Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1977 Feb;30(2):132–137. doi: 10.1136/jcp.30.2.132

Alpha-1-antitrypsin bodies in the liver.

W K Blenkinsopp, G P Haffenden
PMCID: PMC476335  PMID: 191472

Abstract

The cytoplasmic bodies in hepatocytes thought to indicate possession of the Z allele for alpha 1-antitrypsin deficiency were found in necropsy in 10 of 64 adults with cirrhosis, four of nine with hepatic fibrosis, and four of 15 with hepatocellular carcinoma. They were also found in six of 76 adults with severe panacinar emphysema, and in four of a control series of 110 adults with neither emphysema nor liver disease. The association of the bodies with each of the three liver diseases was statistically significant, but the association of the bodies with emphysema was not. It is considered probable that heterozygous (PiMZ) alpha 1-antitrypsin deficiency is associated with an increased incidence of cirrhosis, hepatic fibrosis, and hepatocellular carcinoma.

Full text

PDF
132

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BIAVA C. ELECTRON MICROSCOPIC STUDIES ON PERIODIC ACID-SCHIFF-POSITIVE NONGLYCOGENIC STRUCTURES IN HUMAN LIVER CELLS. Am J Pathol. 1965 Mar;46:435–465. [PMC free article] [PubMed] [Google Scholar]
  2. Berg N. O., Eriksson S. Liver disease in adults with alpha-1 -antitrypsin deficiency. N Engl J Med. 1972 Dec 21;287(25):1264–1267. doi: 10.1056/NEJM197212212872502. [DOI] [PubMed] [Google Scholar]
  3. Burns J. Background staining and sensitivity of the unlabelled antibody-enzyme (PAP) method. Comparison with the peroxidase labelled antibody sandwich method using formalin fixed paraffin embedded material. Histochemistry. 1975 Jun 5;43(3):291–294. doi: 10.1007/BF00499711. [DOI] [PubMed] [Google Scholar]
  4. Campra J. L., Craig J. R., Peters R. L., Reynolds T. B. Cirrhosis associated with partial deficiency of alpha-1 antitrypsin in an adult. Ann Intern Med. 1973 Feb;78(2):233–238. doi: 10.7326/0003-4819-78-2-233. [DOI] [PubMed] [Google Scholar]
  5. Cook P. J. Genetic aspects of the Pi system. Postgrad Med J. 1974 Jun;50(584):362–364. doi: 10.1136/pgmj.50.584.362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Craig J. R., Dunn A. E., Peters R. L. Cirrhosis associated with partial deficiency of alpha-1-antitrypsin: a clinical and autopsy study. Hum Pathol. 1975 Jan;6(1):113–120. doi: 10.1016/s0046-8177(75)80112-2. [DOI] [PubMed] [Google Scholar]
  7. Crawford I. P., Dawson A., Stevenson D. D. Alpha 1-antitrypsin deficiency associated with PZ and MP phenotypes. Clinical and laboratory correlations. Am J Med. 1974 Aug;57(2):210–216. doi: 10.1016/0002-9343(74)90445-8. [DOI] [PubMed] [Google Scholar]
  8. Eriksson S., Hägerstrand I. Cirrhosis and malignant hepatoma in alpha 1-antitrypsin deficiency. Acta Med Scand. 1974 Jun;195(6):451–458. doi: 10.1111/j.0954-6820.1974.tb08170.x. [DOI] [PubMed] [Google Scholar]
  9. Eriksson S., Moestrup T., Hägerstrand I. Liver, lung and malignant disease in heterozygous (Pi MZ) alpha1-antitrypsin deficiency. Acta Med Scand. 1975 Oct;198(4):243–247. doi: 10.1111/j.0954-6820.1975.tb19535.x. [DOI] [PubMed] [Google Scholar]
  10. Feldmann G., Martin J. P., Sesboue R., Ropartz C., Perelman R., Nathanson M., Seringe P., Benhamou J. P. The ultrastructure of hepatocytes in alpha-1-antitrypsin deficiency with the genotype Pi--. Gut. 1975 Oct;16(10):796–799. doi: 10.1136/gut.16.10.796. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gordon H. W., Dixon J., Rogers J. C., Mittman C., Lieberman J. Alpha 1 -antitrypsin (A1AT) accumulation in livers of emphysematous patients with A1AT deficiency. Hum Pathol. 1972 Sep;3(3):361–370. doi: 10.1016/s0046-8177(72)80037-6. [DOI] [PubMed] [Google Scholar]
  12. Kueppers F., Fallat R., Larson R. K. Obstructive lung disease and alpha-1-antitrypsin deficiency gene heterozygosity. Science. 1969 Aug 29;165(3896):899–901. doi: 10.1126/science.165.3896.899. [DOI] [PubMed] [Google Scholar]
  13. Lieberman J. Alpha 1 -antitrypsin deficiency. Med Clin North Am. 1973 May;57(3):691–706. doi: 10.1016/s0025-7125(16)32268-4. [DOI] [PubMed] [Google Scholar]
  14. Lieberman J., Mittman C., Gordon H. W. Alpha 1 antitrypsinin the livers of patients with emphysema. Science. 1972 Jan 7;175(4017):63–65. doi: 10.1126/science.175.4017.63. [DOI] [PubMed] [Google Scholar]
  15. Lieberman J., Silton R. M., Agliozzo C. M., McMahon J. Hepatocellular carcinoma and intermediate alpha1-antitrypsin deficiency (MZ phenotype). Am J Clin Pathol. 1975 Sep;64(3):304–310. doi: 10.1093/ajcp/64.3.304. [DOI] [PubMed] [Google Scholar]
  16. Martin J. P., Charlionet R., Sesboüe R., Ropartz C. Letter: Alpha1-antitrypsin deficiency. Lancet. 1976 Feb 21;1(7956):434–434. doi: 10.1016/s0140-6736(76)90284-1. [DOI] [PubMed] [Google Scholar]
  17. Morin T., Martin J. P., Feldmann G., Rueff B., Benhamou J. P., Ropartz C. Heterozygous alpha 1-antitrypsin deficiency and cirrhosis in adults, a fortuitous association. Lancet. 1975 Feb 1;1(7901):250–251. doi: 10.1016/s0140-6736(75)91143-5. [DOI] [PubMed] [Google Scholar]
  18. Nakane P. K. Simultaneous localization of multiple tissue antigens using the peroxidase-labeled antibody method: a study on pituitary glands of the rat. J Histochem Cytochem. 1968 Sep;16(9):557–560. doi: 10.1177/16.9.557. [DOI] [PubMed] [Google Scholar]
  19. Norkin S. A., Campagna-Pinto D. Cytoplasmic hyaline inclusions in hepatoma. Histochemical study. Arch Pathol. 1968 Jul;86(1):25–32. [PubMed] [Google Scholar]
  20. POPPER H., PARONETTO F., BARKA T. PAS-positive structures of nonglycogenic character in normal and abnormal liver. Arch Pathol. 1960 Sep;70:300–313. [PubMed] [Google Scholar]
  21. Palmer P. E., Wolfe H. J. Alpha-antitrypsin deposition in primary hepatic carcinomas. Arch Pathol Lab Med. 1976 May;100(5):232–236. [PubMed] [Google Scholar]
  22. Palmer P. E., Wolfe H. J., Gherardi G. J. Hepatic changes in adult alpha-1-antitrypsin deficiency. Gastroenterology. 1973 Aug;65(2):284–293. [PubMed] [Google Scholar]
  23. Rawlings W., Jr, Moss J., Cooper H. S., Hamilton S. R. Hepatocellular carcinoma and partial deficiency of alpha-1 antitrypsin (MZ). Ann Intern Med. 1974 Dec;81(6):771–773. doi: 10.7326/0003-4819-81-6-771. [DOI] [PubMed] [Google Scholar]
  24. Sharp H. L. The current status of alpha-1-antityrpsin, a protease inhibitor, in gastrointestinal disease. Gastroenterology. 1976 Apr;70(4):611–621. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES