.00114(0.00104–0.00132) | ||
| BCC | term | 0.00136(0.00117–0.00152) | 0.00131(0.00114–0.00147) | 0.00126(0.00112–0.00152) | 0.061 |
| preterm | 0.00147(0.00127–0.00169) | 0.00140(0.00116–0.00159) | 0.00133(0.00105–0.00178) | ||
| Rt.ILF | term | 0.00128(0.00119–0.00133) | 0.00116(0.00109–0.00120) | 0.00108(0.00103–0.00113) | 0.069 |
| preterm | 0.00132(0.00118–0.00149) | 0.00122(0.00108–0.00138) | 0.00111(0.00103–0.00120) | ||
| GCC | term | 0.00129(0.00121–0.00140) | 0.00120(0.00108–0.00128) | 0.00114(0.00100–0.00127) | 0.098 |
| preterm | 0.00135(0.00119–0.00155) | 0.00126(0.00107–0.00146) | 0.00117(0.00102–0.00133) | ||
| Lt.V1-V4 | term | 0.00122(0.00113–0.00131) | 0.00113(0.00106–0.00124) | 0.00105(0.00099–0.00114) | 0.235 |
| preterm | 0.00129(0.00115–0.00147) | 0.00118(0.00103–0.00132) | 0.00108(0.00099–0.00120) | ||
| SCC | term | 0.00120(0.00111–0.00127) | 0.00111(0.00101–0.00120) | 0.00102(0.00091–0.00117) | 0.350 |
| preterm | 0.00125(0.00113–0.00140) | 0.00115(0.00102–0.00128) | 0.00104(0.00090–0.00127) | ||
| Lt.Premotor-PMC | term | 0.00115(0.00111–0.00120) | 0.00107(0.00102–0.00112) | 0.00102(0.00096–0.00110) | 0.407 |
| preterm | 0.00119(0.00108–0.00131) | 0.00110(0.00102–0.00119) | 0.00104(0.00095–0.00110) | ||
| Rt.Premotor-PMC | term | 0.00116(0.00109–0.00121) | 0.00106(0.00101–0.00112) | 0.00101(0.00094–0.00106) | 0.627 |
| preterm | 0.00119(0.00111–0.00132) | 0.00109(0.00101–0.00118) | 0.00102(0.00096–0.00111) | ||
| Rt.Thal-PSC | term | 0.00104(0.00097–0.00108) | 0.00095(0.00089–0.00100) | 0.00090(0.00083–0.00095) | 0.754 |
| preterm | 0.00106(0.00098–0.00116) | 0.00098(0.00091–0.00105) | 0.00091(0.00086–0.00099) | ||
| Lt.UNC | term | 0.00113(0.00109–0.00116) | 0.00106(0.00102–0.00109) | 0.00100(0.00097–0.00103) | 1.000 |
| preterm | 0.00115(0.00108–0.00127) | 0.00107(0.00101–0.00115) | 0.00101(0.00095–0.00105) | ||
| Rt.UNC | term | 0.00114(0.00110–0.00119) | 0.00106(0.00101–0.00110) | 0.00101(0.00095–0.00105) | 1.000 |
| preterm | 0.00115(0.00103–0.00125) | 0.00108(0.00103–0.00116) | 0.00102(0.00097–0.00106) | ||
| Rt.IFO | term | 0.00117(0.00110–0.00125) | 0.00109(0.00104–0.00113) | 0.00103(0.00098–0.00107) | 1.000 |
| preterm | 0.00119(0.00112–0.00137) | 0.00110(0.00105–0.00122) | 0.00104(0.00098–0.00110) | ||
| Rt.V1-V4 | term | 0.00124(0.00111–0.00135) | 0.00114(0.00108–0.00122) | 0.00106(0.00099-0.00115) | 1.000 |
| preterm | 0.00128(0.00114–0.00143) | 0.00117(0.00104–0.00134) | 0.00109(0.00099–0.00124) | ||
| Lt.CG | term | 0.00123(0.00117–0.00130) | 0.00116(0.00109–0.00122) | 0.00106(0.00100–0.00113) | 1.000 |
| preterm | 0.00125(0.00117–0.00133) | 0.00117(0.00110–0.00128) | 0.00108(0.00099–0.00114) | ||
| Lt.AR | term | 0.00107(0.00103–0.00113) | 0.00100(0.00093–0.00105) | 0.00096(0.00091–0.00103) | 1.000 |
| preterm | 0.00108(0.00101–0.00115) | 0.00102(0.00097–0.00108) | 0.00097(0.00091–0.00103) | ||
| Lt.OR | term | 0.00115(0.00100–0.00122) | 0.00105(0.00094–0.00114) | 0.00099(0.00089–0.00108) | 1.000 |
| preterm | 0.00117(0.00106–0.00131) | 0.00108(0.00096–0.00124) | 0.00101(0.00091–0.00112) | ||
| Lt.Thal-PSC | term | 0.00109(0.00103–0.00113) | 0.00101(0.00094–0.00106) | 0.00095(0.00091–0.00099) | 1.000 |
| preterm | 0.00110(0.00103–0.00121) | 0.00102(0.00096–0.00111) | 0.00095(0.00090–0.00100) | ||
| Rt.V1-MT | term | 0.00129(0.00121–0.00138) | 0.00119(0.00110–0.00128) | 0.00110(0.00101–0.00120) | 1.000 |
| preterm | 0.00132(0.00121–0.00143) | 0.00120(0.00106–0.00132) | 0.00111(0.00098–0.00127) | ||
| Rt.CST | term | 0.00100(0.00093–0.00108) | 0.00093(0.00088–0.00100) | 0.00089(0.00081–0.00103) | 1.000 |
| preterm | 0.00102(0.00094–0.00117) | 0.00094(0.00081–0.00107) | 0.00089(0.00078–0.00113) | ||
| Rt.AR | term | 0.00104(0.00099–0.00113) | 0.00099(0.00093–0.00110) | 0.00095(0.00089–0.00102) | 1.000 |
| preterm | 0.00105(0.00097–0.00116) | 0.00100(0.00091–0.00106) | 0.00096(0.00090–0.00101) | ||
| Rt.CG | term | 0.00125(0.00120–0.00136) | 0.00118(0.00110–0.00125) | 0.00109(0.00102–0.00117) | 1.000 |
| preterm | 0.00126(0.00117–0.00133) | 0.00119(0.00113–0.00129) | 0.00110(0.00103–0.00115) | ||
| Lt.IFO | term | 0.00115(0.00109–0.00128) | 0.00106(0.00100–0.00114) | 0.00102(0.00095–0.00112) | 1.000 |
| preterm | 0.00116(0.00109–0.00135) | 0.00108(0.00104–0.00115) | 0.00102(0.00096–0.00106) | ||
| Lt.CST | term | 0.00091(0.00088–0.00097) | 0.00085(0.00080–0.00090) | 0.00080(0.00072–0.00089) | 1.000 |
| preterm | 0.00092(0.00086–0.00102) | 0.00086(0.00078–0.00100) | 0.00080(0.00072–0.00091) | ||
| Rt.OR | term | 0.00123(0.00111–0.00131) | 0.00112(0.00101–0.00120) | 0.00106(0.00099–0.00117) | 1.000 |
| preterm | 0.00123(0.00111–0.00137) | 0.00113(0.00098–0.00128) | 0.00106(0.00094–0.00121) | ||
| MCP | term | 0.00113(0.00105–0.00124) | 0.00104(0.00096–0.00113) | 0.00099(0.00086–0.00114) | - |
| preterm | 0.00115(0.00105–0.00125) | 0.00108(0.00098–0.00121) | 0.00099(0.00079–0.00112) | ||
Table 4.
Corrected third eigenvalues (e2) of each time point and the difference between term- and preterm-born groups. Results are sorted by the group effect from lower to higher p-value.
| Corrected e2; mean (range) |
Group effect (p) | ||||
|---|---|---|---|---|---|
| Time point 1 | Time point 2 | Time point 3 | |||
| Lt.ILF | term | 0.00110(0.00103–0.00118) | 0.00097(0.00091–0.00108) | 0.00091(0.00084–0.00098) | 0.007 |
| preterm | 0.00116(0.00105–0.00135) | 0.00104(0.00092–0.00120) | 0.00095(0.00087–0.00113) | ||
| BCC | term | 0.00110(0.00097–0.00124) | 0.00106(0.00091–0.00120) | 0.00102(0.00088–0.00121) | 0.028 |
| preterm | 0.00120(0.00098–0.00144) | 0.00114(0.00094–0.00134) | 0.00108(0.00087–0.00132) | ||
| GCC | term | 0.00114(0.00103–0.00125) | 0.00102(0.00093–0.00113) | 0.00095(0.00086–0.00104) | 0.038 |
| preterm | 0.00120(0.00104–0.00136) | 0.00110(0.00094–0.00129) | 0.00098(0.00087–0.00115) | ||
| Lt.V1-MT | term | 0.00118(0.00107–0.00129) | 0.00108(0.00099–0.00116) | 0.00099(0.00089–0.00109) | 0.082 |
| preterm | 0.00123(0.00111–0.00139) | 0.00112(0.00104–0.00126) | 0.00101(0.00095–0.00108) | ||
| Lt.AR | term | 0.00085(0.00079–0.00091) | 0.00077(0.00073–0.00081) | 0.00072(0.00069–0.00077) | 0.084 |
| preterm | 0.00087(0.00079–0.00096) | 0.00080(0.00076–0.00085) | 0.00074(0.00067–0.00079) | ||
| Rt.ILF | term | 0.00110(0.00102–0.00117) | 0.00097(0.00088–0.00103) | 0.00089(0.00083–0.00095) | 0.087 |
| preterm | 0.00114(0.00102–0.00134) | 0.00103(0.00093–0.00124) | 0.00092(0.00082–0.00099) | ||
| Lt.UNC | term | 0.00097(0.00093–0.00101) | 0.00089(0.00085–0.00093) | 0.00084(0.00080–0.00087) | 0.171 |
| preterm | 0.00100(0.00091–0.00111) | 0.00091(0.00086–0.00097) | 0.00084(0.00078–0.00087) | ||
| Rt.IFO | term | 0.00096(0.00090–0.00101) | 0.00087(0.00082–0.00092) | 0.00081(0.00076–0.00086) | 0.174 |
| preterm | 0.00099(0.00090–0.00116) | 0.00089(0.00082–0.00099) | 0.00082(0.00078–0.00086) | ||
| Rt.AR | term | 0.00084(0.00080–0.00089) | 0.00077(0.00071–0.00080) | 0.00073(0.00065–0.00079) | 0.256 |
| preterm | 0.00086(0.00078–0.00096) | 0.00079(0.00074–0.00087) | 0.00074(0.00070–0.00078) | ||
| SCC | term | 0.00104(0.00095–0.00111) | 0.00095(0.00088–0.00105) | 0.00087(0.00076–0.00098) | 0.326 |
| preterm | 0.00108(0.00094–0.00122) | 0.00099(0.00087–0.00109) | 0.00088(0.00075–0.00103) | ||
| Rt.UNC | term | 0.00098(0.00094–0.00102) | 0.00089(0.00084–0.00094) | 0.00083(0.00078–0.00088) | 0.328 |
| preterm | 0.00100(0.00088–0.00113) | 0.00092(0.00085–0.00099) | 0.00084(0.00080–0.00089) | ||
| Lt.CG | term | 0.00102(0.00097–0.00111) | 0.00093(0.00087–0.00099) | 0.00085(0.00078–0.00092) | 0.337 |
| preterm | 0.00104(0.00096–0.00110) | 0.00096(0.00087–0.00106) | 0.00087(0.00080–0.00092) | ||
| Lt.V1-V4 | term | 0.00112(0.00106–0.00112) | 0.00103(0.00096–0.00111) | 0.00095(0.00091–0.00105) | 0.445 |
| preterm | 0.00117(0.00106–0.00134) | 0.00106(0.00096–0.00122) | 0.00097(0.00089–0.00109) | ||
| Lt.Premotor-PMC | term | 0.00099(0.00091–0.00104) | 0.00090(0.00086–0.00095) | 0.00086(0.00079–0.00092) | 0.847 |
| preterm | 0.00102(0.00094–0.00116) | 0.00093(0.00084–0.00102) | 0.00087(0.00081–0.00094) | ||
| Rt.Thal-PSC | term | 0.00089(0.00080–0.00095) | 0.00081(0.00075–0.00087) | 0.00076(0.00070–0.00080) | 1.000 |
| preterm | 0.00091(0.00082–0.00102) | 0.00083(0.00075–0.00090) | 0.00076(0.00072–0.00081) | ||
| Rt.OR | term | 0.00096(0.00083–0.00105) | 0.00083(0.00075–0.00092) | 0.00077(0.00069–0.00085) | 1.000 |
| preterm | 0.00098(0.00081–0.00117) | 0.00088(0.00073–0.00103) | 0.00079(0.00070–0.00093) | ||
| Lt.OR | term | 0.00088(0.00076–0.00095) | 0.00078(0.00069–0.00091) | 0.00071(0.00065–0.00076) | 1.000 |
| preterm | 0.00090(0.00078–0.00111) | 0.00081(0.00069–0.00093) | 0.00072(0.00063–0.00082) | ||
| Rt.V1-V4 | term | 0.00112(0.00104–0.00123) | 0.00102(0.00096–0.00111) | 0.00095(0.00088–0.00105) | 1.000 |
| preterm | 0.00116(0.00101–0.00131) | 0.00105(0.00091–0.00117) | 0.00096(0.00086–0.00112) | ||
| Rt.Premotor-PMC | term | 0.00099(0.00091–0.00104) | 0.00091(0.00086–0.00096) | 0.00086(0.00079–0.00090) | 1.000 |
| preterm | 0.00102(0.00094–0.00117) | 0.00092(0.00084–0.00102) | 0.00086(0.00080–0.00097) | ||
| MCP | term | 0.00100(0.00092–0.00108) | 0.00090(0.00082–0.00098) | 0.00083(0.00074–0.00093) | 1.000 |
| preterm | 0.00101(0.00093–0.00109) | 0.00091(0.00082–0.00099) | 0.00083(0.00067–0.00091) | ||
| Lt.Thal-PSC | term | 0.00092(0.00085–0.00097) | 0.00083(0.00078–0.00088) | 0.00078(0.00073–0.00082) | 1.000 |
| preterm | 0.00093(0.00085–0.00104) | 0.00085(0.00079–0.00094) | 0.00078(0.00072–0.00083) | ||
| Rt.CG | term | 0.00104(0.00097–0.00112) | 0.00096(0.00087–0.00101) | 0.00087(0.00080–0.00093) | 1.000 |
| preterm | 0.00105(0.00096–0.00118) | 0.00098(0.00088–0.00108) | 0.00087(0.00076–0.00094) | ||
| Rt.V1-MT | term | 0.00114(0.00103–0.00123) | 0.00103(0.00094–0.00112) | 0.00095(0.00086–0.00107) | 1.000 |
| preterm | 0.00116(0.00103–0.00129) | 0.00104(0.00088–0.00118) | 0.00096(0.00085–0.00116) | ||
| Lt.IFO | term | 0.00090(0.00085–0.00099) | 0.00083(0.00078–0.00089) | 0.00079(0.00074–0.00084) | 1.000 |
| preterm | 0.00092(0.00082–0.00111) | 0.00083(0.00076–0.00088) | 0.00078(0.00072–0.00083) | ||
| Rt.CST | term | 0.00087(0.00082–0.00094) | 0.00081(0.00072–0.00090) | 0.00075(0.00062–0.00080) | 1.000 |
| preterm | 0.00088(0.00077–0.00101) | 0.00081(0.00073–0.00089) | 0.00075(0.00057–0.00089) | ||
| Lt.CST | term | 0.00077(0.00072–0.00081) | 0.00072(0.00064–0.00077) | 0.00067(0.00063–0.00073) | 1.000 |
| preterm | 0.00078(0.00069–0.00086) | 0.00072(0.00067–0.00080) | 0.00066(0.00061–0.00075) | ||
Table 5.
Corrected radial diffusivity values of each time point and the difference between term- and preterm-born groups. Results are sorted by the group effect from lower to higher p-value.
| Corrected radial diffusivity; mean (range) |
Group effect (p) | ||||
|---|---|---|---|---|---|
| Time point 1 | Time point 2 | Time point 3 | |||
| Lt.ILF | term | 0.00119(0.00114–0.00125) | 0.00107(0.00099–0.00116) | 0.00101(0.00095–0.00108) | 0.010 |
| preterm | 0.00125(0.00113–0.00143) | 0.00113(0.00102–0.00128) | 0.00105(0.00097–0.00123) | ||
| Lt.V1-MT | term | 0.00124(0.00116–0.00136) | 0.00115(0.00107–0.00124) | 0.00105(0.00095–0.00116) | 0.033 |
| preterm | 0.00130(0.00118–0.00146) | 0.00119(0.00110–0.00131) | 0.00108(0.00101–0.00116) | ||
| BCC | term | 0.00123(0.00109–0.00138) | 0.00119(0.00102–0.00134) | 0.00114(0.00100–0.00137) | 0.035 |
| preterm | 0.00133(0.00115–0.00156) | 0.00127(0.00105–0.00146) | 0.00121(0.00096–0.00155) | ||
| Rt.ILF | term | 0.00119(0.00113–0.00125) | 0.00107(0.00099–0.00111) | 0.00099(0.00093–0.00104) | 0.053 |
| preterm | 0.00123(0.00110–0.00142) | 0.00112(0.00100–0.00131) | 0.00102(0.00096–0.00109) | ||
| GCC | term | 0.00122(0.00112–0.00133) | 0.00111(0.00100–0.00121) | 0.00105(0.00093–0.00112) | 0.057 |
| preterm | 0.00128(0.00112–0.00146) | 0.00118(0.00100–0.00138) | 0.00108(0.00094–0.00124) | ||
| Lt.CG | term | 0.00113(0.00108–0.00121) | 0.00104(0.00098–0.00109) | 0.00096(0.00092–0.00101) | 0.192 |
| preterm | 0.00114(0.00108–0.00121) | 0.00107(0.00100–0.00117) | 0.00097(0.00092–0.00102) | ||
| Lt.AR | term | 0.00096(0.00091–0.00101) | 0.00088(0.00083–0.00093) | 0.00084(0.00080–0.00089) | 0.250 |
| preterm | 0.00097(0.00090–0.00104) | 0.00091(0.00086–0.00096) | 0.00085(0.00082–0.00090) | ||
| Lt.V1-V4 | term | 0.00117(0.00109–0.00127) | 0.00108(0.00101–0.00116) | 0.00100(0.00096–0.00110) | 0.298 |
| preterm | 0.00123(0.00111–0.00140) | 0.00112(0.00100–0.00127) | 0.00102(0.00095–0.00115) | ||
| SCC | term | 0.00112(0.00103–0.00119) | 0.00103(0.00095–0.00112) | 0.00095(0.00084–0.00105) | 0.304 |
| preterm | 0.00117(0.00104–0.00131) | 0.00107(0.00096–0.00118) | 0.00096(0.00083–0.00115) | ||
| Lt.UNC | term | 0.00105(0.00101–0.00108) | 0.00097(0.00094–0.00101) | 0.00092(0.00089–0.00094) | 0.326 |
| preterm | 0.00108(0.00100–0.00119) | 0.00099(0.00094–0.00105) | 0.00092(0.00087–0.00096) | ||
| Rt.IFO | term | 0.00106(0.00100–0.00112) | 0.00098(0.00094–0.00102) | 0.00092(0.00089–0.00096) | 0.375 |
| preterm | 0.00109(0.00101–0.00127) | 0.00100(0.00094–0.00111) | 0.00093(0.00089–0.00098) | ||
| Rt.UNC | term | 0.00106(0.00102–0.00110) | 0.00098(0.00093–0.00102) | 0.00092(0.00088–0.00096) | 0.469 |
| preterm | 0.00108(0.00096–0.00119) | 0.00100(0.00095–0.00107) | 0.00093(0.00089–0.00098) | ||
| Lt.Premotor-PMC | term | 0.00107(0.00101–0.00111) | 0.00099(0.00094–0.00103) | 0.00094(0.00087–0.00101) | 0.507 |
| preterm | 0.00110(0.00101–0.00123) | 0.00101(0.00093–0.00110) | 0.00095(0.00088–0.00102) | ||
| Rt.Thal-PSC | term | 0.00097(0.00089–0.00102) | 0.00088(0.00083–0.00093) | 0.00083(0.00076–0.00088) | 1.000 |
| preterm | 0.00099(0.00090–0.00108) | 0.00090(0.00083–0.00098) | 0.00084(0.00080–0.00090) | ||
| Rt.Premotor-PMC | term | 0.00108(0.00100–0.00113) | 0.00098(0.00094–0.00104) | 0.00094(0.00087–0.00098) | 1.000 |
| preterm | 0.00111(0.00103–0.00124) | 0.00101(0.00093–0.00110) | 0.00094(0.00089–0.00104) | ||
| Rt.AR | term | 0.00094(0.00090–0.00100) | 0.00088(0.00082–0.00095) | 0.00084(0.00077–0.00090) | 1.000 |
| preterm | 0.00095(0.00088–0.00106) | 0.00090(0.00082–0.00095) | 0.00085(0.00080–0.00089) | ||
| Rt.V1-V4 | term | 0.00118(0.00107–0.00129) | 0.00108(0.00102–0.00117) | 0.00100(0.00094–0.00110) | 1.000 |
| preterm | 0.00122(0.00107–0.00137) | 0.00111(0.00097–0.00126) | 0.00103(0.00092–0.00118) | ||
| Lt.OR | term | 0.00102(0.00088–0.00108) | 0.00091(0.00082–0.00101) | 0.00085(0.00077–0.00092) | 1.000 |
| preterm | 0.00104(0.00092–0.00121) | 0.00094(0.00082–0.00108) | 0.00087(0.00079–0.00095) | ||
| MCP | term | 0.00106(0.00099–0.00113) | 0.00097(0.00091–0.00105) | 0.00091(0.00081–0.00100) | 1.000 |
| preterm | 0.00108(0.00099–0.00115) | 0.00100(0.00091–0.00106) | 0.00091(0.00073–0.00098) | ||
| Lt.Thal-PSC | term | 0.00101(0.00094–0.00105) | 0.00092(0.00086–0.00096) | 0.00086(0.00082–0.00090) | 1.000 |
| preterm | 0.00102(0.00094–0.00112) | 0.00094(0.00087–0.00102) | 0.00086(0.00081–0.00092) | ||
| Rt.CG | term | 0.00115(0.00109–0.00123) | 0.00107(0.00102–0.00113) | 0.00098(0.00091–0.00104) | 1.000 |
| preterm | 0.00115(0.00108–0.00125) | 0.00108(0.00101–0.00118) | 0.00098(0.00091–0.00104) | ||
| Rt.V1-MT | term | 0.00122(0.00112–0.00131) | 0.00111(0.00102–0.00118) | 0.00103(0.00094–0.00114) | 1.000 |
| preterm | 0.00124(0.00112–0.00136) | 0.00112(0.00099–0.00125) | 0.00104(0.00092–0.00121) | ||
| Rt.OR | term | 0.00110(0.00097–0.00116) | 0.00098(0.00088–0.00105) | 0.00092(0.00085–0.00099) | 1.000 |
| preterm | 0.00111(0.00099–0.00127) | 0.00100(0.00086–0.00114) | 0.00092(0.00084–0.00107) | ||
| Rt.CST | term | 0.00093(0.00088–0.00100) | 0.00087(0.00080–0.00095) | 0.00082(0.00074–0.00092) | 1.000 |
| preterm | 0.00095(0.00087–0.00109) | 0.00088(0.00077–0.00097) | 0.00082(0.00073–0.00095) | ||
| Lt.IFO | term | 0.00103(0.00098–0.00111) | 0.00095(0.00089–0.00101) | 0.00090(0.00086–0.00096) | 1.000 |
| preterm | 0.00104(0.00095–0.00123) | 0.00096(0.00090–0.00101) | 0.00090(0.00084–0.00094) | ||
| Lt.CST | term | 0.00084(0.00081–0.00089) | 0.00079(0.00072–0.00082) | 0.00074(0.00068–0.00079) | 1.000 |
| preterm | 0.00085(0.00078–0.00094) | 0.00079(0.00072–0.00086) | 0.00073(0.00066–0.00082) | ||
2. Experimental design, materials and methods
2.1. Experimental design
The probabilistic maps of pathways related to motor, somatosensory, auditory, visual, and limbic functions, and major white matter tracts (the corpus callosum, the inferior fronto-occipital fasciculus, and the middle cerebellar peduncle) [1] (freely downloadable from (http://cmrm.med.jhmi.edu/)) were applied to evaluate the developmental trajectories of these tracts, using longitudinal diffusion tensor imaging obtained in term-born and preterm-born infants. The FA, e0, e1, e2, and radial diffusivity were measured at each time point.
2.2. Participants
Eighty-four term-born and preterm-born infants were enrolled. The infants׳ parents or legal guardians first provided written and verbal informed consent for the study, which was approved by the Co-operative Institutional Review Board of the Queen׳s Medical Center, the University of Hawaii, and the Johns Hopkins University. Nineteen healthy term-born and 30 preterm-born infants completed the longitudinal study and were clinically evaluated by a physician to ensure they fulfilled the study criteria. Maternal exclusion criteria were: 1) Maternal age<18 years; and 2) Inability to fully understand English, which precluded informed consent. Exclusion criteria for the term-born infants included: 1) Prolonged intensive care (>7 days); 2) Intracranial hemorrhage; 3) Neonatal encephalopathy; 4) Known TORCH infection; and 5) Congenital anomaly. Preterm-born infants were excluded if they 1) required supplementary oxygen or mechanical ventilation during the time of scanning; 2) had a circulation, respiratory, or airway abnormality; or 3) were diagnosed with fever, epilepsy, or active infection. These infants also were evaluated with a modified Amiel-Tison Neurological Assessment for newborns, and all had usable MR scans at three time points: Time-point 1, 41.6±2.7 postmenstrual weeks; Time-point 2, 46.0±2.9 postmenstrual weeks; and Time point 3, 50.8±3.7 postmenstrual weeks.
2.3. MRI scans
The infants were scanned during natural sleep without sedation. A single-shot echo planer imaging (EPI) acquisition with sensitivity encoding (SENSE) was acquired using a 3T Siemens TIM Trio scanner. The parameters were: matrix, 80×80; field-of-view, 160×160 mm; 2.5 mm thickness; echo-time, 106 ms; and repetition time, 7 to 9 s. Diffusion-weighting was applied along 12 independent axes with b=1000 s/mm2, in addition to a minimally diffusion-weighted image.
2.4. Image processing
The diffusion tensor was calculated using DtiStudio. Each DTI was transformed to the JHU-neonate DTI atlas [4] using dual-channel large deformation diffeomorphic metric mapping (LDDMM) as detailed previously [2], [3], [4].
3. Application of the probabilistic maps to DTI of term- and preterm-born infants
The average of each of the scalar values (FA, e0, e1, e2, and radial diffusivity) at each white matter pathway, with a probability of more than 75%, was measured for each infant at each time point using the probabilistic maps. For each pathway, a mixed model analysis for repeated measures was performed to investigate chronological changes in the trace values related to brain development over the three time points, and the difference between groups (preterm-born versus term-born groups, and boys versus girls). The infant׳s age in postmenstrual weeks at the time of the scans was used as a covariate to adjust for variation at each time point. A p-value of 0.05, corrected for multiple comparisons (Bonferroni), was used as the threshold. SPSS Statistics 22 (IBM, Armonk, NY) was used for the statistical analyses.
Acknowledgments
This publication was made possible by grants R01HD065955, 2K24DA16170, U54NS056883, G12MD007601-26 and P41EB015909 from the National Institutes of Health, grant 46039500 from the Central Norway Regional Health Authority, and the Uehara Memorial Foundation. The contents of this paper are solely the responsibility of the authors and do not necessarily represent the official view of NIH, the Central Norway Regional Health Authority, or the Uehara Memorial Foundation. The authors are grateful to the families of our research participants, pediatricians/neonatologists (Dr. Lillian Fujimoto, Dr. Lois Chiu, and Dr. Joseph Hudak), and our research staff (Heather Johansen, Antonette Hernandez, and Caroline Jiang), who assisted with the data collection and data transfer. We also thank Ms. Mary McAllister for help with manuscript editing, Mr. Rajiv Deshpande for technical support, Dr. Susumu Mori for advice about the DTI scans, and Dr. Doris Lin for image reading and reporting as a neuroradiologist certified by the American Board of Neuroradiology.
Footnotes
Supplementary data associated with this article can be found in the online version at 10.1016/j.dib.2016.01.064.
Appendix A. Supplementary material
Supplementary material
References
- 1.Akazawa K., Chang L., Yamakawa R., Hayama S., Buchthal S., Alicata D., Andres T., Castillo D., Oishi K., Skranes J., Ernst T., Oishi K. Probabilistic maps of the white matter tracts with known associated functions on the neonatal brain atlas: application to evaluate longitudinal developmental trajectories in term and preterm born infants. Neuroimage. 2016;128:167–179. doi: 10.1016/j.neuroimage.2015.12.026. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 2.Ceritoglu C., Oishi K., Li X., Chou M.C., Younes L., Albert M., Lyketsos C., van Zijl P.C., Miller M.I., Mori S. Multi-contrast large deformation diffeomorphic metric mapping for diffusion tensor imaging. Neuroimage. 2009;47:618–627. doi: 10.1016/j.neuroimage.2009.04.057. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 3.Oishi K., Faria A., Jiang H., Li X., Akhter K., Zhang J., Hsu J.T., Miller M.I., van Zijl P.C., Albert M., Lyketsos C.G., Woods R., Toga A.W., Pike G.B., Rosa-Neto P., Evans A., Mazziotta J., Mori S. Atlas-based whole brain white matter analysis using large deformation diffeomorphic metric mapping: application to normal elderly and Alzheimer׳s disease participants. Neuroimage. 2009;46:486–499. doi: 10.1016/j.neuroimage.2009.01.002. [DOI] [PMC free article] [PubMed] [Google Scholar]
- 4.Oishi K., Mori S., Donohue P.K., Ernst T., Anderson L., Buchthal S., Faria A., Jiang H., Li X., Miller M.I., van Zijl P.C., Chang L. Multi-contrast human neonatal brain atlas: application to normal neonate development analysis. Neuroimage. 2011;56:8–20. doi: 10.1016/j.neuroimage.2011.01.051. [DOI] [PMC free article] [PubMed] [Google Scholar]
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Supplementary Materials
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