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. 1970 Sep;23(6):487–491. doi: 10.1136/jcp.23.6.487

Effect of treatment on renal function in severe osteomalacia due to Wilson's disease

Pauline Monro 1
PMCID: PMC476816  PMID: 5312232

Abstract

A patient with Wilson's disease presented at the age of 41 with a neurological defect and gross osteomalacia secondary to a defect of renal tubular reabsorption. He also showed the unusual features of a renal stone in the presence of the Fanconi syndrome and a relatively low alkaline phosphatase level, possibly due to the additional inherited defect of hypophosphatasia. During four years of treatment with penicillamine and calciferol clinical improvement was spectacular. Details of amino-acid clearances before and after treatment are given, and the results suggest that, as in the brain and the liver, the function of the distal renal tubules may be restored in Wilson's disease when copper is removed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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