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. 1971 Oct;24(7):626–632. doi: 10.1136/jcp.24.7.626

Identification of a congenital defect of factor VII in a colony of beagle dogs: the clinical use of the plasma

Part I Identification of the clotting defect in a colony of beagles

L Poller 1, Jean M Thomson 1, C H J Sear 1, Wendy Thomas 1
PMCID: PMC477109  PMID: 5165796

Abstract

A severe, pure deficiency of factor VII has been defined in haematological and biochemical terms in the Alderley Park colony of beagle dogs. By modification of the conventional factor VII assay to improve its specificity an apparent low activity of between 1 and 2·5% of the normal beagle has been found.

When this plasma is used as a substrate for factor VII assays it compares well with human factor VII-deficient plasma in the measurement of both raised and depressed factor VII activity. It also appears to be a valuable reagent in the quality control of tissue thromboplastin extracts.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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