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. 1972 Feb;25(2):135–140. doi: 10.1136/jcp.25.2.135

Immunoglobulin levels in infantile pneumocystosis

Elfriede Kohout 1,2, Cornelius Post 1,2, Bahram Azadeh 1,2, Werner Dutz 1,2, Bashi Bandarizadeh 1,2, Darius Kadivar 1,2
PMCID: PMC477243  PMID: 4536973

Abstract

Two hundred and twelve determinations of IgA, IgG, and IgM were performed in 50 infants during an epidemic of interstitial plasma cell pneumonia. Criteria for diagnosis are discussed. The immunoglobulin levels in pneumocystic, non-pneumocystic, and normal American infants are compared. An analysis of the findings in individual cases reveals a time-related immunoglobulin response, which helps to elucidate the pathogenicity of the disease.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COONS A. H., KAPLAN M. H. Localization of antigen in tissue cells; improvements in a method for the detection of antigen by means of fluorescent antibody. J Exp Med. 1950 Jan 1;91(1):1–13. doi: 10.1084/jem.91.1.1. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. COONS A. H., LEDUC E. H., KAPLAN M. H. Localization of antigen in tissue cells. VI. The fate of injected foreign proteins in the mouse. J Exp Med. 1951 Feb;93(2):173–188. doi: 10.1084/jem.93.2.173. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Creamer B., Dutz W., Post C. Small-intestinal lesion of chronic diarrhoea and marasmus in Iran. Lancet. 1970 Jan 3;1(7636):18–20. doi: 10.1016/s0140-6736(70)90526-x. [DOI] [PubMed] [Google Scholar]
  4. DVORAK J., JIROVEC O. Diagnostik und Therapie der durch Pneumocystis carinii verursachten parasitären atypischen Pneumonien bei Säuglingen. Acta Paediatr. 1953 May;42(3):232–245. doi: 10.1111/j.1651-2227.1953.tb05587.x. [DOI] [PubMed] [Google Scholar]
  5. Dutz W. Pneumocystis carinii pneumonia. Pathol Annu. 1970;5:309–341. [PubMed] [Google Scholar]
  6. Esterly J. A., Warner N. E. Pneumocystis carinii pneumonia. Twelve cases in patients with neoplastic lymphoreticular disease. Arch Pathol. 1965 Nov;80(5):433–441. [PubMed] [Google Scholar]
  7. Fischer R., Becker H. D., Joist J. H., Tismer R. Pneumocystis-carinii-Pneumonie beim Erwachsenen. Dtsch Med Wochenschr. 1969 Oct 17;94(42):2135–2140. doi: 10.1055/s-0028-1110403. [DOI] [PubMed] [Google Scholar]
  8. Fulginiti V. A., Sieber O. F., Jr, Claman H. N., Merrill D. Serum immunoglobulin measurement during the first year of life and in immunoglobulin-deficiency states. J Pediatr. 1966 May;68(5):723–730. doi: 10.1016/s0022-3476(66)80444-4. [DOI] [PubMed] [Google Scholar]
  9. GAJDUSEK D. C. Pneumocystis carinii; etiologic agent of interstitial plasma cell pneumonia of premature and young infants. Pediatrics. 1957 Apr;19(4 Pt 1):543–565. [PubMed] [Google Scholar]
  10. Goetz O. Serologische Untersuchungen bei einem sogenannten Altersfall von Pneumocystis Carinii-Pneumonie. Z Kinderheilkd. 1966;95(1):1–10. [PubMed] [Google Scholar]
  11. HAMPERL H. Uber heilende und abortive Pneumocystis-Pneumonie. Virchows Arch Pathol Anat Physiol Klin Med. 1957;330(3):325–336. doi: 10.1007/BF00954963. [DOI] [PubMed] [Google Scholar]
  12. Hamlin W. B. Pneumocystis carinii. JAMA. 1968 Apr 8;204(2):173–174. [PubMed] [Google Scholar]
  13. JIROVEC O., VANEK J. Zur Morphologie der Pneumocystis carinii und zur Pathogenese der Pneumocystis-Pneumonie. Zentralbl Allg Pathol. 1954 Nov 20;92(10-11):424–437. [PubMed] [Google Scholar]
  14. KOSSEL A. [Interstitial plasma cell pneumonia in older children following prolonged corticosteroid treatment. Report on 13 cases]. Dtsch Med Wochenschr. 1962 Jun 1;87:1133–1139. doi: 10.1055/s-0028-1111876. [DOI] [PubMed] [Google Scholar]
  15. KOUVALAINEN K., HJELT L., WASZ-HOECKERT O. MARKED ELEVATION OF BETA-2M GLOBULIN IN A PATIENT WITH INTERSTITIAL PLASMS CELL PNEUMONIA. Acta Paediatr. 1964 Sep;53:465–469. doi: 10.1111/j.1651-2227.1964.tb07252.x. [DOI] [PubMed] [Google Scholar]
  16. Koltay M., Illyés M. A study of immunoglobulins in the blood serum of infants with interstitial plasma cellular pneumonia. Acta Paediatr Scand. 1966 Sep;55(5):489–496. doi: 10.1111/j.1651-2227.1966.tb15240.x. [DOI] [PubMed] [Google Scholar]
  17. LINHARTOVA A. Herdförmige, klinisch latente Pneumozystis Pneumonie. Zentralbl Allg Pathol. 1958 Sep 30;98(3-4):183–188. [PubMed] [Google Scholar]
  18. MARSHALL W. C., WESTON H. J., BODIAN M. PNEUMOCYSTIS CARINII PNEUMONIA AND CONGENITAL HYPOGAMMAGLOBULINAEMIA. Arch Dis Child. 1964 Feb;39:18–25. doi: 10.1136/adc.39.203.18. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. POST C., DUTZ W., NASARIAN I. ENDEMIC PNEUMOCYSTIS CARINII PNEUMONIA IN SOUTH IRAN. Arch Dis Child. 1964 Feb;39:35–40. doi: 10.1136/adc.39.203.35. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Post C., Fakouhi T., Dutz W., Bandarizadeh B., Kohout E. E. Prophylaxis of epidemic infantile pneumocystosis with a 20:1 sulfadoxine+pyrimethamine combination. Curr Ther Res Clin Exp. 1971 May;13(5):273–279. [PubMed] [Google Scholar]
  21. Pozzuoli R., Corda G. Caratterizzazione delle immuno-globuline nella pneumocistosi infantile. Clin Pediatr (Bologna) 1966 Nov;48(11):541–554. [PubMed] [Google Scholar]
  22. Pozzuoli R., Parma A., Costanzi G. Aspetti isto-immunologici della polmonite interstiziale plasmacellulare da pneumocystis carinii. Minerva Med. 1966 Dec 19;57(101):4344–4348. [PubMed] [Google Scholar]
  23. RIFKIND D., STARZL T. E., MARCHIORO T. L., WADDELL W. R., ROWLANDS D. T., Jr, HILL R. B., Jr TRANSPLANTATION PNEUMONIA. JAMA. 1964 Sep 14;189:808–812. doi: 10.1001/jama.1964.03070110010002. [DOI] [PMC free article] [PubMed] [Google Scholar]
  24. ROBBINS J. B., MILLER R. H., AREAN V. M., PEARSON H. A. SUCCESSFUL TREATMENT OF PNEUMOCYSTIS CARINII PNEUMONITIS IN A PATIENT WITH CONGENITAL HYPOGAMMAGLOBULINEMIA. N Engl J Med. 1965 Apr 8;272:708–713. doi: 10.1056/NEJM196504082721402. [DOI] [PubMed] [Google Scholar]
  25. SHELDON W. H. Experimental pulmonary Pneumocystis carinii infection in rabbits. J Exp Med. 1959 Jul 1;110(1):147–160. doi: 10.1084/jem.110.1.147. [DOI] [PMC free article] [PubMed] [Google Scholar]
  26. South M. A., Warwick W. J., Wolheim F. A., Good R. A. The IgA system. 3. IgA levels in the serum and saliva of pediatric patients--evidence for a local immunological system. J Pediatr. 1967 Nov;71(5):645–653. doi: 10.1016/s0022-3476(67)80199-9. [DOI] [PubMed] [Google Scholar]
  27. Thomas S. F., Dutz W., Khodadad E. J. Pneumocystis Carinii pneumonia (plasma cell pneumonia); roentgenographic, pathologic and clinical correlation. Am J Roentgenol Radium Ther Nucl Med. 1966 Oct;98(2):318–322. [PubMed] [Google Scholar]
  28. VIVELL O. Ein neues stabiles Antigen für die Serodiagnose der interstitiellen plasmazellulären Pneumonie junger Säuglinge und Frühgeburten. Dtsch Med Wochenschr. 1955 Sep 16;80(37):1357–1357. doi: 10.1055/s-0028-1116202. [DOI] [PubMed] [Google Scholar]
  29. WOODWARD S. C., SHELDON W. H. Subclinical pneumocystis carinii pneumonitis in adults. Bull Johns Hopkins Hosp. 1961 Oct;109:148–159. [PubMed] [Google Scholar]

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