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. 1970 Sep;23(6):514–516. doi: 10.1136/jcp.23.6.514

Serum alpha2-macroglobulin, transferrin, albumin, and IgG levels in preeclampsia

C H W Horne 1,2, P W Howie 1,2, R B Goudie 1,2
PMCID: PMC476820  PMID: 4991000

Abstract

A radial immunodiffusion technique has been used to measure levels of four serum proteins in preeclampsia with or without proteinuria and in normal pregnant and non-pregnant controls. In preeclampsia unaccompanied by proteinuria, albumin and transferrin levels are similar to those found in the normal pregnant controls, but there are significant falls in α2-macroglobulin and IgG. When preeclampsia is accompanied by proteinuria there is a marked fall in albumin and an increase in α2-macroglobulin. Since α2-macroglobulin has antiplasmin activity it is possible that increased levels of this protein in preeclampsia accompanied by proteinuria contribute to the intravascular coagulation which has been described in this disorder.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bonnar J., McNicol G. P., Douglas A. S. Fibrinolytic enzyme system and pregnancy. Br Med J. 1969 Aug 16;3(5667):387–389. doi: 10.1136/bmj.3.5667.387. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Ganrot P. O. Inhibition of plasmin activity by alpha-2-macroglobulin. Clin Chim Acta. 1967 May;16(2):328–329. doi: 10.1016/0009-8981(67)90201-x. [DOI] [PubMed] [Google Scholar]
  3. Horne C. H., Weir R. J., Howie P. W., Goudie R. B. Effect of combined oestrogen-progestogen oral contraceptives on serum-levels of alpha 2-macroglobulin, transferrin, albumin, and IgG. Lancet. 1970 Jan 10;1(7637):49–50. doi: 10.1016/s0140-6736(70)91841-6. [DOI] [PubMed] [Google Scholar]
  4. Hönger P. E. Albumin metabolism in pre-eclampsia. Acta Obstet Gynecol Scand. 1966;45(Suppl):104–105. doi: 10.3109/00016346609158610. [DOI] [PubMed] [Google Scholar]
  5. MORRIS R. H., VASSALLI P., BELLER F. K., MCCLUSKEY R. T. IMMUNOFLUORESCENT STUDIES OF RENAL BIOPSIES IN THE DIAGNOSIS OF TOXEMIA OF PREGNANCY. Obstet Gynecol. 1964 Jul;24:32–46. [PubMed] [Google Scholar]
  6. Robertson W. B., Brosens I., Dixon H. G. The pathological response of the vessels of the placental bed to hypertensive pregnancy. J Pathol Bacteriol. 1967 Apr;93(2):581–592. doi: 10.1002/path.1700930219. [DOI] [PubMed] [Google Scholar]
  7. SCHULTZE H. E., SCHWICK G. Quantitative immunologische Bestimmung von Plasmaproteinen. Clin Chim Acta. 1959 Jan;4(1):15–25. doi: 10.1016/0009-8981(59)90075-0. [DOI] [PubMed] [Google Scholar]
  8. Spetz S., Brody S. Serum proteins in pregnancy complicated by toxaemia. Acta Obstet Gynecol Scand. 1967;46(2):151–167. [PubMed] [Google Scholar]
  9. Thompson A., Horne C. H., Steele H., Goudie R. B. Concentrations of serum alpha-2-macroglobulin in twins. Nature. 1969 Jan 18;221(5177):289–290. doi: 10.1038/221289a0. [DOI] [PubMed] [Google Scholar]

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