Abstract
The 14C-aminopyrine breath test was used to measure liver function in 14 normal subjects, 16 patients with alcoholic cirrhosis, 14 alcoholics without cirrhosis, and 29 patients taking a variety of drugs. The normal value for the breath test was 8.6 +/- 1.5%, whereas it was significantly lower (5.1 +/- 3.8%) in patients with alcoholic cirrhosis. Higher than normal values were found in some alcoholic patients without cirrhosis and in patients receiving enzyme-inducing drugs, such as phenobarbitone. There was a significant correlation between serum gamma-glutamyltransferase and breath test in these groups. Some patients with alcoholic cirrhosis may also be capable of enzyme induction.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Bircher J., Küpfer A., Gikalov I., Preisig R. Aminopyrine demethylation measured by breath analysis in cirrhosis. Clin Pharmacol Ther. 1976 Oct;20(4):484–492. doi: 10.1002/cpt1976204484. [DOI] [PubMed] [Google Scholar]
- Brohult J., Sundblad L. Isoenzyme patterns of serum alkaline phosphatase in ethanol-induced liver injury. Acta Med Scand. 1973 Dec;194(6):497–499. doi: 10.1111/j.0954-6820.1973.tb19480.x. [DOI] [PubMed] [Google Scholar]
- Ceriotti G. A new look at the measurement and interpretation of enzyme assays. Ann Clin Biochem. 1976 Mar;13(2):345–353. doi: 10.1177/000456327601300115. [DOI] [PubMed] [Google Scholar]
- Hepner G. W., Vesell E. S. Assessment of aminopyrine metabolism in man by breath analysis after oral administration of 14C-aminopyrine. Effects of phenobarbital, disulfiram and portal cirrhosis. N Engl J Med. 1974 Dec 26;291(26):1384–1388. doi: 10.1056/NEJM197412262912605. [DOI] [PubMed] [Google Scholar]
- Hepner G. W., Vesell E. S. Quantitative assessment of hepatic function by breath analysis after oral administration of (14C)aminopyrine. Ann Intern Med. 1975 Nov;83(5):632–638. doi: 10.7326/0003-4819-83-5-632. [DOI] [PubMed] [Google Scholar]
- Lauterburg B. H., Bircher J. Expiratory measurement of maximal amino-pyrine demethylation in vivo: effect of phenobarbital, partial hepatectomy, protacaval shunt and bile duct ligation in the rat. J Pharmacol Exp Ther. 1976 Feb;196(2):501–509. [PubMed] [Google Scholar]
- Levi A. J., Sherlock S., Walker D. Phenylbutazone and isoniazid metabolism in patients with liver disease in relation to previous drug therapy. Lancet. 1968 Jun 15;1(7555):1275–1279. doi: 10.1016/s0140-6736(68)92292-7. [DOI] [PubMed] [Google Scholar]
- Lieber C. S. Liver adaptation and injury in alcoholism. N Engl J Med. 1973 Feb 15;288(7):356–362. doi: 10.1056/NEJM197302152880710. [DOI] [PubMed] [Google Scholar]
- Misra P. S., Lefévre A., Ishii H., Rubin E., Lieber C. S. Increase of ethanol, meprobamate and pentobarbital metabolism after chronic ethanol administration in man and in rats. Am J Med. 1971 Sep;51(3):346–351. doi: 10.1016/0002-9343(71)90270-1. [DOI] [PubMed] [Google Scholar]
- Rosalki S. B. Gamma-glutamyl transpeptidase. Adv Clin Chem. 1975;17:53–107. doi: 10.1016/s0065-2423(08)60248-6. [DOI] [PubMed] [Google Scholar]
- Rosalki S. B., Rau D. Serum -glutamyl transpeptidase activity in alcoholism. Clin Chim Acta. 1972 Jun;39(1):41–47. doi: 10.1016/0009-8981(72)90297-5. [DOI] [PubMed] [Google Scholar]
- Winchell H. S., Stahelin H., Kusubov N., Slanger B., Fish M., Pollycove M., Lawrence J. H. Kinetics of CO2-HCO3 minus in normal adult males. J Nucl Med. 1970 Dec;11(12):711–715. [PubMed] [Google Scholar]