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. 2016 Feb 15;95:62–69. doi: 10.1016/j.ymeth.2015.05.017

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© 2015 The Authors

This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).

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Fig. 3 — Focused high-throughput screen (HTS) results. Mass spectra labels indicate number of ligands (L) bound to each charge state of Aβ40. Binding modes as determined from the mass spectra are denoted as positive, negative, non-specific or colloidal. Molecule numbers 3 and 16 exhibit positive (specific) binding to Aβ40 (purple peaks); compounds 15 and 17 exhibit non-specific binding (pink peaks) and compound 9 exhibits colloidal binding (green peaks; each multimer of the small molecule is denoted nL, where n = oligomer number. The interaction of each small molecule with hIAPP is also shown [18].

Fig. 3 — Focused high-throughput screen (HTS) results. Mass spectra labels indicate number of ligands (L) bound to each charge state of Aβ40. Binding modes as determined from the mass spectra are denoted as positive, negative, non-specific or colloidal. Molecule numbers 3 and 16 exhibit positive (specific) binding to Aβ40 (purple peaks); compounds 15 and 17 exhibit non-specific binding (pink peaks) and compound 9 exhibits colloidal binding (green peaks; each multimer of the small molecule is denoted nL, where n = oligomer number. The interaction of each small molecule with hIAPP is also shown [18].