Abstract
In a study of the lipoprotein pattern in multiple myelomatosis electrophoresis on agarose gel showed abnormal lipoproteins, named paralipoproteins (p-Lp), in 24 out of 30 normolipidaemic patients. These paralipoproteins were grouped according to their mobility into one or another of the following types: (1) p-Lp1 with a mobility identical with that of gamma-globulin, (2) p-Lp2 with a mobility between that of beta- and gamma-globulin, (3) p-Lp3 with a mobility identical with that of beta-globulin. On ultracentrifugation the abnormal lipoproteins were found to have a density above 1-063 g/ml.
Full text
PDF




Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- ABEL L. L., LEVY B. B., BRODIE B. B., KENDALL F. E. A simplified method for the estimation of total cholesterol in serum and demonstration of its specificity. J Biol Chem. 1952 Mar;195(1):357–366. [PubMed] [Google Scholar]
- Alexanian R., Bergsagel D. E., Migliore P. J., Vaughn W. K., Howe C. D. Melphalan therapy for plasma cell myeloma. Blood. 1968 Jan;31(1):1–10. [PubMed] [Google Scholar]
- Beaumont J. L., Beaumont V., Antonnucci M., Lemort N. Les auto-anticorps antilipoprotéines de myélome. Etude comparée de deux types: l'Iga anti-Lp P.G. et l'IgG anti-Lp A.S. Ann Biol Clin (Paris) 1970;28(5):387–399. [PubMed] [Google Scholar]
- Beaumont J. L., Poullin M. F., Jacotot B., Beaumont V. Myélome et hyperlipidémie. IV. Nature de l'activité spécifique antilipoprotéine. Nouv Rev Fr Hematol. 1967 Jul-Aug;7(4):481–498. [PubMed] [Google Scholar]
- Carlson K. Lipoprotein fractionation. J Clin Pathol Suppl (Assoc Clin Pathol) 1973;5:32–37. doi: 10.1136/jcp.s1-5.1.32. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FOLCH J., LEES M., SLOANE STANLEY G. H. A simple method for the isolation and purification of total lipides from animal tissues. J Biol Chem. 1957 May;226(1):497–509. [PubMed] [Google Scholar]
- JOVER A. A TECHNIQUE FOR THE DETERMINATION OF SERUM GLYCERIDES. J Lipid Res. 1963 Apr;4:228–230. [PubMed] [Google Scholar]
- Koga S., Kozuru M., Hirayama C., Ibayashi H. An unusual lipid-protein complex observed in an IgG myeloma patient. Clin Chim Acta. 1974 Jul 31;54(2):169–176. doi: 10.1016/0009-8981(74)90234-4. [DOI] [PubMed] [Google Scholar]
- LENNARD-JONES J. E. Myelomatosis with lipaemia and xanthomata. Br Med J. 1960 Mar 12;1(5175):781–783. doi: 10.1136/bmj.1.5175.781. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LEWIS L. A., PAGE I. H. AN UNUSUAL SERUM LIPOPROTEIN-GLOBULIN COMPLEX IN A PATIENT WITH HYPERLIPEMIA. Am J Med. 1965 Feb;38:286–297. doi: 10.1016/0002-9343(65)90183-x. [DOI] [PubMed] [Google Scholar]
- NEUFELD A. H., MORTON H. S., HALPENNY G. W. MYELOMATOSIS WITH XANTHOMATOSIS MULTIFORME. Can Med Assoc J. 1964 Aug 22;91:374–380. [PMC free article] [PubMed] [Google Scholar]
- Pagé M., Loiselle J. M., Talbot J. Letter: Lipophilic paraproteins. N Engl J Med. 1974 Aug 29;291(9):475–476. doi: 10.1056/NEJM197408292910919. [DOI] [PubMed] [Google Scholar]
- SACHS B. A., CADY P., ROSS G. An abnormal lipid-like material and carbohydrate in the sera of patients with multiple myeloma. Am J Med. 1954 Nov;17(5):662–669. doi: 10.1016/0002-9343(54)90025-x. [DOI] [PubMed] [Google Scholar]



