Abstract
Serial plasmaphereses were performed on a 23-year-old haemophiliac, with antibodies to factor VIII (FVIII), in order to reduce the antibody level before multiple dental extractions. Eight phereses were carried out in which approximately 1.5 litres plasma was exchanged with isotonic saline. By the ninth exchange, which was carried out immediately before the extraction, the antibody level had fallen from 4 u/ml to 0.8 u/ml. On this occasion fresh frozen plasma and FVIII concentrate were infused immediately after the pheresis. A normal post-infusion level of FVIII was achieved with a normal half disappearance time of the infused FVIII.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BIGGS R., BIDWELL E. A method for the study of antihaemophilic globulin inhibitors with reference to six cases. Br J Haematol. 1959 Oct;5:379–395. doi: 10.1111/j.1365-2141.1959.tb04049.x. [DOI] [PubMed] [Google Scholar]
- BIGGS R., EVELING J., RICHARDS G. The assay of antihaemophilic-globulin activity. Br J Haematol. 1955 Jan;1(1):20–34. doi: 10.1111/j.1365-2141.1955.tb05484.x. [DOI] [PubMed] [Google Scholar]
- Edson J. R., McArthur J. R., Branda R. F., McCullough J. J., Chou S. N. Successful management of a subdural hematoma in a hemophiliac with an anti-factor VIII antibody. Blood. 1973 Jan;41(1):113–122. [PubMed] [Google Scholar]
- Pole J. R., Barr W., Willoughby M. L. Letter: Continuous-flow exchange-plasmapheresis in severe rhesus isoimmunisation. Lancet. 1974 May 25;1(7865):1051–1051. doi: 10.1016/s0140-6736(74)90446-2. [DOI] [PubMed] [Google Scholar]