Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1970 Jul;23(5):402–406. doi: 10.1136/jcp.23.5.402

Relationships between platelet function tests in normal and uraemic subjects

A A Hassanein 1, G P McNicol 1, A S Douglas 1
PMCID: PMC476780  PMID: 5476867

Abstract

In tests of platelet function in normal subjects, the following relationships were found: the greater the platelet adhesiveness the less the ability to disaggregate after challenge with adenosine diphosphate (ADP), and the greater the disaggregation after ADP, the longer the clotting time in the test for platelet factor 3 availability. Such correlations were disturbed in uraemic patients.

Full text

PDF
402

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BORN G. V., CROSS M. J. THE AGGREGATION OF BLOOD PLATELETS. J Physiol. 1963 Aug;168:178–195. doi: 10.1113/jphysiol.1963.sp007185. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. FERGUSON J. H., LEWIS J. H., ZUCKER M. B. Bleeding tendency in uremia. Blood. 1956 Dec;11(12):1073–1076. [PubMed] [Google Scholar]
  3. GAARDER A., JONSEN J., LALAND S., HELLEM A., OWREN P. A. Adenosine diphosphate in red cells as a factor in the adhesiveness of human blood platelets. Nature. 1961 Nov 11;192:531–532. doi: 10.1038/192531a0. [DOI] [PubMed] [Google Scholar]
  4. HARDISTY R. M., HUTTON R. A. THE KAOLIN CLOTTING TIME OF PLATELET-RICH PLASMA: A TEST OF PLATELET FACTOR-3 AVAILABILITY. Br J Haematol. 1965 May;11:258–268. doi: 10.1111/j.1365-2141.1965.tb06586.x. [DOI] [PubMed] [Google Scholar]
  5. HELLEM A., OWREN P. A. THE MECHANISM OF THE HEMOSTATIC FUNCTION OF BLOOD PLATELETS. Acta Haematol. 1964 Apr;31:230–238. doi: 10.1159/000209632. [DOI] [PubMed] [Google Scholar]
  6. Hardisty R. M., Hutton R. A. Platelet aggregation and the availability of platelet factor 3. Br J Haematol. 1966 Nov;12(6):764–776. doi: 10.1111/j.1365-2141.1966.tb00164.x. [DOI] [PubMed] [Google Scholar]
  7. Hirsh J., McBride J. A., Dacie J. V. Thrombo-embolism and increased platelet adhesiveness in post-splenectomy thrombocytosis. Australas Ann Med. 1966 May;15(2):122–128. doi: 10.1111/imj.1966.15.2.122. [DOI] [PubMed] [Google Scholar]
  8. Horowitz H. I., Papayoanou M. F. Activation of platelet factor 3 by adenosine 5'diphosphate. Thromb Diath Haemorrh. 1968 Mar 31;19(1):18–28. [PubMed] [Google Scholar]
  9. RATH C. E., MAILLIARD J. A., SCHREINER G. E. Bleeding tendency in uremia. N Engl J Med. 1957 Oct 24;257(17):808–811. doi: 10.1056/NEJM195710242571704. [DOI] [PubMed] [Google Scholar]
  10. SALZMAN E. W. MEASUREMENT OF PLATELET ADHESIVENESS. A SIMPLE IN VITRO TECHNIQUE DEMONSTRATING AN ABNORMALITY IN VON WILLEBRAND'S DISEASE. J Lab Clin Med. 1963 Nov;62:724–735. [PubMed] [Google Scholar]
  11. SPAET T. H., CINTRON J. STUDIES ON PLATELET FACTOR-3 AVAILABILITY. Br J Haematol. 1965 May;11:269–275. doi: 10.1111/j.1365-2141.1965.tb06587.x. [DOI] [PubMed] [Google Scholar]
  12. Salzman E. W., Chambers D. A., Neri L. L. Possible mechanism of aggregation of blood platelets by adenosine diphosphate. Nature. 1966 Apr 9;210(5032):167–169. doi: 10.1038/210167a0. [DOI] [PubMed] [Google Scholar]
  13. Stewart J. H., Castaldi P. A. Uraemic bleeding: a reversible platelet defect corrected by dialysis. Q J Med. 1967 Jul;36(143):409–423. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES