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. 2015 Jul 30;6(36):39225–39234. doi: 10.18632/oncotarget.4407

Figure 3. Knockdown of miR-454 inhibited HCC cell proliferation.

Figure 3

A. miR-454 mimics can enhance the expression of miR-454 and miR-454 inhibitor can repress the expression of miR-454 in the HepG2 cells. B. CCK-8 proliferation assay showed that overexpression of miR-454 significantly promoted the growth rate of cells compared with control cells in HepG2 cells. Conversely, miR-211 inhibitor significantly inhibited the proliferation of the HepG2 cells. C. The mRNA of Ki-67 was measured by using qRT-PCR. D. The protein of Ki-67 was measured by using western blot. *p < 0.05, **p < 0.01, and ***p < 0.001.