Skip to main content
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1970 Jul;23(5):407–410. doi: 10.1136/jcp.23.5.407

The irrelevance of adhesive platelet estimations after thrombosis

R D Eastham 1
PMCID: PMC476781  PMID: 5529253

Abstract

It has been found that adhesive platelet counts are not of clinical use either after surgical operation or during long-term anticoagulant therapy in the detection of thrombosis. Calculation of the theoretical risk of development of platelet thrombi related to the platelet count suggests a possible reason for this absence of clinical significance. The evidence that platelet adhesiveness alters because of uncontrollable platelet variables and is controlled at least in part by plasma factors is discussed. The possibility of measuring the plasma factors is considered briefly.

Full text

PDF
407

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bennett P. N. Role of erythrocytes in the acute platelet response to operation. J Clin Pathol. 1968 Nov;21(6):695–697. doi: 10.1136/jcp.21.6.695. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Besterman E., Myat G., Travadi V. Diurnal variations of platelet stickiness compared with effects produced by adrenaline. Br Med J. 1967 Mar 11;1(5540):597–600. doi: 10.1136/bmj.1.5540.597. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Bolton C. H., Hampton J. R., Mitchell J. R. Nature of the transferable factor which causes abnormal platelet behaviour in vascular disease. Lancet. 1967 Nov 25;2(7526):1101–1105. doi: 10.1016/s0140-6736(67)90614-9. [DOI] [PubMed] [Google Scholar]
  4. Born G. V. Uptake of adenosine and of adenosine diphosphate by human blood platelets. Nature. 1965 Jun 12;206(989):1121–1122. doi: 10.1038/2061121a0. [DOI] [PubMed] [Google Scholar]
  5. Davies D. F., Lloyd V. Relationship between platelet adhesiveness and plasma surface activity in coronary heart disease. Cardiovasc Res. 1967 Apr;1(2):108–110. doi: 10.1093/cvr/1.2.108. [DOI] [PubMed] [Google Scholar]
  6. Dawber J. G., Roberts J. C. An electrical double layer theory for platelet adhesiveness and initiation of intravascular thrombosis. Thromb Diath Haemorrh. 1968 Jul 31;19(3):451–458. [PubMed] [Google Scholar]
  7. EASTHAM R. D. RAPID ADHESIVE PLATELET COUNT IN WHOLE BLOOD. J Clin Pathol. 1964 Jan;17:45–46. doi: 10.1136/jcp.17.1.45. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Eastham R. D. Adhesive platelets and myocardial infarction. Geriatrics. 1966 Jul;21(7):182–192. [PubMed] [Google Scholar]
  9. Eastham R. D., Avis P. R. Seasonal fluctuation in adhesive platelets during long-term anticoagulant therapy. Br J Haematol. 1966 Jan;12(1):39–43. doi: 10.1111/j.1365-2141.1966.tb00124.x. [DOI] [PubMed] [Google Scholar]
  10. Eastham R. D. Rapid whole-blood platelet counting using an electronic particle counter. J Clin Pathol. 1963 Mar;16(2):168–169. doi: 10.1136/jcp.16.2.168. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Gardner B. Studies of the zeta potential of cells and a silica particle in varying concentrations of albumin, calcium, sodium, plasma, and bile. J Lab Clin Med. 1969 Feb;73(2):202–209. [PubMed] [Google Scholar]
  12. Hampton J. R., Mitchell J. R. An estimate of the number of adenosine diphosphate binding sites on human platelets. Nature. 1966 Jul 16;211(5046):245–246. doi: 10.1038/211245a0. [DOI] [PubMed] [Google Scholar]
  13. Harrison M. J., Emmons P. R., Mitchell J. R. The variability of human platelet aggregation. J Atheroscler Res. 1967 Mar-Apr;7(2):197–205. doi: 10.1016/s0368-1319(67)80081-4. [DOI] [PubMed] [Google Scholar]
  14. Howe E. E., Bosshardt D. K. A study of factors influencing the enzymatic elimination of adenosine diphosphate in blood. Thromb Diath Haemorrh. 1968 Dec 31;20(3):377–383. [PubMed] [Google Scholar]
  15. Melchinger D., Nemerson Y. Randomness of platelet adhesiveness with respect to their ATP, O2 consumption, and size. J Appl Physiol. 1967 Feb;22(2):197–200. doi: 10.1152/jappl.1967.22.2.197. [DOI] [PubMed] [Google Scholar]
  16. Negus D., Pinto D. J., Brown N. Platelet adhesiveness in postoperative deep-vein thrombosis. Lancet. 1969 Feb 1;1(7588):220–224. doi: 10.1016/s0140-6736(69)91239-2. [DOI] [PubMed] [Google Scholar]
  17. Pegrum G. D., Shaw S., Wolff S. E. Measurement of platelet adhesiveness including the use of diatomaceous silica (celite). J Clin Pathol. 1967 Jan;20(1):65–69. doi: 10.1136/jcp.20.1.65. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Rozenberg M. C., Holmsen H. Adenine nucleotide metabolism of blood platelets. IV. Platelet aggregation response to exogenous ATP and ADP. Biochim Biophys Acta. 1968 Apr 22;157(2):280–288. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES