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. 1970 Jul;23(5):379–391. doi: 10.1136/jcp.23.5.379

Megaloblastic anaemia of pregnancy: a clinical and laboratory study with particular reference to the total and labile serum folate levels

P G Rae 1,2,1, P M Robb 1,2
PMCID: PMC476777  PMID: 5476865

Abstract

It has been shown that the incidence of megaloblastic anaemia in a group of 463 randomly selected pregnant women receiving iron was 12 times as high as in a control group of 235 pregnant women receiving iron and folic acid. The incidence of all types of anaemia in the women receiving iron alone was more than three times the incidence in those having iron and folic acid. Some women who were not anaemic or who had normoblastic anaemia had serum folate levels in the same range as the women with megaloblastic anaemia, but none of the women with megaloblastic anaemia had high serum folate levels. The labile fraction of the serum folate was no more reliable than the total serum folate as a diagnostic criterion of megaloblastic erythropoiesis in the individual case. The blood group distribution in the women with megaloblastic anaemia was the same as in the general population. Babies born to mothers with megaloblastic anaemia tended to be smaller than the rest, although there was no difference in the placental weights.

The significance of these findings is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BALL E. W., GILES C. FOLIC ACID AND VITAMIN B12 LEVELS IN PREGNANCY AND THEIR RELATION TO MEGALOBLASTIC ANAEMIA. J Clin Pathol. 1964 Mar;17:165–174. doi: 10.1136/jcp.17.2.165. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cowan J. D., Haffbrand A. V., Mollin D. L. Effect of serum-factors other than folate on the Lactobacillus casei assay. Lancet. 1966 Jan 1;1(7427):11–14. doi: 10.1016/s0140-6736(66)90004-3. [DOI] [PubMed] [Google Scholar]
  3. GATENBY P. B., LILLIE E. W. Clinical analysis of 100 cases of severe megaloblastic anaemia of pregnancy. Br Med J. 1960 Oct 15;2(5206):1111–1114. doi: 10.1136/bmj.2.5206.1111. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. GILES C. Blood-group distribution in megaloblastic anaemia of pregnancy. Lancet. 1960 Nov 12;2(7159):1063–1064. doi: 10.1016/s0140-6736(60)92134-6. [DOI] [PubMed] [Google Scholar]
  5. Giles C. An account of 335 cases of megaloblastic anaemia of pregnancy and the puerperium. J Clin Pathol. 1966 Jan;19(1):1–11. doi: 10.1136/jcp.19.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. HIBBARD B. M., HIBBARD E. D. AETIOLOGICAL FACTORS IN ABRUPTIO PLACENTAE. Br Med J. 1963 Dec 7;2(5370):1430–1436. doi: 10.1136/bmj.2.5370.1430. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. MACKENZIE A., ABBOTT J. Megaloblastic erythropoiesis in pregnancy. Br Med J. 1960 Oct 15;2(5206):1114–1116. doi: 10.1136/bmj.2.5206.1114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. MARTIN R. H., HARPER T. A., KELSO W. SERUM-FOLIC-ACID IN RECURRENT ABORTIONS. Lancet. 1965 Mar 27;1(7387):670–672. doi: 10.1016/s0140-6736(65)91826-x. [DOI] [PubMed] [Google Scholar]
  9. SPRAY G. H. MICROBIOLOGICAL ASSAY OF FOLIC ACID ACTIVITY IN HUMAN SERUM. J Clin Pathol. 1964 Nov;17:660–665. doi: 10.1136/jcp.17.6.660. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Temperley I. J., Meehan M. J., Gatenby P. B. Serum folic acid levels in pregnancy and their relationship to megaloblastic marrow change. Br J Haematol. 1968 Jan;14(1):13–19. doi: 10.1111/j.1365-2141.1968.tb01468.x. [DOI] [PubMed] [Google Scholar]

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