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. 1970 Jul;23(5):414–422. doi: 10.1136/jcp.23.5.414

A composite malignant tumour of the elderly female breast

D M Wayte 1,2, J B Stewart 1,2, C G McKenzie 1,2
PMCID: PMC476783  PMID: 4320045

Abstract

A composite malignant tumour arising in the breast of an elderly woman is described. The cystic tumour containing areas of squamous metaplasia, bone formation, adenocarcinoma, and osteosarcoma was surrounded by the typical changes of mammary dysplasia (fibroadenosis).

The classification and acceptance of such tumours is highly debatable. There is no one acceptable classification of breast sarcomas and hence the prognosis of such neoplasms, particularly those containing heterologous tissues, is poorly defined. Evidence is presented in support of such composite tumours as being definite entities which arise from the closely associated epithelial and mesenchymal components of the breast simultaneously.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. AZZOPARDI J. G., SMITH O. D. Salivary gland tumours and their mucins. J Pathol Bacteriol. 1959 Jan;77(1):131–140. doi: 10.1002/path.1700770114. [DOI] [PubMed] [Google Scholar]
  2. BOTHAM R. J., McDONALD J. R., CLAGETT O. T. Sarcoma of the mammary gland. Surg Gynecol Obstet. 1958 Jul;107(1):55–61. [PubMed] [Google Scholar]
  3. CONSTANCE T. J. Localised myositis ossificans. J Pathol Bacteriol. 1954 Oct;68(2):381–385. doi: 10.1002/path.1700680210. [DOI] [PubMed] [Google Scholar]
  4. CURRAN R. C., DODGE O. G. Sarcoma of breast, with particular reference to its origin from fibroadenoma. J Clin Pathol. 1962 Jan;15:1–16. doi: 10.1136/jcp.15.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. DAVIS H. H., SIMONS M., DAVIS J. B. CYSTIC DISEASE OF THE BREAST: RELATIONSHIP TO CARCINOMA. Cancer. 1964 Aug;17:957–978. doi: 10.1002/1097-0142(196408)17:8<957::aid-cncr2820170802>3.0.co;2-o. [DOI] [PubMed] [Google Scholar]
  6. Fawcett F. J. Sarcoma of breast. Br J Cancer. 1967 Jun;21(2):285–294. doi: 10.1038/bjc.1967.31. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Fidler I. J., Brodey R. S. A necropsy study of canine malignant mammary neoplasms. J Am Vet Med Assoc. 1967 Sep 15;151(6):710–715. [PubMed] [Google Scholar]
  8. Gonzalez-Licea A., Yardley J. H., Hartmann W. H. Malignant tumor of the breast with bone formation. Studies by light and electron microscopy. Cancer. 1967 Aug;20(8):1234–1247. doi: 10.1002/1097-0142(196708)20:8<1234::aid-cncr2820200808>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  9. JERNSTROM P., LINDBERG A. L., MELAND O. N. OSTEOGENIC SARCOMA OF THE MAMMARY GLAND. Am J Clin Pathol. 1963 Nov;40:521–526. doi: 10.1093/ajcp/40.5.521. [DOI] [PubMed] [Google Scholar]
  10. Kennedy T., Biggart J. D. Sarcoma of the breast. Br J Cancer. 1967 Dec;21(4):635–644. doi: 10.1038/bjc.1967.74. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Norris H. J., Taylor H. B. Sarcomas and related mesenchymal tumors of the breast. Cancer. 1968 Jul;22(1):22–28. doi: 10.1002/1097-0142(196807)22:1<22::aid-cncr2820220105>3.0.co;2-r. [DOI] [PubMed] [Google Scholar]
  12. OBERMAN H. A. CYSTOSARCOMA PHYLLODES; A CLINICOPATHOLOGIC STUDY OF HYPERCELLULAR PERIDUCTAL STROMAL NEOPLASMS OF BREAST. Cancer. 1965 Jun;18:697–710. doi: 10.1002/1097-0142(196506)18:6<697::aid-cncr2820180607>3.0.co;2-l. [DOI] [PubMed] [Google Scholar]
  13. Oberman H. A. Sarcomas of the breast. Cancer. 1965 Oct;18(10):1233–1243. doi: 10.1002/1097-0142(196510)18:10<1233::aid-cncr2820181004>3.0.co;2-m. [DOI] [PubMed] [Google Scholar]
  14. PANG L. S. Bony and cartilaginous tumours of the urinary bladder. J Pathol Bacteriol. 1958 Oct;76(2):357–377. doi: 10.1002/path.1700760205. [DOI] [PubMed] [Google Scholar]
  15. ROBB P. M., MACFARLANE A. Two rare breast tumours. J Pathol Bacteriol. 1958 Apr;75(2):293–298. doi: 10.1002/path.1700750207. [DOI] [PubMed] [Google Scholar]
  16. Shapiro R., Reichman L., Getzoff C., Weiss A. Osteosarcoma of breast metastasizing to the oral cavity. Oral Surg Oral Med Oral Pathol. 1967 Jan;23(1):58–61. doi: 10.1016/0030-4220(67)90485-9. [DOI] [PubMed] [Google Scholar]
  17. Smith B. H., Taylor H. B. The occurrence of bone and cartilage in mammary tumors. Am J Clin Pathol. 1969 May;51(5):610–618. doi: 10.1093/ajcp/51.5.610. [DOI] [PubMed] [Google Scholar]
  18. WILLIS R. A. Squamous-cell mammary carcinoma of predominantly fibrosarcoma-like structure. J Pathol Bacteriol. 1958 Oct;76(2):511–515. doi: 10.1002/path.1700760221. [DOI] [PubMed] [Google Scholar]
  19. YATES P. O., PAGET G. E. A mixed tumour of salivary gland showing bone formation with a histochemical study of the tumour mucoids. J Pathol Bacteriol. 1952 Oct;64(4):881–888. doi: 10.1002/path.1700640419. [DOI] [PubMed] [Google Scholar]

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