Skip to main content
PMC home page
Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1972 Aug;25(8):708–712. doi: 10.1136/jcp.25.8.708

Resistance of Staphylococcus aureus to sulphamethoxazole and trimethoprim

L S Nakhla 1
PMCID: PMC477483  PMID: 5076806

Abstract

Strains of Staphylococcus aureus isolated from the lesions of hospital patients were surveyed for resistance to sulphamethoxazole and to trimethoprim. Of 675 strains tested, 18·5% were resistant to sulphamethoxazole and 1·6% to trimethoprim. All the trimethoprim-resistant strains were resistant to sulphamethoxazole and to a 1:20 mixture of the two drugs. Trimethoprim-resistant strains were on average more resistant to sulphamethoxazole than were trimethoprim-sensitive strains. They were all resistant to several other antimicrobial agents. Most of them had the phage-typing pattern 84/85, 84, or 85.

Full text

PDF
708

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Brumfitt W., Faiers M. C., Pursell R. E., Reeves D. S., Turnbull A. R. Bacteriological, pharmacological and clinical studies with trimethoprim-sulphonamide combinations with particular reference to the treatment of urinary infections. Postgrad Med J. 1969 Nov;45(Suppl):56–61. [PubMed] [Google Scholar]
  2. Craven J. L., Pugsley D. J., Blowers R. Trimethoprim-sulphamethoxazole in acute osteomyelitis due to penicillin-resistant staphylococci in Uganda. Br Med J. 1970 Jul 25;3(5716):201–203. doi: 10.1136/bmj.3.5716.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Darrell J. H., Garrod L. P., Waterworth P. M. Trimethoprim: laboratory and clinical studies. J Clin Pathol. 1968 Mar;21(2):202–209. doi: 10.1136/jcp.21.2.202. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Garrod L. P. The possible scope of trimethoprim-sulphonamide treatment. Postgrad Med J. 1969 Nov;45(Suppl):52–55. [PubMed] [Google Scholar]
  5. Garrod L. P., Waterworth P. M. Tests of bacterial sensitivity to drugs. Dis Mon. 1971 Jul;:1–48. [PubMed] [Google Scholar]
  6. Goldie D. J., Alder V. G., Gillespie W. A. Changes in the drug resistance of Staphylococcus aureus in a non-hospital population during a 20-year period. J Clin Pathol. 1971 Feb;24(1):44–47. doi: 10.1136/jcp.24.1.44. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hughes D. T. Treatment of exacerbations of chronic chest infections with combinations of sulphamethoxazole4trimethoprim (including comparison with ampicillin). Postgrad Med J. 1969 Nov;45(Suppl):86–88. [PubMed] [Google Scholar]
  8. JEVONS M. P., PARKER M. T. THE EVOLUTION OF NEW HOSPITAL STRAINS OF STAPHYLOCOCCUS AUREUS. J Clin Pathol. 1964 May;17:243–250. doi: 10.1136/jcp.17.3.243. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Jevons M. P., John M., Parker M. T. Cultural characters of a newly recognized group of hospital staphylococci. J Clin Pathol. 1966 Jul;19(4):305–312. doi: 10.1136/jcp.19.4.305. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lacey R. W., Bruten D. M., Gillespie W. A., Lewis E. L. Trimethoprim-resistant coliforms. Lancet. 1972 Feb 19;1(7747):409–410. doi: 10.1016/s0140-6736(72)90857-4. [DOI] [PubMed] [Google Scholar]
  11. O'Grady F., Chamberlain D. A., Stark J. E., Cattell W. R., Sardeson J. M., Fry I. F., Spiro F. I., Waters A. H. Long-term, low-dosage, trimethoprim-sulphonamide in the control of chronic bacteriuria. Postgrad Med J. 1969 Nov;45(Suppl):61–64. [PubMed] [Google Scholar]

Articles from Journal of Clinical Pathology are provided here courtesy of BMJ Publishing Group

RESOURCES