Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1977 Sep;30(9):857–861. doi: 10.1136/jcp.30.9.857

Abnormal lipoproteins in multiple myelomatosis.

A Avgerinos, P Skliros, J Pyrovolakis, D Stathakos
PMCID: PMC476575  PMID: 915013

Abstract

In a study of the lipoprotein pattern in multiple myelomatosis electrophoresis on agarose gel showed abnormal lipoproteins, named paralipoproteins (p-Lp), in 24 out of 30 normolipidaemic patients. These paralipoproteins were grouped according to their mobility into one or another of the following types: (1) p-Lp1 with a mobility identical with that of gamma-globulin, (2) p-Lp2 with a mobility between that of beta- and gamma-globulin, (3) p-Lp3 with a mobility identical with that of beta-globulin. On ultracentrifugation the abnormal lipoproteins were found to have a density above 1-063 g/ml.

Full text

PDF
857

Images in this article

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ABEL L. L., LEVY B. B., BRODIE B. B., KENDALL F. E. A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J Biol Chem. 1952 Mar;195(1):357–366. [PubMed] [Google Scholar]
  2. Alexanian R., Bergsagel D. E., Migliore P. J., Vaughn W. K., Howe C. D. Melphalan therapy for plasma cell myeloma. Blood. 1968 Jan;31(1):1–10. [PubMed] [Google Scholar]
  3. Beaumont J. L., Beaumont V., Antonnucci M., Lemort N. Les auto-anticorps antilipoprotéines de myélome. Etude comparée de deux types: l'Iga anti-Lp P.G. et l'IgG anti-Lp A.S. Ann Biol Clin (Paris) 1970;28(5):387–399. [PubMed] [Google Scholar]
  4. Beaumont J. L., Poullin M. F., Jacotot B., Beaumont V. Myélome et hyperlipidémie. IV. Nature de l'activité spécifique antilipoprotéine. Nouv Rev Fr Hematol. 1967 Jul-Aug;7(4):481–498. [PubMed] [Google Scholar]
  5. Carlson K. Lipoprotein fractionation. J Clin Pathol Suppl (Assoc Clin Pathol) 1973;5:32–37. doi: 10.1136/jcp.s1-5.1.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. FOLCH J., LEES M., SLOANE STANLEY G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 May;226(1):497–509. [PubMed] [Google Scholar]
  7. JOVER A. A TECHNIQUE FOR THE DETERMINATION OF SERUM GLYCERIDES. J Lipid Res. 1963 Apr;4:228–230. [PubMed] [Google Scholar]
  8. Koga S., Kozuru M., Hirayama C., Ibayashi H. An unusual lipid-protein complex observed in an IgG myeloma patient. Clin Chim Acta. 1974 Jul 31;54(2):169–176. doi: 10.1016/0009-8981(74)90234-4. [DOI] [PubMed] [Google Scholar]
  9. LENNARD-JONES J. E. Myelomatosis with lipaemia and xanthomata. Br Med J. 1960 Mar 12;1(5175):781–783. doi: 10.1136/bmj.1.5175.781. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LEWIS L. A., PAGE I. H. AN UNUSUAL SERUM LIPOPROTEIN-GLOBULIN COMPLEX IN A PATIENT WITH HYPERLIPEMIA. Am J Med. 1965 Feb;38:286–297. doi: 10.1016/0002-9343(65)90183-x. [DOI] [PubMed] [Google Scholar]
  11. NEUFELD A. H., MORTON H. S., HALPENNY G. W. MYELOMATOSIS WITH XANTHOMATOSIS MULTIFORME. Can Med Assoc J. 1964 Aug 22;91:374–380. [PMC free article] [PubMed] [Google Scholar]
  12. Pagé M., Loiselle J. M., Talbot J. Letter: Lipophilic paraproteins. N Engl J Med. 1974 Aug 29;291(9):475–476. doi: 10.1056/NEJM197408292910919. [DOI] [PubMed] [Google Scholar]
  13. SACHS B. A., CADY P., ROSS G. An abnormal lipid-like material and carbohydrate in the sera of patients with multiple myeloma. Am J Med. 1954 Nov;17(5):662–669. doi: 10.1016/0002-9343(54)90025-x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES