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. 1977 May;30(5):464–466. doi: 10.1136/jcp.30.5.464

Alpha-1-antitrypsin globules in the liver and PiM phenotype.

J W Bradfield, W K Blenkinsopp
PMCID: PMC476441  PMID: 301146

Abstract

The finding is recorded of typical a1-antitrypsin globules, confirmed by immunofluorescence and immunoperoxidase methods, in the hepatocytes of a patient shown to have a normal serum antitrypsin level and normal phenotype (TiM) for a1-antitrypsin. The identification of such globules can no longer be regarded as conclusive evidence of an abnormal a1-antitrypsin phenotype.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Blenkinsopp W. K., Haffenden G. P. Alpha-1-antitrypsin bodies in the liver. J Clin Pathol. 1977 Feb;30(2):132–137. doi: 10.1136/jcp.30.2.132. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cook P. J. Genetic aspects of the Pi system. Postgrad Med J. 1974 Jun;50(584):362–364. doi: 10.1136/pgmj.50.584.362. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Cook P. J. The genetics of alpha1-antitrypsin: a family study in England and Scotland. Ann Hum Genet. 1975 Jan;38(3):275–287. doi: 10.1111/j.1469-1809.1975.tb00611.x. [DOI] [PubMed] [Google Scholar]
  4. Eriksson S., Moestrup T., Hägerstrand I. Liver, lung and malignant disease in heterozygous (Pi MZ) alpha1-antitrypsin deficiency. Acta Med Scand. 1975 Oct;198(4):243–247. doi: 10.1111/j.0954-6820.1975.tb19535.x. [DOI] [PubMed] [Google Scholar]
  5. Feldmann G., Martin J. P., Sesboue R., Ropartz C., Perelman R., Nathanson M., Seringe P., Benhamou J. P. The ultrastructure of hepatocytes in alpha-1-antitrypsin deficiency with the genotype Pi--. Gut. 1975 Oct;16(10):796–799. doi: 10.1136/gut.16.10.796. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gordon H. W., Dixon J., Rogers J. C., Mittman C., Lieberman J. Alpha 1 -antitrypsin (A1AT) accumulation in livers of emphysematous patients with A1AT deficiency. Hum Pathol. 1972 Sep;3(3):361–370. doi: 10.1016/s0046-8177(72)80037-6. [DOI] [PubMed] [Google Scholar]
  7. Lieberman J., Mittman C., Gordon H. W. Alpha 1 antitrypsinin the livers of patients with emphysema. Science. 1972 Jan 7;175(4017):63–65. doi: 10.1126/science.175.4017.63. [DOI] [PubMed] [Google Scholar]
  8. Martin J. P., Charlionet R., Sesboüe R., Ropartz C. Letter: Alpha1-antitrypsin deficiency. Lancet. 1976 Feb 21;1(7956):434–434. doi: 10.1016/s0140-6736(76)90284-1. [DOI] [PubMed] [Google Scholar]
  9. Sharp H. L. The current status of alpha-1-antityrpsin, a protease inhibitor, in gastrointestinal disease. Gastroenterology. 1976 Apr;70(4):611–621. [PubMed] [Google Scholar]

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