Abstract
An assessment of vitamin B12 absorption in neurological patients has been made by both serum and urine counting of 57Co cyanocobalamin during the conventional Schilling test. Although patients with pernicious anaemia, some with subacute combined degeneration of the cord, have been studied, emphasis in the discussion is placed on the significantly increased excretion of the radioactive vitamin in a group of patients with pituitary insufficiency. Results are also given for epileptic patients who have developed folate deficiency (as assessed by serum folate levels) coincidental with anticonvulsant therapy, as well as for some patients who have had neurological symptoms or signs following partial gastrectomy operations.
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Selected References
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- Ardeman S., Chanarin I., Krafchik B., Singer W. Addisonian pernicious anaemia and intrinsic factor antibodies in thyroid disorders. Q J Med. 1966 Jul;35(139):421–431. [PubMed] [Google Scholar]
- BERLIN R. Addison's disease: familial incidence and occurence in association with pernicious anemia. Acta Med Scand. 1952;144(1):1–6. doi: 10.1111/j.0954-6820.1952.tb15659.x. [DOI] [PubMed] [Google Scholar]
- BROITMAN S. A., BONDY D. C., YACHNIN I., HOSKINS L. C., INGBAR S., ZAMCHECK N. ABSORPTION AND DISPOSITION OF D-XYLOSE IN THYROTOXICOSIS AND MYXEDEMA. N Engl J Med. 1964 Feb 13;270:333–337. doi: 10.1056/NEJM196402132700703. [DOI] [PubMed] [Google Scholar]
- Brody E. A., Estren S., Herbert V. Coexistent pernicious anemia and malabsorption in four patients: including one whose malabsorption disappeared with vitamin B12 therapy. Ann Intern Med. 1966 Jun;64(6):1246–1251. doi: 10.7326/0003-4819-64-6-1246. [DOI] [PubMed] [Google Scholar]
- Carmel R., Herbert V. Correctable intestinal defect of vitamin B12 absorption in pernicious anemia. Ann Intern Med. 1967 Dec;67(6):1201–1207. doi: 10.7326/0003-4819-67-6-1201. [DOI] [PubMed] [Google Scholar]
- DELLER D. J., GERMAR H., WITTS L. J. Effect of food on absorption of radioactive vitamin B12. Lancet. 1961 Mar 18;1(7177):574–577. doi: 10.1016/s0140-6736(61)92246-2. [DOI] [PubMed] [Google Scholar]
- Donaldson D., Blight B. J., Lascelles P. T. An assessment of serum 57Co cyanocobalamin as an index of vitamin B12 absorption. J Clin Pathol. 1970 Oct;23(7):558–562. doi: 10.1136/jcp.23.7.558. [DOI] [PMC free article] [PubMed] [Google Scholar]
- FORSSELL J., HALONEN P. I. Thyroid function and pernicious anaemia; comments on some typical cases. Acta Med Scand. 1958 Sep 5;162(1):61–68. [PubMed] [Google Scholar]
- Foroozan P., Trier J. S. Mucosa of the small intestine in pernicious anemia. N Engl J Med. 1967 Sep 14;277(11):553–559. doi: 10.1056/NEJM196709142771101. [DOI] [PubMed] [Google Scholar]
- Goldberg L. S., Bickel Y. B., Fudenberg H. H. Immunologic approaches to malabsorption of vitamin B12. Arch Intern Med. 1969 Apr;123(4):397–400. [PubMed] [Google Scholar]
- HAURANI F. I., SHERWOOD W., GOLDSTEIN F. INTESTINAL MALABSORPTION OF VITAMIN B 12 IN PERNICIOUS ANEMIA. Metabolism. 1964 Nov;13:1342–1348. doi: 10.1016/0026-0495(64)90154-4. [DOI] [PubMed] [Google Scholar]
- Hunter R., Barnes J., Matthews D. M. Effect of folic-acid supplement on serum-vitamin-B12 levels in patients on anticonvulsants. Lancet. 1969 Sep 27;2(7622):666–667. doi: 10.1016/s0140-6736(69)90377-8. [DOI] [PubMed] [Google Scholar]
- LEES F. Radioactive vitamin B12 absorption in the megaloblastic anaemia caused by anticonvulsant drugs. Q J Med. 1961 Jul;30:231–248. [PubMed] [Google Scholar]
- LEITHOLD S. L., DAVID D., BEST W. R. Hypothyroidism with anemia demonstrating abnormal vitamin B12 absorption. Am J Med. 1958 Apr;24(4):535–548. doi: 10.1016/0002-9343(58)90294-8. [DOI] [PubMed] [Google Scholar]
- London D. R., Segal S. In vitro studies on the intestinal transport of amino acids and a sugar in hypothyroid rats. Endocrinology. 1967 Apr;80(4):623–628. doi: 10.1210/endo-80-4-623. [DOI] [PubMed] [Google Scholar]
- Reynolds E. H., Chanarin I., Milner G., Matthews D. M. Anticonvulsant therapy, folic acid and vitamin B12 metabolism and mental symptoms. Epilepsia. 1966 Dec;7(4):261–270. doi: 10.1111/j.1528-1157.1966.tb03806.x. [DOI] [PubMed] [Google Scholar]
- SAULI S., ASTALDI G., MALOSSINI L. HISTOPATHOLOGY OF INTESTINAL MUCOSA OBTAINED BY CROSBY'S BIOPSY IN PERNICIOUS ANEMIA BEFORE AND AFTER VITAMIN B12 TREATMENT. Acta Vitaminol Enzymol. 1963 Aug-Oct;17:143–152. [PubMed] [Google Scholar]
- Strickland R. G. Pernicious anemia and polyendocrine deficiency. Ann Intern Med. 1969 May;70(5):1001–1005. doi: 10.7326/0003-4819-70-5-1001. [DOI] [PubMed] [Google Scholar]
- TUDHOPE G. R., WILSON G. M. Deficiency of vitamin B12 in hypothyroidism. Lancet. 1962 Apr 7;1(7232):703–706. doi: 10.1016/s0140-6736(62)91652-5. [DOI] [PubMed] [Google Scholar]
- Turnbull A. L. Absorption of vitamin B12 in patients with anaemia after Polya partial gastrectomy. Br J Haematol. 1967 Sep;13(5):752–763. doi: 10.1111/j.1365-2141.1967.tb08841.x. [DOI] [PubMed] [Google Scholar]
- VILTER R. W. INTERRELATIONSHIPS BETWEEN FOLIC ACID, VITAMIN B12 AND ASCORBIC ACID IN THE MEGALOBLASTIC ANEMIAS. Medicine (Baltimore) 1964 Nov;43:727–730. doi: 10.1097/00005792-196411000-00016. [DOI] [PubMed] [Google Scholar]
- WATERS A. H., MOLLIN D. L. Observations on the metabolism of folic acid in pernicious anaemia. Br J Haematol. 1963 Jul;9:319–327. doi: 10.1111/j.1365-2141.1963.tb06556.x. [DOI] [PubMed] [Google Scholar]
- WATERS A. H., MOLLIN D. L. Studies on the folic acid activity of human serum. J Clin Pathol. 1961 Jul;14:335–344. doi: 10.1136/jcp.14.4.335. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ZIFFER H., GUTMAN A., PASHER I., SOBOTKA H., BAKER H. Vitamin B12 in thyrotoxicosis and myxedema. Proc Soc Exp Biol Med. 1957 Oct;96(1):229–230. doi: 10.3181/00379727-96-23438. [DOI] [PubMed] [Google Scholar]