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. 2015 Oct 8;6(36):38705–38718. doi: 10.18632/oncotarget.5478

Figure 2. miR-214 enhances LAD cell migration and invasion in vitro and promotes their metastasis in vivo.

Figure 2

A, B. and C. The migration and invasion abilities of A549 (A), NCI-H1650 (B) and SPC-A1 cells (C) when transfected with the miR-214 over-expression vector or an empty vector as assessed by Transwell migration and Matrigel invasion assay for 24 hours. D. A wound-healing assay performed with miR-214-over-expressed A549 cells at 0, 24, and 48 hours, and the average wound-healing area. E. Images showing the lung metastatic foci in recipient mice on day 30 after vein injection and hematoxylin and eosin (H&E) staining (n = 10). F–G. The quantitation of metastatic nodes and weights in the lungs of recipient mice (n = 10). All experiments were performed at least three times, and the data are expressed as means ± SD. The statistical significance of differences was measured by unpaired student's t-test. *P < 0.05, **P < 0.01, ***P < 0.001.