Abstract
The levels of four serum proteins, assayed by a radial immunodiffusion technique, have been measured in healthy women who had been given either the oestrogen or progestogen component of a combined oral contraceptive preparation for three weeks. Raised α2-macroglobulin and transferrin levels were found after oestrogen treatment but albumin and IgG did not significantly alter. In the progestogen-treated group all four proteins remained unchanged. The four proteins have also been assayed at frequent intervals during the normal menstrual cycle. No evidence of cyclical variation was found.
Full text
PDF


Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Briggs M., Staniford M. Oral contraceptives and blood-iron. Lancet. 1969 Oct 4;2(7623):742–742. doi: 10.1016/s0140-6736(69)90450-4. [DOI] [PubMed] [Google Scholar]
- FAHEY J. L., MCKELVEY E. M. QUANTITATIVE DETERMINATION OF SERUM IMMUNOGLOBULINS IN ANTIBODY-AGAR PLATES. J Immunol. 1965 Jan;94:84–90. [PubMed] [Google Scholar]
- Honger P. E., Rossing N. Albumin metabolism and oral contraception. Clin Sci. 1969 Feb;36(1):41–45. [PubMed] [Google Scholar]
- Horne C. H., Weir R. J., Howie P. W., Goudie R. B. Effect of combined oestrogen-progestogen oral contraceptives on serum-levels of alpha 2-macroglobulin, transferrin, albumin, and IgG. Lancet. 1970 Jan 10;1(7637):49–50. doi: 10.1016/s0140-6736(70)91841-6. [DOI] [PubMed] [Google Scholar]
- Laurell C. B., Kullander S., Thorell J. Effect of administration of a combined estrogen-progestin contraceptive on the level of individual plasma proteins. Scand J Clin Lab Invest. 1968;21(4):337–343. doi: 10.3109/00365516809077003. [DOI] [PubMed] [Google Scholar]
- Laurell C. B., Kullander S., Thorell J. Plasma proteins after continuous, oral use of a progestogen--chloromadionone acetate--as a contraceptive. Scand J Clin Lab Invest. 1969 Dec;24(4):387–389. doi: 10.3109/00365516909080176. [DOI] [PubMed] [Google Scholar]
- Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
- Musa B. U., Doe R. P., Seal U. S. Serum protein alterations produced in women by synthetic estrogens. J Clin Endocrinol Metab. 1967 Oct;27(10):1463–1469. doi: 10.1210/jcem-27-10-1463. [DOI] [PubMed] [Google Scholar]
- Thompson A., Horne C. H., Steele H., Goudie R. B. Concentrations of serum alpha-2-macroglobulin in twins. Nature. 1969 Jan 18;221(5177):289–290. doi: 10.1038/221289a0. [DOI] [PubMed] [Google Scholar]
- YOUNG D. S., HICKS J. M. METHOD FOR THE AUTOMATIC DETERMINATION OF SERUM IRON. J Clin Pathol. 1965 Jan;18:98–102. doi: 10.1136/jcp.18.1.98. [DOI] [PMC free article] [PubMed] [Google Scholar]
