Abstract
A case of generalized osteomyelitis due to Ps. aeruginosa is described. The condition had failed to respond to therapy with almost all antibiotics available but responded to long-term therapy with carbenicillin in very large doses, and it is suggested that this is now the treatment of choice for severe infections due to this organism.
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- Acred P., Brown D. M., Knudsen E. T., Rolinson G. N., Sutherland R. New semi-synthetic penicillin active against Pseudomonas pyocyanea. Nature. 1967 Jul 1;215(5096):25–30. doi: 10.1038/215025a0. [DOI] [PubMed] [Google Scholar]
- BATCHELOR F. R., DOYLE F. P., NAYLER J. H., ROLINSON G. N. Synthesis of penicillin: 6-aminopenicillanic acid in penicillin fermentations. Nature. 1959 Jan 24;183(4656):257–258. doi: 10.1038/183257b0. [DOI] [PubMed] [Google Scholar]
- Bodey G. P., Rodriguez V., Luce J. K. Carbenicillin therapy of gram-negative bacilli infections. Am J Med Sci. 1969 Jun;257(6):408–414. doi: 10.1097/00000441-196906000-00007. [DOI] [PubMed] [Google Scholar]
- Brumfitt W., Percival A., Leigh D. A. Clinical and laboratory studies with carbenicillin. A new penicillin active against Pseudomonas pyocyanea. Lancet. 1967 Jun 17;1(7503):1289–1293. doi: 10.1016/s0140-6736(67)91590-5. [DOI] [PubMed] [Google Scholar]
- Knudsen E. T., Rolinson G. N., Sutherland R. Carbenicillin: a new semisynthetic penicillin active against Pseudomonas pyocyanea. Br Med J. 1967 Jul 8;3(5557):75–78. doi: 10.1136/bmj.3.5557.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MATTERN H. PYOCYANEUS-SEPSIS (MIT MENINGITIS UND OSTEOMYELITIS) BEI SAEUGLINGEN. Monatsschr Kinderheilkd. 1965 Apr;113:338–339. [PubMed] [Google Scholar]
- Richardson A. E., James K. W., Spittle C. R., Robinson O. P. Experiences with carbenicillin in the treatment of septicaemia and meningitis. Postgrad Med J. 1968 Nov;44(517):844–847. doi: 10.1136/pgmj.44.517.844. [DOI] [PMC free article] [PubMed] [Google Scholar]

