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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1977 Sep;30(9):878–880. doi: 10.1136/jcp.30.9.878

Carcinoembryonic antigen in thyroid disease.

J Economidou, P Karacoulis, O N Manousos, E Manesis, A Kydonakis, D A Koutras
PMCID: PMC476579  PMID: 915016

Abstract

Plasma carcinoembryonic antigen (CEA) levels were measured by the Z-Gel technique in 138 patients with benign thyroidopathies, 25 patients with thyroid cancer, and 141 normal persons. Levels were raised (above 5 ng/ml) in 2% of the normal subjects, in none of the patients with benign thyroidopathies, and in 20% of the patients with thyroid cancer. They were considerably raised in all cases of medullary carcinoma of the thyroid but they were also high in other histological types of thyroid cancer. Measurement of plasma CEA may be of value in the preoperative diagnosis and follow-up of patients with thyroid cancer.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CROOKS J., MURRAY I. P., WAYNE E. J. Statistical methods applied to the clinical diagnosis of thyrotoxicosis. Q J Med. 1959 Apr;28(110):211–234. [PubMed] [Google Scholar]
  2. Dhar P., Moore T., Zamcheck N., Kupchik H. Z. Carcinoembryonic antigen (CEA) in colonic cancer. Use in preoperative and postoperative diagnosis and prognosis. JAMA. 1972 Jul 3;221(1):31–35. [PubMed] [Google Scholar]
  3. GOLD P., FREEDMAN S. O. DEMONSTRATION OF TUMOR-SPECIFIC ANTIGENS IN HUMAN COLONIC CARCINOMATA BY IMMUNOLOGICAL TOLERANCE AND ABSORPTION TECHNIQUES. J Exp Med. 1965 Mar 1;121:439–462. doi: 10.1084/jem.121.3.439. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Isaacson P., Judd M. A. Carcinoembryonic antigen in medullary carcinoma of thyroid. Lancet. 1976 Nov 6;2(7993):1016–1017. doi: 10.1016/s0140-6736(76)90847-3. [DOI] [PubMed] [Google Scholar]
  5. Ishikawa N., Hamada S. Association of medullary carcinoma of the thyroid with carcinoembryonic antigen. Br J Cancer. 1976 Aug;34(2):111–115. doi: 10.1038/bjc.1976.133. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Laurence D. J., Neville A. M. Foetal antigens and their role in the diagnosis and clinical management of human neoplasms: a review. Br J Cancer. 1972 Oct;26(5):335–355. doi: 10.1038/bjc.1972.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Laurence D. J., Stevens U., Bettelheim R., Darcy D., Leese C., Turberville C., Alexander P., Johns E. W., Neville A. M. Role of plasma carcinoembryonic antigen in diagnosis of gastrointestinal, mammary, and bronchial carcinoma. Br Med J. 1972 Sep 9;3(5827):605–609. doi: 10.1136/bmj.3.5827.605. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Lo Gerfo P., Herter F. P., Barker H. G., Bennett S. Immunologic tests for the detection of gastrointestinal cancers. Surg Clin North Am. 1972 Aug;52(4):829–837. doi: 10.1016/s0039-6109(16)39782-1. [DOI] [PubMed] [Google Scholar]
  9. Lo Gerfo P., Krupey J., Hansen H. J. Demonstration of an antigen common to several varieties of neoplasia. N Engl J Med. 1971 Jul 15;285(3):138–141. doi: 10.1056/NEJM197107152850302. [DOI] [PubMed] [Google Scholar]
  10. MALAMOS B. K., DAIKOS G. K., SAMARA V., KOUTRAS D. A. The use of radioiodine for the diagnosis and treatment of thyroid diseases. Acta Endocrinol (Copenh) 1959 Nov;32:311–329. doi: 10.1530/acta.0.xxxii0311. [DOI] [PubMed] [Google Scholar]
  11. Mach J. P., Jaeger P., Bertholet M. M., Ruegsegger C. H., Loosli R. M., Pettavel J. Detection of recurrence of large-bowel carcinoma by radioimmunoassay of circulating carcinoembryonic antigen (C.E.A.). Lancet. 1974 Sep 7;2(7880):535–540. doi: 10.1016/s0140-6736(74)91872-8. [DOI] [PubMed] [Google Scholar]
  12. Papachristou D., Terz J. J., Lawrence W., Jr Clinical evaluation of the assay for carcinoembryonic antigen (CEA). Va Med Mon (1918) 1974 Feb;101(2):108–113. [PubMed] [Google Scholar]
  13. Reynoso G., Chu T. M., Holyoke D., Cohen E., Nemoto T., Wang J. J., Chuang J., Guinan P., Murphy G. P. Carcinoembryonic antigen in patients with different cancers. JAMA. 1972 Apr 17;220(3):361–365. [PubMed] [Google Scholar]
  14. Rochman H., deGroot L. J., Rieger C. H., Varnavides L. A., Refetoff S., Joung J. I., Hoye K. Carcinoembryonic antigen and humoral antibody response in patients with thyroid carcinoma. Cancer Res. 1975 Oct;35(10):2689–2692. [PubMed] [Google Scholar]
  15. Thomson D. M., Krupey J., Freedman S. O., Gold P. The radioimmunoassay of circulating carcinoembryonic antigen of the human digestive system. Proc Natl Acad Sci U S A. 1969 Sep;64(1):161–167. doi: 10.1073/pnas.64.1.161. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Williams C. R., Brewer D. B. Medullary carcinoma of the thyroid. Br J Surg. 1969 Jun;56(6):437–443. doi: 10.1002/bjs.1800560610. [DOI] [PubMed] [Google Scholar]

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