Table 4. Risk of Major Vascular Event Unadjusted and Adjusted by Potential Confounders.
| Model 1 | Model 2 | Model 3 | Model 4 | |||||
|---|---|---|---|---|---|---|---|---|
| HR (95%) | p | HR (95%) | p | HR (95%) | p | HR (95%) | p | |
| IL6 continuous (per SD=11.98) | 1.1 (1.0, 1.2) | 0.01 | 1.1 (1.0, 1.2) | 0.003 | 1.1 (1.0, 1.2) | 0.008 | 1.1 (1.0, 1.2) | 0.017 |
| IL6 | 0.23 | 0.21 | 0.33 | 0.32 | ||||
| Quartile 1 (Referent) | -- | -- | -- | -- | ||||
| Quartile 2 | 1.23[0.72,2.08] | 0.79[0.43,1.46] | 0.81[0.43,1.50] | 0.82[0.44,1.53] | ||||
| Quartile 3 | 1.03[0.60,1.78] | 1.37[0.80,2.37] | 1.32[0.75,2.31] | 1.33[0.76,2.33] | ||||
| Quartile 4 | 0.88[0.50,1.57] | 1.32[0.76,2.30] | 1.27[0.72,2.27] | 1.32[0.74,2.34] | ||||
| MCP1 continuous (per SD=127.93) | 1.1 (0.89, 1.3) | 0.42 | 1.1 (0.92, 1.4) | 0.23 | 1.1 (0.88, 1.4) | 0.64 | 1.1 (0.89 1.3) | 0.79 |
| MCP1 | 0.347 | 0.56 | 0.55 | 0.47 | ||||
| Quartile 1 (Referent) | -- | -- | -- | -- | ||||
| Quartile 2 | 0.71[0.37,1.36] | 0.77 [0.39,1.52] | 0.72[0.36,1.45] | 0.73 [0.36,1.48] | ||||
| Quartile 3 | 0.84[0.45,1.57] | 0.91 [0.47,1.77] | 0.87[0.44,1.70] | 0.92[0.47,1.82] | ||||
| Quartile 4 | 1.16[0.65,2.07] | 1.22 [0.66,2.27] | 1.16[0.62,2.18] | 1.25[0.67,2.37] | ||||
| SAA continuous (per SD=22.6) | 1.1 (0.95, 1.2) | 0.27 | 1.1 (0.95, 1.2) | 0.26 | 1.1 (0.95 1.2) | 0.27 | 1.1 (0.96, 1.2) | 0.19 |
| SAA | 0.34 | 0.31 | 0.20 | 0.19 | ||||
| Quartile 1 (Referent) | -- | -- | -- | -- | ||||
| Quartile 2 | 0.70[0.39,1.23] | 0.70 [0.40,1.25] | 0.64[0.351.14] | 0.63 [0.35,1.13] | ||||
| Quartile 3 | 0.78[0.45,1.36] | 0.78 [0.45,1.37] | 0.76[0.43,1.35] | 0.75[0.42,1.33] | ||||
| Quartile 4 | 1.10[0.67,1.83] | 1.14 [0.68,1.92] | 1.12[0.66,1.90] | 1.11[0.66,1.89] | ||||
| TNFR1 continuous (per SD=1.46) | 1.2 (1.1 1.4) | 0.002 | 1.2 (1.1, 1.4) | 0.003 | 1.2 (1.0, 1.4) | 0.017 | 1.2 (1.0, 1.4) | 0.01 |
| TNFR | 0.02 | 0.02 | 0.06 | 0.05 | ||||
| Quartile 1 (Referent) | -- | -- | -- | -- | ||||
| Quartile 2 | 0.92[0.47,1.78] | 0.89 [0.46,1.72] | 0.78[0.39,1.54] | 0.78 [0.39,1.55] | ||||
| Quartile 3 | 1.66[0.93,2.97] | 1.59 [0.89,2.86] | 1.50[0.83,2.70] | 1.55[0.86, 2.80] | ||||
| Quartile 4 | 1.99[1.13,3.51] | 1.98 [1.11,3.52] | 1.66[0.92,2.99] | 1.68[0.93,3.04] | ||||
| CD40L continuous (per SD=4.39) | 0.99 (0.81, 1.2) | 0.93 | 1.0 (0.85, 1.3) | 0.67 | 1.0 (0.81, 1.3) | 0.94 | 0.99 (0.80, 1.2) | 0.99 |
| CD40L | 0.70 | 0.88 | 0.65 | 0.62 | ||||
| Quartile 1 (Referent) | -- | -- | -- | -- | ||||
| Quartile 2 | 1.23[0.72,2.08] | 1.20[0.70,2.04] | 1.31[0.76,2.25] | 1.29[0.75,2.22] | ||||
| Quartile 3 | 1.03[0.60,1.78] | 1.07[0.61,1.86] | 1.09[0.62,1.92] | 1.12[0.63,1.97] | ||||
| Quartile 4 | 0.88[0.50,1.57] | 0.97[0.53,1.76] | 0.91[0.49,1.70] | 0.88[0.47,1.63] | ||||
- Unadjusted
- Adjusted for Demographics (Age, Sex, Race, Region)
- Adjusted for Demographics (Age, Sex, Race, Region) and Co-morbidities (Hypertension, Smoking, History of Prior Ischemic Stroke, Diabetes, LDL and HDL)
- Adjusted for Demographics (Age, Sex, Race, Region) Co-morbidities (Hypertension, Smoking, History of Prior Ischemic Stroke, Diabetes, Low Density Lipoprotein and High Density Lipoprotein) and Statin use at baseline