Abstract
An outbreak of infection caused by a strain of Staphylococcus aureus resistant to gentamicin and tobramycin and other antibiotics occurred in two wards in a hospital. Eight patients were colonized, of whom six had clinical infections. Previous administration of gentamicin appeared to predispose the patients to infection with the strain. Restriction of the use of gentamicin and tobramycin is essential to preserve their value in serious infections.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Alder V. G., Gillespie W. A. Influence of neomycin sprays on the spread of resistant staphylococci. Lancet. 1967 Nov 18;2(7525):1062–1063. doi: 10.1016/s0140-6736(67)90337-6. [DOI] [PubMed] [Google Scholar]
- Broughall J. M., Reeves D. S. The acetyltransferase enzyme method for the assay of serum gentamicon concentrations and a comparison with other methods. J Clin Pathol. 1975 Feb;28(2):140–145. doi: 10.1136/jcp.28.2.140. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Datta N. Infection caused by Proteus mirabilis strains with transferrable gentamicin-resistance factors. Lancet. 1975 Jun 21;1(7921):1355–1357. doi: 10.1016/s0140-6736(75)92262-x. [DOI] [PubMed] [Google Scholar]
- Greene W. H., Moody M., Schimpff S., Young V. M., Wiernik P. H. Pseudomonas aeruginosa resistant to carbenicillin and gentamicin. Epidemiologic and clinical aspects in a cancer center. Ann Intern Med. 1973 Nov;79(5):684–689. doi: 10.7326/0003-4819-79-5-684. [DOI] [PubMed] [Google Scholar]
- LOWBURY E. J., BABB J. R., BROWN V. L., COLLINS B. J. NEOMYCIN-RESISTANT STAPHYLOCOCCUS AUREUS IN A BURNS UNIT. J Hyg (Lond) 1964 Jun;62:221–228. doi: 10.1017/s0022172400039942. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lacey R. W. Antibiotic resistance plasmids of Staphylococcus aureus and their clinical importance. Bacteriol Rev. 1975 Mar;39(1):1–32. doi: 10.1128/br.39.1.1-32.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lacey R. W. Genetic basis, epidemiology, and future significance of antibiotic resistance in Staphylococcus aureus: a review. J Clin Pathol. 1973 Dec;26(12):899–913. doi: 10.1136/jcp.26.12.899. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lacey R. W. Genetic control in methicillin-resistant strains of Staphylococcus aureus. J Med Microbiol. 1972 Nov;5(4):497–508. doi: 10.1099/00222615-5-4-497. [DOI] [PubMed] [Google Scholar]
- Porthouse A., Brown D. F., Smith R. G., Rogers T. Gentamicin resistance in Staphylococcus aureus. Lancet. 1976 Jan 3;1(7949):20–21. doi: 10.1016/s0140-6736(76)92912-3. [DOI] [PubMed] [Google Scholar]
- Soussy C. J., Bouanchaud D. H., Fouace J., Dublanchet A., Duval J. A gentamycin resistance plasmid in Staphylococcus aureus. Ann Microbiol (Paris) 1975 Jul-Aug;126B(1):91–94. [PubMed] [Google Scholar]
- Speller D. C., Raghunath D., Stephens M., Viant A. C., Reeves D. S., Wilkinson P. J., Broughall J. M., Holt H. A. Epidemic infection by a gentamicin-resistant Staphylococcus aureus in three hospitals. Lancet. 1976 Feb 28;1(7957):464–466. doi: 10.1016/s0140-6736(76)91485-9. [DOI] [PubMed] [Google Scholar]
- Warren R. E., Roberts S. O. Letter: Gentamicin-resistant Staphylococci. Lancet. 1976 Mar 6;1(7958):543–544. doi: 10.1016/s0140-6736(76)90336-6. [DOI] [PubMed] [Google Scholar]
- Whitelaw A. G., Holzel H., Farrag N. N. Letter: Gentamicin-resistant escherichia coli. Br Med J. 1974 Jun 15;2(5919):613–613. doi: 10.1136/bmj.2.5919.613-a. [DOI] [PMC free article] [PubMed] [Google Scholar]