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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1977 Jul;30(7):602–605. doi: 10.1136/jcp.30.7.602

Lack of evidence for mutation to erythromycin resistance in clinical strains of Staphylococcus aureus.

R W Lacey
PMCID: PMC476494  PMID: 886013

Abstract

The properties of 100 erythromycin resistant strains of Staphylococcus aureus obtained from clinical material have been compared with the properties of mutants selected in vitro for resistance to erythromycin. The properties, including inducibility of the resistance and cross-resistance to spiramycin and lincomycin, of the two groups of isolates were always different. The risk that staphylococci will mutate to erythromycin resistance during therapy with this antibiotic is remote.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. GARROD L. P. The erythromycin group of antibiotics. Br Med J. 1957 Jul 13;2(5036):57–63. doi: 10.1136/bmj.2.5036.57. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Jevons M. P., John M., Parker M. T. Cultural characters of a newly recognized group of hospital staphylococci. J Clin Pathol. 1966 Jul;19(4):305–312. doi: 10.1136/jcp.19.4.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Lacey R. W. Antibiotic resistance plasmids of Staphylococcus aureus and their clinical importance. Bacteriol Rev. 1975 Mar;39(1):1–32. doi: 10.1128/br.39.1.1-32.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Lacey R. W., Lewis E., Harrison J. Variation in the properties of a strain of Staphylococcus aureus isolated over three months from a single hospital. J Med Microbiol. 1975 Feb;8(1):39–46. doi: 10.1099/00222615-8-1-39. [DOI] [PubMed] [Google Scholar]
  5. Lacey R. W. Transfer of chromosomal genes between staphylococci in mixed cultures. J Gen Microbiol. 1972 Jul;71(2):399–401. doi: 10.1099/00221287-71-2-399. [DOI] [PubMed] [Google Scholar]
  6. WEAVER J. R., PATTEE P. A. INDUCIBLE RESISTANCE TO ERYTHROMYCIN IN STAPHYLOCOCCUS AUREUS. J Bacteriol. 1964 Sep;88:574–580. doi: 10.1128/jb.88.3.574-580.1964. [DOI] [PMC free article] [PubMed] [Google Scholar]

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