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. 1971 May;24(4):336–342. doi: 10.1136/jcp.24.4.336

Porphyrin biosynthesis in the erythrocytes of patients with sideropenic anaemias

O Gutniak 1,2, M Kopeć 1,2, J Nieczaj 1,2
PMCID: PMC476987  PMID: 5314650

Abstract

The ability of erythrocytes to synthesize porphyrins from δ-aminolaevulic acid was compared in healthy people, patients with true iron-deficiency anaemia, and anaemic patients with rheumatoid arthritis. Porphyrin synthesis was found to be impaired in true iron deficiency but not in rheumatoid arthritis cases showing a similar degree of anaemia. The δ-aminolaevulic acid dehydratase activity and the rate of porphobilinogen synthesis did not differ in the three groups studied. The most probable mechanism of impairment of porphyrin synthesis in the anaemia of true iron deficiency seems to be a partial block in the conversion of porphobilinogen into porphyrins. High endogenous and exogenous protoporphyrin concentration did not affect the synthesis of porphyrins.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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