Skip to main content
NCBI home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1972 Apr;25(4):344–348. doi: 10.1136/jcp.25.4.344

The relationship between fluorescent, agglutinating, and precipitating antibodies to Candida albicans and their immunoglobin classes

T Lehner 1,2, Helen R Buckley 1,2, I G Murray 1,2
PMCID: PMC477308  PMID: 4555044

Abstract

A parallel study of fluorescent, agglutinating, and precipitating antibodies to Candida albicans revealed that precipitating antibodies belong to the IgG class, whereas agglutinating antibodies reside in the IgG, IgM, and IgA classes. The three types as well as the three classes of antibodies were found in Candida endocarditis and mucocutaneous candidiasis. Immuno-absorption studies suggest that the three serological tests estimate antibodies to mannan determinants of Candida albicans.

Full text

PDF
344

Images in this article

346Image
on p.346

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. COMAISH J. S., GIBSON B., GREEN C. A. Candidiasis--serology and diagnosis. J Invest Dermatol. 1963 Mar;40:139–142. [PubMed] [Google Scholar]
  2. Chew W. H., Theus T. L. Candida precipitins. J Immunol. 1967 Feb;98(2):220–224. [PubMed] [Google Scholar]
  3. Esterly N. B. Serum antibody titers to Candida albicans utilizing an immunofluorescent technic. Am J Clin Pathol. 1968 Sep;50(3):291–296. doi: 10.1093/ajcp/50.3.291. [DOI] [PubMed] [Google Scholar]
  4. Hasenclever H. F., Mitchell W. O. A study of yeast surface antigens by agglutination inhibition. Sabouraudia. 1964 Oct;3(4):288–300. doi: 10.1080/00362176485190511. [DOI] [PubMed] [Google Scholar]
  5. KEMP G., SOLOTOROVSKY M. LOCALIZATION OF ANTIGENS IN MECHANICALLY DISRUPTED CELLS OF CERTAIN SPECIES OF THE GENERA CANDIDA AND TORULOPSIS. J Immunol. 1964 Aug;93:305–314. [PubMed] [Google Scholar]
  6. KESSLER G., NICKERSON W. J. Glucomannan-protein complexes from cell walls of yeasts. J Biol Chem. 1959 Sep;234:2281–2285. [PubMed] [Google Scholar]
  7. LEVY H. B., SOBER H. A. A simple chromatographic method for preparation of gamma globulin. Proc Soc Exp Biol Med. 1960 Jan;103:250–252. doi: 10.3181/00379727-103-25476. [DOI] [PubMed] [Google Scholar]
  8. Lehner T. Characterization of mucosal antibodies in recurrent aphthous ulceration and Behcet's syndrome. Arch Oral Biol. 1969 Jul;14(7):843–853. doi: 10.1016/0003-9969(69)90174-5. [DOI] [PubMed] [Google Scholar]
  9. Lehner T. Immunofluorescence study of Candida albicans in candidiasis, carriers and controls. J Pathol Bacteriol. 1966 Jan;91(1):97–104. doi: 10.1002/path.1700910114. [DOI] [PubMed] [Google Scholar]
  10. Lehner T. Serum fluorescent antibody and immunoglobulin estimations in candidosis. J Med Microbiol. 1970 Aug;3(3):475–481. doi: 10.1099/00222615-3-3-475. [DOI] [PubMed] [Google Scholar]
  11. Murray I. G., Buckley H. R., Turner G. C. Serological evidence of Candida infection after open-heart surgery. J Med Microbiol. 1969 Nov 4;2(4):463–469. doi: 10.1099/00222615-2-4-463. [DOI] [PubMed] [Google Scholar]
  12. Pepys J., Faux J. A., McCarthy D. S., Hargreave F. E. Candida albicans precipitins in respiratory disease in man. J Allergy. 1968 Jun;41(6):305–318. doi: 10.1016/0021-8707(68)90073-7. [DOI] [PubMed] [Google Scholar]
  13. Pike R. M. Antibody heterogeneity and serological reactions. Bacteriol Rev. 1967 Jun;31(2):157–174. doi: 10.1128/br.31.2.157-174.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. STALLYBRASS F. C. CANDIDA PRECIPITINS. J Pathol Bacteriol. 1964 Jan;87:89–97. doi: 10.1002/path.1700870113. [DOI] [PubMed] [Google Scholar]
  15. Taschdjian C. L., Kozinn P. J., Caroline L. Immune studies in candidiasis. 3. Precipitating antibodies in systemic candidiasis. Sabouraudia. 1964 Oct;3(4):312–320. doi: 10.1080/00362176485190551. [DOI] [PubMed] [Google Scholar]
  16. WINNER H. I. A study of Candida albicans agglutinins in human sera. J Hyg (Lond) 1955 Dec;53(4):509–512. doi: 10.1017/s0022172400001005. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES