Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1972 Aug;25(8):705–707. doi: 10.1136/jcp.25.8.705

Chromosome abnormalities in chronic active hepatitis

D T Stefanescu 1,2,3, M Moanga 1,2,3, M Teodorescu 1,2,3, J Brucher 1,2,3
PMCID: PMC477482  PMID: 5076805

Abstract

An investigation on human peripheral blood lymphocyte chromosomes in chronic active hepatitis was carried out. A higher percentage of chromatid and chromosome lesions was recorded in all patients studied as compared with control groups—normal individuals, healthy subjects who had suffered from acute viral hepatitis, patients with alcoholic liver disease, and patients with mechanical jaundice due to cancer. The possible origin of these abnormalities is discussed.

Full text

PDF
705

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baroyan O. V., Barinsky I. F., Shatkin A. A. Inhibitory effect of sera from patients with Botkin's viral hepatitis on the differentiation and mitotic activity of lymphocytes and integrity of their chromosomes in the course of serial passaging in vitro. Acta Virol. 1970 Jul;14(4):324–324. [PubMed] [Google Scholar]
  2. Bayer M. E., Blumberg B. S., Werner B. Particles associated with Australia antigen in the sera of patients with leukaemia, Down's Syndrome and hepatitis. Nature. 1968 Jun 15;218(5146):1057–1059. doi: 10.1038/2181057a0. [DOI] [PubMed] [Google Scholar]
  3. Blumberg B. S., Sutnick A. I., London W. T., Millman I. Australia antigen and hepatitis. N Engl J Med. 1970 Aug 13;283(7):349–354. doi: 10.1056/NEJM197008132830707. [DOI] [PubMed] [Google Scholar]
  4. Brucher J., Teodorescu M., Stefănescu D. T., Tiţu H. Proliferative activity and antibody synthesis in cultures of lymphoid cells grown in a serum free medium. Arch Roum Pathol Exp Microbiol. 1972 Mar;31(1):105–111. [PubMed] [Google Scholar]
  5. Elling P., Nielsen J. O., Dietrichson O. Australia antigen in patients with various liver diseases. Acta Pathol Microbiol Scand B Microbiol Immunol. 1970;78(6):657–663. doi: 10.1111/j.1699-0463.1970.tb04354.x. [DOI] [PubMed] [Google Scholar]
  6. Gocke D. J., Kavey N. B. Hepatitis antigen. Correlation with disease and infectivity of blood-donors. Lancet. 1969 May 31;1(7605):1055–1059. doi: 10.1016/s0140-6736(69)91701-2. [DOI] [PubMed] [Google Scholar]
  7. Hadziyannis S. J., Merikas G. E., Afroudakis A. P. Hepatitis-associated antigen in chronic liver disease. Lancet. 1970 Jul 11;1(7663):100–100. doi: 10.1016/s0140-6736(70)92672-3. [DOI] [PubMed] [Google Scholar]
  8. Matsaniotis N., Kiossoglou K., Maounis F., Anagnostakis D. Chromosomal aberrations in infective hepatitis. J Clin Pathol. 1970 Oct;23(7):553–557. doi: 10.1136/jcp.23.7.553. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Maynard E. P., 3rd, Sadikali F., Anthony P. P., Barker L. F. Hepatitis-associated antigen and cirrhosis in Uganda. Lancet. 1970 Dec 26;2(7687):1326–1328. doi: 10.1016/s0140-6736(70)92357-3. [DOI] [PubMed] [Google Scholar]
  10. Mella B., Lang D. J. Leukocyte mitosis: suppression in vitro associated with acute infectious hepatitis. Science. 1967 Jan 6;155(3758):80–81. doi: 10.1126/science.155.3758.80. [DOI] [PubMed] [Google Scholar]
  11. Nielsen J. O., Dietrichson O., Elling P., Christoffersen P. Incidence and meaning of persistence of Australia antigen in patients with acute viral hepatitis: development of chronic hepatitis. N Engl J Med. 1971 Nov 18;285(21):1157–1160. doi: 10.1056/NEJM197111182852101. [DOI] [PubMed] [Google Scholar]
  12. Nász I., Kulcsár G., Dán P., Sallay K. A possible pathogenic role for virus-carrier lymphocytes. J Infect Dis. 1971 Aug;124(2):214–216. doi: 10.1093/infdis/124.2.214. [DOI] [PubMed] [Google Scholar]
  13. Okochi K., Murakami S. Observations on Australia antigen in Japanese. Vox Sang. 1968;15(5):374–385. doi: 10.1111/j.1423-0410.1968.tb04078.x. [DOI] [PubMed] [Google Scholar]
  14. Prince A. M., Leblanc L., Krohn K., Masseyeff R., Alpert M. E. S.H. antigen and chronic liver disease. Lancet. 1970 Oct 3;2(7675):717–718. doi: 10.1016/s0140-6736(70)91981-1. [DOI] [PubMed] [Google Scholar]
  15. Wright R., McCollum R. W., Klatskin G. Australia antigen in acute and chronic liver disease. Lancet. 1969 Jul 19;2(7612):117–121. doi: 10.1016/s0140-6736(69)92437-4. [DOI] [PubMed] [Google Scholar]
  16. el-Alfi O. S., Smith P. M., Biesele J. J. Chromosomal breaks in human leucocyte cultures induced by an agent in the plasma of infectious hepatitis patients. Hereditas. 1965;52(3):285–294. doi: 10.1111/j.1601-5223.1965.tb01961.x. [DOI] [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES