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. 1977 Oct;30(10):914–924. doi: 10.1136/jcp.30.10.914

IgA localisation in glomerular diseases.

W Lawler, G Williams, P Tarpey, E J Acheson, N P Mallick
PMCID: PMC476594  PMID: 338632

Abstract

The structural changes found on light and electron microscopy study of 25 renal biopsy specimens that showed significant glomerular IgA deposition on immunofluorescence were correlated with relevant clinical data. The morphology of a wide range of glomerulopathies seeen included mesangial proliferative (60%), membranous (12%), rapidly progressive proliferative (8%), mesangio-capillary (8%), and no light microscope change (8%). Four of the 15 cases (60%) of mesangial proliferative glomerulonephritis were associated with focal segmental sclerosis and 10 with focal segmental and focal global sclerosis. In addition, 7 of the 15 cases showed capsular crescents. The clinicopathological correlations indicated that the prognosis in this group is unfavourable when focal global sclerosis and capsular crescents are present, particularly when both occur in the same biopsy specimen.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. André F., André C. Letter: Cirrhotic glomerulonephritis and secretory immunoglobulin A. Lancet. 1976 Jan 24;1(7952):197–197. doi: 10.1016/s0140-6736(76)91304-0. [DOI] [PubMed] [Google Scholar]
  2. Berger J. IgA glomerular deposits in renal disease. Transplant Proc. 1969 Dec;1(4):939–944. [PubMed] [Google Scholar]
  3. Berger J., Yaneva H., Hinglais N. Immunohistochemistry of glomerulonephritis. Adv Nephrol Necker Hosp. 1971;1:11–30. [PubMed] [Google Scholar]
  4. Callard P., Feldmann G., Prandi D., Belair M. F., Mandet C., Weiss Y., Druet P., Benhamou J. P., Bariety J. Immune complex type glomerulonephritis in cirrhosis of the liver. Am J Pathol. 1975 Aug;80(2):329–340. [PMC free article] [PubMed] [Google Scholar]
  5. Crumb C. K. Renal involvement in Schönlein-Henoch syndrome. Perspect Nephrol Hypertens. 1976;3:43–55. [PubMed] [Google Scholar]
  6. Davies D. R., Tighe J. R., Jones N. F., Brown G. W. Recurrent haematuria and mesangial IgA deposition. J Clin Pathol. 1973 Sep;26(9):672–677. doi: 10.1136/jcp.26.9.672. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Davis B. K., Cavallo T. Membranoproliferative glomerulonephritis. Localization of early components of complement in glomerular deposits. Am J Pathol. 1976 Aug;84(2):283–298. [PMC free article] [PubMed] [Google Scholar]
  8. Dobrin R. S., Knudson F. E., Michael A. F. The secretory immune system and renal disease. Clin Exp Immunol. 1975 Aug;21(2):318–328. [PMC free article] [PubMed] [Google Scholar]
  9. Evans D. J., Williams D. G., Peters D. K., Sissons J. G., Boulton-Jones J. M., Ogg C. S., Cameron J. S., Hoffbrand B. I. Glomerular deposition of properdin in Henoch-Schönlein syndrome and idiopathic focal nephritis. Br Med J. 1973 Aug 11;3(5875):326–328. doi: 10.1136/bmj.3.5875.326. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Germuth F. G., Jr, Rodriguez E. Focal mesangiopathic glomerulonephritis: prevalence and pathogenesis. Kidney Int. 1975 Apr;7(4):216–223. doi: 10.1038/ki.1975.33. [DOI] [PubMed] [Google Scholar]
  11. Hyman L. R., Wagnild J. P., Beirne G. J., Burkholder P. M. Immunoglobulin-A distribution in glomerular disease. Analysis of immunofluorescence localization and pathogenetic significance. Kidney Int. 1973 Jun;3(6):397–408. doi: 10.1038/ki.1973.62. [DOI] [PubMed] [Google Scholar]
  12. Kupor L. R., Mullins J. D., McPhaul J. J., Jr Immunopathologic findings in idiopathic renal hematuria. Arch Intern Med. 1975 Sep;135(9):1204–1211. [PubMed] [Google Scholar]
  13. Lawler W., Tarpey P., Williams G., Acheson E. J., Mallick N. P. Diseases and histological normality of the renal glomerulus: a clinicopathological study. J Clin Pathol. 1976 May;29(5):380–397. doi: 10.1136/jcp.29.5.380. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Levy M., Beaufils H., Gubler M. C., Habib R. Idiopathic recurrent macroscopic hematuria and mesangial IgA-IgG deposits in children (Berger's disease). Clin Nephrol. 1972 Mar-Apr;1(2):63–69. [PubMed] [Google Scholar]
  15. Lowance D. C., Mullins J. D., McPhaul J. J., Jr Immunoglobulin A (IgA) associated glomerulonephritis. Kidney Int. 1973 Mar;3(3):167–176. doi: 10.1038/ki.1973.25. [DOI] [PubMed] [Google Scholar]
  16. McCluskey R. T. Evidence for immunologic mechanisms in several forms of human glomerular diseases. Bull N Y Acad Med. 1970 Oct;46(10):769–788. [PMC free article] [PubMed] [Google Scholar]
  17. McCoy R. C., Abramowsky C. R., Tisher C. C. IgA nephropathy. Am J Pathol. 1974 Jul;76(1):123–144. [PMC free article] [PubMed] [Google Scholar]
  18. Rothfield N., Ross H. A., Minta J. O., Lepow I. H. Glomerular and dermal depostion of properdin in systemic lupus erythematosus. N Engl J Med. 1972 Oct 5;287(14):681–685. doi: 10.1056/NEJM197210052871402. [DOI] [PubMed] [Google Scholar]
  19. Roy L. P., Fish A. J., Vernier R. L., Michael A. F. Recurrent macroscopic hematuria, focal nephritis, and mesangial deposition of immunoglobulin and complement. J Pediatr. 1973 May;82(5):767–772. doi: 10.1016/s0022-3476(73)80064-2. [DOI] [PubMed] [Google Scholar]
  20. SAKAGUCHI H., DACHS S., GRISHMAN E., PARONETTO F., SALOMON M., CHURG J. HEPATIC GLOMERULOSCLEROSIS. AN ELECTRON MICROSCOPIC STUDY OF RENAL BIOPSIES IN LIVER DISEASES. Lab Invest. 1965 May;14:533–545. [PubMed] [Google Scholar]
  21. SALOMON M. I., SAKAGUCHI H., CHURG J., DACHS S., GRISHMAN E., MAUTNER W., PARONETTO F., ROSENTHAL W. S. RENAL LESIONS IN HEPATIC DISEASE: A STUDY BASED ON KIDNEY BIOPSIES. Arch Intern Med. 1965 Jun;115:704–709. doi: 10.1001/archinte.1960.03860180076013. [DOI] [PubMed] [Google Scholar]
  22. Sissons J. G., Woodrow D. F., Curtis J. R., Evans D. J., Gower P. E., Sloper J. C., Peters D. K. Isolated glomerulonephritis with mesangial IgA deposits. Br Med J. 1975 Sep 13;3(5984):611–614. doi: 10.1136/bmj.3.5984.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Svec K. H., Blair J. D., Kaplan M. H. Immunopathologic studies of systemic lupus erythematosus (SLE). I. Tissue-bound immunoglobulins in relation to serum antinuclear immunoglobulins in systemic lupus and in chronic liver disease with LE cell factor. J Clin Invest. 1967 Apr;46(4):558–568. doi: 10.1172/JCI105557. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. Tighe J. R. The mesangium in glomerular disease. Proc R Soc Med. 1975 Mar;68(3):151–158. doi: 10.1177/003591577506800305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  25. Travis L. B., Street L., Smith E., Chipps B. Renal involvement in systemic diseases in childhood. Perspect Nephrol Hypertens. 1976;3:275–295. [PubMed] [Google Scholar]
  26. Urizar R. E., Michael A., Sisson S., Vernier R. L. Anaphylactoid purpura. II. Immunofluorescent and electron microscopic studies of the glomerular lesions. Lab Invest. 1968 Oct;19(4):437–450. [PubMed] [Google Scholar]
  27. Vernier R. L., Resnick J. S., Mauer S. M. Recurrent hematuria and focal glomerulonephritis. Kidney Int. 1975 Apr;7(4):224–231. doi: 10.1038/ki.1975.34. [DOI] [PubMed] [Google Scholar]
  28. Whitworth J. A., Leibowitz S., Kennedy M. C., Cameron J. S., Chantler C. IgA and glomerular disease. Clin Nephrol. 1976 Jan;5(1):33–36. [PubMed] [Google Scholar]
  29. Woodroffe A. J., Thomson N. M., Meadows R., Lawrence J. R. IgA-associated glomerulonephritis. Aust N Z J Med. 1975 Apr;5(2):97–100. doi: 10.1111/j.1445-5994.1975.tb03635.x. [DOI] [PubMed] [Google Scholar]
  30. Zimmerman S. W., Burkholder P. M. Immunoglobulin A nephropathy. Arch Intern Med. 1975 Sep;135(9):1217–1223. [PubMed] [Google Scholar]
  31. van de Putte L. B., de la Riviere G. B., van Breda Vriesman P. J. Recurrent or persistent hematuria. Sign of mesangial immune-complex deposition. N Engl J Med. 1974 May 23;290(21):1165–1170. doi: 10.1056/NEJM197405232902104. [DOI] [PubMed] [Google Scholar]

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