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. 1970 May;23(4):296–298. doi: 10.1136/jcp.23.4.296

Macrocytosis in Down's syndrome and during long-term anticonvulsant therapy

R D Eastham 1,2, J Jancar 1,2
PMCID: PMC476746  PMID: 4246925

Abstract

In a group of non-anaemic mentally retarded patients a significant increase in mean red cell volume has been demonstrated in epileptic patients being treated with anticonvulsants. The possible sites of interference of anticonvulsants with folate activity in the body, and problems associated with folic acid supplements during anticonvulsant therapy, are discussed.

During the survey it was confirmed that the mean red cell volume is abnormally increased in many cases of Down's syndrome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. CHANARIN I., MOLLIN D. L., ANDERSON B. B. Folic acid deficiency and the megaloblastic anaemias. Proc R Soc Med. 1958 Sep;51(9):757–763. doi: 10.1177/003591575805100916. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. DRUSKIN M. S., WALLEN M. H., BONAGURA L. Anticonvulsant-associated megaloblastic anemia. Response to 25 microgm. of folic acid administered by mouth daily. N Engl J Med. 1962 Sep 6;267:483–485. doi: 10.1056/NEJM196209062671004. [DOI] [PubMed] [Google Scholar]
  3. Dahlke M. B., Mertens-Roesler E. Malabsorption of folic acid due to diphenylhydantoin. Blood. 1967 Sep;30(3):341–351. [PubMed] [Google Scholar]
  4. Eastham R. D., Jancar J. Macrocytosis in Down's syndrome. Lancet. 1969 Apr 26;1(7600):895–895. doi: 10.1016/s0140-6736(69)91949-7. [DOI] [PubMed] [Google Scholar]
  5. GIRDWOOD R. H., LENMAN J. A. Megaloblastic anaemia occurring during primidone therapy. Br Med J. 1956 Jan 21;1(4959):146–147. doi: 10.1136/bmj.1.4959.146. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HAWKINS C. F., MEYNELL M. J. Macrocytosis and macrocytic anaemia caused by anticonvulsant drugs. Q J Med. 1958 Jan;27(105):45–63. [PubMed] [Google Scholar]
  7. HERBERT V. STUDIES OF FOLATE DEFICIENCY IN MAN. Proc R Soc Med. 1964 May;57:377–384. doi: 10.1177/003591576405700516. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. HERBERT V., ZALUSKY R. Interrelations of vitamin B12 and folic acid metabolism: folic acid clearance studies. J Clin Invest. 1962 Jun;41:1263–1276. doi: 10.1172/JCI104589. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Ibbotson R. N., Dilena B. A., Horwood J. M. Studies on deficiency and absorption of folates in patients on anticonvulsant drugs. Australas Ann Med. 1967 May;16(2):144–150. doi: 10.1111/imj.1967.16.2.144. [DOI] [PubMed] [Google Scholar]
  10. KLIPSTEIN F. A. SUBNORMAL SERUM FOLATE AND MACROCYTOSIS ASSOCIATED WITH ANTICONVULSANT DRUG THERAPY. Blood. 1964 Jan;23:68–86. [PubMed] [Google Scholar]
  11. Malpas J. S., Spray G. H., Witts L. J. Serum folic-acid and vitamin-B12 levels in anticonvulsant therapy. Br Med J. 1966 Apr 16;1(5493):955–957. doi: 10.1136/bmj.1.5493.955. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Miller D. R. Serum folate deficiency in children receiving anticonvulsant therapy. Pediatrics. 1968 Mar;41(3):630–635. [PubMed] [Google Scholar]
  13. Naiman J. L., Oski F. A., Mellman W. J. Phosphokinase activity of erythrocytes in mongolism. Lancet. 1965 Apr 10;1(7389):821–821. doi: 10.1016/s0140-6736(65)92994-6. [DOI] [PubMed] [Google Scholar]
  14. Reynolds E. H. Effects of folic acid on the mental state and fit-frequency of drug-treated epileptic patients. Lancet. 1967 May 20;1(7499):1086–1088. doi: 10.1016/s0140-6736(67)92654-2. [DOI] [PubMed] [Google Scholar]

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