Abstract
The sensitivity of collagen-induced platelet aggregation to aspirin was measured in vitro on platelet-rich plasma from 20 normal subjects and five patients with von Willebrand's disease. Although aspirin tolerance tests performed in vivo at the same time showed an abnormal prolongation of the bleeding time in three of the patients studied, no evidence was found for an enhanced sensitivity to aspirin in vitro.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Ashford T. P., Frieiman D. G. The role of the endothelium in the initial phases of thrombosis. An electron microscopic study. Am J Pathol. 1967 Feb;50(2):257–273. [PMC free article] [PubMed] [Google Scholar]
- BEAUMONT J. L., CAEN J., BERNARD J. Action hémorragipare de l'acide acétylsalicylique au cours des maladies du sang. Bull Mem Soc Med Hop Paris. 1955 Nov 18;71(27-28):1087–1092. [PubMed] [Google Scholar]
- BEAUMONT J. L., WILLIE A., LENEGRE J. Influence de l'acide acétyl-salicylique sur l'hémostase. Bull Mem Soc Med Hop Paris. 1955 Nov 18;71(27-28):1077–1087. [PubMed] [Google Scholar]
- BORN G. V. Aggregation of blood platelets by adenosine diphosphate and its reversal. Nature. 1962 Jun 9;194:927–929. doi: 10.1038/194927b0. [DOI] [PubMed] [Google Scholar]
- Quick A. J. Salicylates and bleeding: the aspirin tolerance test. Am J Med Sci. 1966 Sep;252(3):265–269. doi: 10.1097/00000441-196609000-00003. [DOI] [PubMed] [Google Scholar]
- Rorvik T. O., Holmsen I., Stormorken H. The release of ADP from red blood cells. Thromb Diath Haemorrh. 1968 Mar 31;19(1):77–83. [PubMed] [Google Scholar]
- SPAET T. H., ZUCKER M. B. MECHANISM OF PLATELET PLUG FORMATION AND ROLE OF ADENOSINE DIPHOSPHATE. Am J Physiol. 1964 Jun;206:1267–1274. doi: 10.1152/ajplegacy.1964.206.6.1267. [DOI] [PubMed] [Google Scholar]
- Weiss H. J., Aledort L. M., Kochwa S. The effect of salicylates on the hemostatic properties of platelets in man. J Clin Invest. 1968 Sep;47(9):2169–2180. doi: 10.1172/JCI105903. [DOI] [PMC free article] [PubMed] [Google Scholar]