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. 1971 Mar;24(2):147–151. doi: 10.1136/jcp.24.2.147

A combined qualitative and quantitative procedure for the chemical analysis of urinary calculi

A Hodgkinson 1
PMCID: PMC476935  PMID: 5551382

Abstract

A better understanding of the physico-chemical principles underlying the formation of calculus has led to a need for more precise information on the chemical composition of stones. A combined qualitative and quantitative procedure for the chemical analysis of urinary calculi which is suitable for routine use is presented. The procedure involves five simple qualitative tests followed by the quantitative determination of calcium, magnesium, inorganic phosphate, and oxalate. These data are used to calculate the composition of the stone in terms of calcium oxalate, apatite, and magnesium ammonium phosphate. Analytical results and derived values for five representative types of calculi are presented.

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Selected References

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  1. DAWSON J. B., HEATON F. W. The determination of magnesium in biological materials by atomic absorption spectrophotometry. Biochem J. 1961 Jul;80:99–106. doi: 10.1042/bj0800099. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Finlayson B., Miller G. H., Jr Urine ion equilibria. A numerical approach demonstrated by application to antistone therapy. Invest Urol. 1969 Jan;6(4):428–440. [PubMed] [Google Scholar]
  3. Freeman J. A., Beeler M. F. Kidney stone analysis. Postgrad Med. 1969 Nov;46(5):51–56. doi: 10.1080/00325481.1969.11697297. [DOI] [PubMed] [Google Scholar]
  4. HOLT P. F., TARNOKY A. L. The analysis of calculi using microchemical methods. J Clin Pathol. 1953 May;6(2):114–117. doi: 10.1136/jcp.6.2.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Hodgkinson A., Peacock M., Nicholson M. Quantitative analysis of calcium-containing urinary calculi. Invest Urol. 1969 May;6(6):549–561. [PubMed] [Google Scholar]
  6. KIRBY J. K., PELPHREY C. F., RAINEY J. R., Jr The analysis of urinary calculi. Am J Clin Pathol. 1957 Mar;27(3):360–362. doi: 10.1093/ajcp/27.3_ts.360. [DOI] [PubMed] [Google Scholar]
  7. LEONARD R. H., BUTT A. J. Quantitative identification of urinary calculi. Clin Chem. 1955 Aug;1(4):241–248. [PubMed] [Google Scholar]
  8. Lonsdale K., Sutor D. J., Wooley S. Composition of urinary calculi by x-ray diffraction. Collected data from various localities. I. Norwich (England) and District, 1773-1961. Br J Urol. 1968 Feb;40(1):33–36. doi: 10.1111/j.1464-410x.1968.tb11810.x. [DOI] [PubMed] [Google Scholar]
  9. Mathies J. C., Lund P. K. X-ray spectroscopy in biology and medicine. 8. Micro and ultramicro procedures for the quantitative determination of calcium, phosphorus, and sulfur in urinary calculi. Clin Chem. 1967 Nov;13(11):962–969. [PubMed] [Google Scholar]
  10. Maurer C. Analysengang zur Beurteilung der quantitativen Zusammensetzung von Harmkonkrementen. Urologe. 1969 Jul-Aug;8(4):189–193. [PubMed] [Google Scholar]
  11. McIntosh J. F., Salter R. W. THE QUALITATIVE EXAMINATION OF URINARY CALCULI. J Clin Invest. 1942 Nov;21(6):751–754. doi: 10.1172/JCI101351. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Pak C. Y. Physicochemical basis for formation of renal stones of calcium phosphate origin: calculation of the degree of saturation of urine with respect to brushite. J Clin Invest. 1969 Oct;48(10):1914–1922. doi: 10.1172/JCI106158. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Pollack S. S., Carlson G. L. A comparison of x-ray diffraction and infrared technics for identifying kidney stones. Am J Clin Pathol. 1969 Dec;52(6):656–660. doi: 10.1093/ajcp/52.6.656. [DOI] [PubMed] [Google Scholar]
  14. Robertson W. G., Peacock M., Nordin B. E. Activity products in stone-forming and non-stone-forming urine. Clin Sci. 1968 Jun;34(3):579–594. [PubMed] [Google Scholar]
  15. Rosenthal A. F., Yaseen A. Improved qualitative screening test for cystinuria and homocystinuria. Clin Chim Acta. 1969 Nov;26(2):363–364. doi: 10.1016/0009-8981(69)90393-3. [DOI] [PubMed] [Google Scholar]
  16. Schneider H. J. Die anorganischen Bestandteile der Nierensteine und deren Einfluss auf die Steinart. Urologe. 1968 Nov-Dec;7(6):347–352. [PubMed] [Google Scholar]
  17. TSAY Y. C. Application of infrared spectroscopy to analysis of urinary calculi. J Urol. 1961 Dec;86:838–854. doi: 10.1016/S0022-5347(17)65267-4. [DOI] [PubMed] [Google Scholar]
  18. Thind S. K., Nath R. Chemical analysis of urinary calculi in Chandigarh area. Indian J Med Res. 1969 Sep;57(9):1790–1801. [PubMed] [Google Scholar]
  19. ZETTNER A., SELIGSON D. APPLICATION OF ATOMIC ABSORPTION SPECTROPHOTOMETRY IN THE DETERMINATION OF CALCIUM IN SERUM. Clin Chem. 1964 Oct;10:869–890. [PubMed] [Google Scholar]

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