Abstract
In a histological study of biopsy and postmortem material from 30 cases of nasal disease in which a clinical diagnosis of 'midline granuloma' or Wegener's granuloma had been given, we selected 10 cases on the basis of the presence of widespread coagulative necrosis and atypical cells. Evidence is provided that such changes represent a malignant neoplasm of histiocytic lymphoma type. Local invasion and spread to cervical and more distant lymph nodes, spleen, liver, and kidney were seen in some of the cases. Erythrophagocytic activity was marked in the spleen in three cases and histiocytic infiltration of the bone marrow in two cases, indicating a more generalised activity of histiocytic cells. Terms such as 'malignant granuloma' should be abandoned. In obstructive and ulcerating conditions of the nose efforts should be concentrated on making an accurate histological diagnosis.
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- BURSTON H. H. Lethal midline granuloma: is it a pathological entity. Laryngoscope. 1959 Jan;69(1):1–43. doi: 10.1288/00005537-195901000-00001. [DOI] [PubMed] [Google Scholar]
- Dorfman R. F. Letter: Classification of non-Hodgkin's lymphomas. Lancet. 1974 Jun 22;1(7869):1295–1296. doi: 10.1016/s0140-6736(74)90061-0. [DOI] [PubMed] [Google Scholar]
- Eichel B. S., Harrison E. G., Jr, Devine K. D., Scanlon P. W., Brown H. A. Primary lymphoma of the nose including a relationship to lethal midline granuloma. Am J Surg. 1966 Oct;112(4):597–605. doi: 10.1016/0002-9610(66)90328-x. [DOI] [PubMed] [Google Scholar]
- Eichel B. S., Mabery T. E. The enigma of the lethal midline granuloma. Laryngoscope. 1968 Aug;78(8):1367–1386. doi: 10.1288/00005537-196808000-00008. [DOI] [PubMed] [Google Scholar]
- FRIEDMANN I. THE PATHOLOGY OF MIDLINE GRANULOMA. Proc R Soc Med. 1964 Apr;57:289–297. [PMC free article] [PubMed] [Google Scholar]
- FRIEDMANN I. The pathology of malignant granuloma of the nose. J Laryngol Otol. 1955 May;69(5):331–341. doi: 10.1017/s0022215100050751. [DOI] [PubMed] [Google Scholar]
- Harrison D. F. Non-healing granulomata of the upper respiratory tract. Br Med J. 1974 Oct 26;4(5938):205–209. doi: 10.1136/bmj.4.5938.205. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LOPES DE FARIA J., CUTIN M., MORGANTE A. P., FERRI R. G. Malignant granuloma of the face; contribution to its nosology. AMA Arch Otolaryngol. 1957 Mar;65(3):255–262. doi: 10.1001/archotol.1957.03830210053008. [DOI] [PubMed] [Google Scholar]
- McGuirt W. F., Rose E. F. Lethal midline granuloma: a pathological spectrum. J Laryngol Otol. 1976 May;90(5):459–466. doi: 10.1017/s0022215100082311. [DOI] [PubMed] [Google Scholar]
- SMITH F. Erythrophagocytosis in human lymph-glands. J Pathol Bacteriol. 1958 Oct;76(2):383–392. doi: 10.1002/path.1700760207. [DOI] [PubMed] [Google Scholar]