Abstract
Forty-three examples of cribriform adenocarcinoma (adenoid cystic carcinoma) of mixed glandular origin are reported. Structural studies emphasise the classical cribriform pattern which indicates the capacity of this neoplasm to behave as both an epithelial and a connective tissue type tumour. In terms of survival, it does not appear to be an malignant as other forms of carcinoma arising in similar anatomical locations. The five-year crude survival rate (56%) compares favourably with that of other carcinomas of the palate and paranasal sinuses. A recurrence rate of the order of 20% may persist up to 10 years after primary treatment, and while this is not inimical to longer survival there is clearly a high morbidity.
Full text
PDFImages in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- AZZOPARDI J. G., SMITH O. D. Salivary gland tumours and their mucins. J Pathol Bacteriol. 1959 Jan;77(1):131–140. doi: 10.1002/path.1700770114. [DOI] [PubMed] [Google Scholar]
- BELSEY R. H. R., VALENTINE J. C. Cylindromatous mucous-gland tumours of the trachea and bronchi: a report of three cases. J Pathol Bacteriol. 1951 Jul;63(3):377–387. doi: 10.1002/path.1700630303. [DOI] [PubMed] [Google Scholar]
- BERDAL P., MYLIUS E. Cylindromas of the respiratory tract, the upper part of the digestive tract and adjoining organs. Acta Otolaryngol Suppl. 1954;118:32–44. doi: 10.3109/00016485409123993. [DOI] [PubMed] [Google Scholar]
- BHASKAR S. N., WEINMANN J. P. Tumors of the minor salivary glands; a study of twenty-three cases. Oral Surg Oral Med Oral Pathol. 1955 Dec;8(12):1278–1297. doi: 10.1016/0030-4220(55)90433-3. [DOI] [PubMed] [Google Scholar]
- Bergman F. Tumors of the minor salivary glands. A report of 46 cases. Cancer. 1969 Mar;23(3):538–543. doi: 10.1002/1097-0142(196903)23:3<538::aid-cncr2820230304>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
- CHAUDHRY A. P., VICKERS R. A., GORLIN R. J. Intraoral minor salivary gland tumors. An analysis of 1,414 cases. Oral Surg Oral Med Oral Pathol. 1961 Oct;14:1194–1226. doi: 10.1016/0030-4220(61)90209-2. [DOI] [PubMed] [Google Scholar]
- DANCOT H. Les cylindromes des glandes salivaires; etude de 19 cas. Bull Assoc Fr Etud Cancer. 1953;40(3):383–396. [PubMed] [Google Scholar]
- EDWARDS E. G. Tumors of the minor salivary glands. A report of 23 cases. Am J Clin Pathol. 1960 Nov;34:455–463. doi: 10.1093/ajcp/34.5.455. [DOI] [PubMed] [Google Scholar]
- Eneroth C. M., Hjertman L., Moberger G. Malignant tumours of the submandibular gland. Acta Otolaryngol. 1967 Nov-Dec;64(5):514–536. doi: 10.3109/00016486709139137. [DOI] [PubMed] [Google Scholar]
- Eneroth C. M., Hjertman L., Moberger G., Wersäll J. Ultrastructural characteristics of adenoid cystic carcinoma of salivary glands. Arch Klin Exp Ohren Nasen Kehlkopfheilkd. 1968;192(4):358–368. doi: 10.1007/BF00411131. [DOI] [PubMed] [Google Scholar]
- FINE G., MARSHALL R. B., HORN R. C., Jr Tumors of the minor salivary glands. Cancer. 1960 Jul-Aug;13:653–669. doi: 10.1002/1097-0142(196007/08)13:4<653::aid-cncr2820130403>3.0.co;2-0. [DOI] [PubMed] [Google Scholar]
- Friborský V. Submicroscopical structure of adenoid cystic carcinoma of salivary glands. Acta Morphol Acad Sci Hung. 1966;14(1):105–115. [PubMed] [Google Scholar]
- Hamperl H. The myothelia (myoepithelial cells). Normal state; regressive changes; hyperplasia; tumors. Curr Top Pathol. 1970;53:161–220. [PubMed] [Google Scholar]
- Koss L. G., Spiro R. H., Hajdu S. Small cell (oat cell) carcinoma of minor salivary gland origin. Cancer. 1972 Sep;30(3):737–741. doi: 10.1002/1097-0142(197209)30:3<737::aid-cncr2820300322>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
- NAYER H. R. Case report section; cylindroma of the breast with pulmonary metastases. Dis Chest. 1957 Mar;31(3):324–327. doi: 10.1378/chest.31.3.324. [DOI] [PubMed] [Google Scholar]
- Osborn D. A. Nature and behavior of transitional tumors in the upper respiratory tract. Cancer. 1970 Jan;25(1):50–60. doi: 10.1002/1097-0142(197001)25:1<50::aid-cncr2820250109>3.0.co;2-a. [DOI] [PubMed] [Google Scholar]
- Potdar G. G., Paymaster J. C. Tumors of minor salivary glands. Oral Surg Oral Med Oral Pathol. 1969 Sep;28(3):310–319. doi: 10.1016/0030-4220(69)90220-5. [DOI] [PubMed] [Google Scholar]
- RANGER D., THACKRAY A. C., LUCAS R. B. Mucous gland tumours. Br J Cancer. 1956 Mar;10(1):1–16. doi: 10.1038/bjc.1956.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
- REID J. D. Adenoid cystic carcinoma (cylindroma) of the bronchial tree. Cancer. 1952 Jul;5(4):685–694. doi: 10.1002/1097-0142(195207)5:4<685::aid-cncr2820050406>3.0.co;2-9. [DOI] [PubMed] [Google Scholar]
- RUSSELL H. Adenomatous tumours of the anterior foregut region showing the cylindroma pattern. Br J Surg. 1955 Nov;43(179):248–254. doi: 10.1002/bjs.18004317903. [DOI] [PubMed] [Google Scholar]
- SABATINI D. D., BENSCH K., BARRNETT R. J. Cytochemistry and electron microscopy. The preservation of cellular ultrastructure and enzymatic activity by aldehyde fixation. J Cell Biol. 1963 Apr;17:19–58. doi: 10.1083/jcb.17.1.19. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SMITH A. G., BROADBENT T. R., ZAVALETA A. A. Tumors of oral mucous glands. Cancer. 1954 Mar;7(2):224–233. doi: 10.1002/1097-0142(195403)7:2<224::aid-cncr2820070204>3.0.co;2-5. [DOI] [PubMed] [Google Scholar]
- SMITH J. F. Tumors of the minor salivary glands. Oral Surg Oral Med Oral Pathol. 1962 May;15:594–602. doi: 10.1016/0030-4220(62)90179-2. [DOI] [PubMed] [Google Scholar]
- STRUBEN W. H., HAMPE J. F. Cylindromas of the upper respiratory tract. J Laryngol Otol. 1959 Nov;73:722–731. doi: 10.1017/s0022215100055948. [DOI] [PubMed] [Google Scholar]
- Smith L. C., Lane N., Rankow R. M. Cylindroma (adenoid cystic carcinoma). A report of fifty-eight cases. Am J Surg. 1965 Oct;110(4):519–526. doi: 10.1016/0002-9610(65)90030-9. [DOI] [PubMed] [Google Scholar]
- Spiro R. H., Koss L. G., Hajdu S. I., Strong E. W. Tumors of minor salivary origin. A clinicopathologic study of 492 cases. Cancer. 1973 Jan;31(1):117–129. doi: 10.1002/1097-0142(197301)31:1<117::aid-cncr2820310116>3.0.co;2-7. [DOI] [PubMed] [Google Scholar]
- Stuteville O. H., Corley R. D. Surgical management of tumors of intraoral minor salivary glands. Report of eighty cases. Cancer. 1967 Oct;20(10):1578–1586. doi: 10.1002/1097-0142(196710)20:10<1578::aid-cncr2820201003>3.0.co;2-4. [DOI] [PubMed] [Google Scholar]
- TAUXE W. N., McDONALD J. R., DEVINE K. D. A century of cylindromas. Short review and report of 27 adenoid cystic carcinomas arising in the upper respiratory passages. Arch Otolaryngol. 1962 Apr;75:364–376. doi: 10.1001/archotol.1962.00740040373009. [DOI] [PubMed] [Google Scholar]
- THACKRAY A. C., LUCAS R. B. The histology of cylindroma of mucous gland origin. Br J Cancer. 1960 Dec;14:612–620. doi: 10.1038/bjc.1960.67. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Tandler B. Ultrastructure of adenoid cystic carcinoma of salivary gland origin. Lab Invest. 1971 Jun;24(6):504–512. [PubMed] [Google Scholar]