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. Author manuscript; available in PMC: 2017 Feb 1.
Published in final edited form as: Placenta. 2015 Dec 13;38:16–23. doi: 10.1016/j.placenta.2015.12.002

Figure 3. Hemorrhages and altered histological appearance of Hectd1 mutant placentas.

Figure 3

A, B) E12.5 (A) wildtype (Hectd1+/+) and (B) mutant (Hectd1opm/opm) placentas viewed from the fetal side demonstrating the overall pale appearance and large hemorrhages (white arrowhead) in the mutant. C, D) H&E staining of midsagittal section of E12.5 (C) wildtype and (D) mutant placentas. The layers of the placenta are labeled as maternal decidua (MD), junctional zone (JZ) and labyrinthine zone (LZ). E, F) Higher magnification images of the labyrinthine zone of H&E stained wildtype (E) and mutant (F) placentas. Maternal (MBS) and fetal blood spaces (FBS) are labeled that contain anucleated and nucleated red blood cells, respectively. G) Stereological analysis of Hectd1 wildtype and mutant placentas. Three placentas and wildtype siblings at E12.5 from three separate litters were utilized in all groups, mean values ± S.E.M, significant difference assessed by paired t-test between mutant and wildtype (* indicates p < 0.05).