Table 2. Expression of the CD158a/b/e killer-immunoglobulin-like receptors (KIR) and the CD94 and CD161 C-type lectin-like receptors on peripheral blood CD56low NK cells from patients with clonal (n = 9) and polyclonal (n = 12*) expansions of CD56low NK cells.
Percentage of CD56low NK cells expressing each marker | |||||
---|---|---|---|---|---|
CD158a | CD158b | CD158e | CD94 | CD161 | |
Clonal#1 | 20 | 58 | 6 | 100 | 40 |
Clonal#2 | 8 | 10 | 8 | 100 | 100 |
Clonal#3 | 39 | 20 | 46 | 100 | 87 |
Clonal#4 | 0 | 1 | 1 | 100 | 0 |
Clonal#5 | 0 | 1 | 1 | 100 | 5 |
Clonal#6 | 0 | 3 | 2 | 100 | 0 |
Clonal#7 | 1 | 2 | 2 | 100 | 2 |
Clonal#8 | 0 | 0 | 0 | 100 | 0 |
Clonal#9 | 0 | 7 | 0 | 100 | 100 |
Median | 0 | 3 | 2 | 100 | 5 |
Interquartile range | 0–14 | 1–15 | 0.5–7 | 100–100 | 0–93 |
Minimum-maximum values | 0–39 | 0–58 | 0–46 | 100–100 | 0–100 |
Polyclonal#1 | 73 | 23 | 9 | 100 | 57 |
Polyclonal#2 | 10 | 10 | 0 | 81 | 35 |
Polyclonal#5 | 14 | n.a. | 9 | 47 | 32 |
Polyclonal#6 | 27 | 28 | 20 | 42 | 25 |
Polyclonal#7 | 28 | 15 | 11 | 40 | 78 |
Polyclonal#8 | 46 | 37 | 26 | 34 | 75 |
Polyclonal#9 | 3 | 43 | 0 | 56 | n.a. |
Polyclonal#10 | 75 | 15 | 6 | 65 | 61 |
Polyclonal#11 | 58 | 73 | 0 | 75 | 62 |
Polyclonal#12 | 6 | 76 | 0 | 80 | 20 |
Polyclonal#13 | 3 | 60 | 18 | 76 | 77 |
Polyclonal#14 | 29 | 70 | 0 | 72 | 37 |
Median | 27.5 | 37 | 7.5 | 68.5 | 57 |
Interquartile range | 7–55 | 15–70 | 0–16.3 | 43.3–79 | 32–75 |
Minimum-maximum values | 3–75 | 23–76 | 0–26 | 34–100 | 25–78 |
p-values | 0.007 | 0.003 | n.s. | <0.0001 | n.s. |
n.a.: not available; n.s.: Not statistically significant differences (p > 0.05) between clonal and polyclonal cases.
In two out of the 14 cases with expanded polyclonal CD56low NK cells, data about more than one killer receptor was not available, and therefore, these two cases were excluded from Table 2.