Table 2. Multi-variate analysis by Cox hazard regression for overall survival, disease-free survival and metastasis in 14-3-3ε positive HCC patients.
| Variable | Overall survival | Disease-free survival | Metastasis | |||
|---|---|---|---|---|---|---|
| Hazard ratio (95% confidence interval) |
p-value | Hazard ratio (95% confidence interval) |
p-value | Hazard ratio (95% confidence interval) |
p-value | |
| Age (≧ 60 vs. < 60 y/o) |
1.532 (0.729–3.218) |
0.260 | 0.819 (0.421–1.592) |
0.556 | 0.818 (0.315–2.123) |
0.680 |
| Sex (Female vs. male) |
0.509 (0.198–1.306) |
0.160 | 1.137 (0.555–2.328) |
0.726 | 1.564 (0.546–4.479) |
0.404 |
| BCLC stage (Early vs. Intermediate/late) |
0.753 (0.359–1.580) |
0.453 | 0.652 (0.301–1.414) |
0.279 | 0.402 (0.151–1.070) |
0.068 |
| AFP level (≧ 80 vs. < 80 ng/ml) |
1.309 (0.589–2.910) |
0.509 | 1.141 (0.544–2.393) |
0.727 | 0.519 (0.148–1.826) |
0.307 |
| Increased AKR1B10 (Yes vs. No) |
0.376 (0.171–0.827) |
0.015* | 0.646 (0.340–1.227) |
0.182 | 0.262 (0.097–0.731) |
0.011* |
*
p < 0.05