Abstract
Sucrose density gradient ultracentrifugation followed by haemagglutination inhibition for demonstrating specific influenza IgM was evaluated as a means of confirming recent infection with influenza A viruses. Specific IgM antibodies were found in at least one serum obtained from 83% of patients with proven recent infection with influenza A viruses but in none of the sera from 21 individuals without evidence of infection. Influenza IgM antibodies persisted for up to 112 days after infection. The relative merits of detecting specific IgM and complement fixing antibodies for diagnostic purposes are discussed.
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Selected References
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- Buchner Y. I., Heath R. B., Collins J. V., Pattison J. R. Detection of antibodies of the IgM class in sera of patients recently infected with influenza viruses. J Clin Pathol. 1976 May;29(5):423–427. doi: 10.1136/jcp.29.5.423. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Daugharty H., Davis M. L., Kaye H. S. Immunoglobulin class of influenza antibodies investigated by radioimmunoassay (RIA). J Immunol. 1972 Oct;109(4):849–856. [PubMed] [Google Scholar]
- Desmyter J., South M. A., Rawls W. E. The IgM antibody response in rubella during pregnancy. J Med Microbiol. 1971 Feb;4(1):107–114. doi: 10.1099/00222615-4-1-107. [DOI] [PubMed] [Google Scholar]
- Dobrovolskaya N. G. Formation of antibodies of different classes in influenzal infections. J Hyg Epidemiol Microbiol Immunol. 1971;15(2):148–155. [PubMed] [Google Scholar]
- Pattison J. R., Mace J. E. The detection of specific IgM antibodies following infection with rubella virus. J Clin Pathol. 1975 May;28(5):377–382. doi: 10.1136/jcp.28.5.377. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Urquhart G. E. Serum IgM and IgA responses in influenza A infections. J Clin Pathol. 1974 Mar;27(3):198–201. doi: 10.1136/jcp.27.3.198. [DOI] [PMC free article] [PubMed] [Google Scholar]