Table 3. MicroRNAs validated on validation set 1 (N = 28) and their correlation with TTP (weeks).
MiRNA | Patients (N = 28) | Median TTP (weeks) | Log-Rank P | Adjusted HR | 95% CI | P |
---|---|---|---|---|---|---|
MiR-31-3p | ||||||
Low ≤ 0.0155 | 21 | 49 | < 0.0001 | 35.051 | 6.887 to 178.412 | <0.001 |
High > 0.0155 | 7 | 16 | ||||
MiR-31-5p | ||||||
Low ≤ 0.1378 | 19 | 49 | 0.001 | 7.369 | 2.242 to 24.219 | <0.001 |
High > 0.1378 | 9 | 16 | ||||
MiR-378a-5p | ||||||
Low ≤ 0.0734 | 15 | 22 | 0.1406 | 0.553 | 0.251 to 1.216 | |
High > 0.0734 | 13 | 49 | ||||
MiR-595 | ||||||
Low ≤ 0.0142 | 8 | 29.5 | 0.8797 | 0.935 | 0.393 to 2.225 | |
High > 0.0142 | 20 | 31 | ||||
MiR-192 | ||||||
Low ≤ 4.7538 | 18 | 31 | 0.6333 | 1.290 | 0.369 to 1.834 | |
High > 4.7538 | 10 | 40 | ||||
MiR-455 | ||||||
Low ≤ 0.0753 | 20 | 37.5 | 0.5370 | 1.348 | 0.522 to 3.483 | |
High > 0.0753 | 8 | 19.5 | ||||
MiR-30a-3p | ||||||
Low ≤ 0.065 | 16 | 37.5 | 0.6047 | 1.238 | 0.552 to 2.777 | |
High > 0.065 | 12 | 22 | ||||
MiR-636* | ||||||
MiR-32* |
Ct values of miR-636 and miR-32 were higher than 35 and considered negative.