Abstract
Comparison of the brain weight/liver weight ratio1 with the body weight of 95 stillborn and neonatally deceased infants of gestation 25-42 weeks shows that in appropriately grown infants the mean value ratio is 2·8 and is unchanged with increasing maturity. The normal range is 1·7-4·1. Survival time has no significant effect on the ratio as studied in this necropsy population. Dysmature infants of body weight less than 1 SD below the mean body weight for gestation are characterized by a brain: liver weight ratio of 4·5 or more. On the basis of these observations the brain: liver weight ratio may be employed as a guide to the prenatal nutrition of infants at necropsy.
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Selected References
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- BABSON S. G., KANGAS J., YOUNG N., BRAMHALL J. L. GROWTH AND DEVELOPMENT OF TWINS OF DISSIMILAR SIZE AT BIRTH. Pediatrics. 1964 Mar;33:327–333. [PubMed] [Google Scholar]
- CHURCHILL J. A. THE RELATIONSHIP BETWEEN INTELLIGENCE AND BIRTH WEIGHT IN TWINS. Neurology. 1965 Apr;15:341–347. doi: 10.1212/wnl.15.4.341. [DOI] [PubMed] [Google Scholar]
- Davies P. A., Davis J. P. Very low birth-weight and subsequent head growth. Lancet. 1970 Dec 12;2(7685):1216–1219. doi: 10.1016/s0140-6736(70)92180-x. [DOI] [PubMed] [Google Scholar]
- Dobbing J. Undernutrition and the developing brain. The relevance of animal models to the human problem. Am J Dis Child. 1970 Nov;120(5):411–415. doi: 10.1001/archpedi.1970.02100100075005. [DOI] [PubMed] [Google Scholar]
- Fishman M. A., Prensky A. L., Dodge P. R. Low content of cerebral lipids in infants suffering from malnutrition. Nature. 1969 Feb 8;221(5180):552–553. doi: 10.1038/221552a0. [DOI] [PubMed] [Google Scholar]
- GRUENWALD P. CHRONIC FETAL DISTRESS AND PLACENTAL INSUFFICIENCY. Biol Neonat. 1963;5:215–265. doi: 10.1159/000239870. [DOI] [PubMed] [Google Scholar]
- LUBCHENCO L. O., HANSMAN C., DRESSLER M., BOYD E. INTRAUTERINE GROWTH AS ESTIMATED FROM LIVEBORN BIRTH-WEIGHT DATA AT 24 TO 42 WEEKS OF GESTATION. Pediatrics. 1963 Nov;32:793–800. [PubMed] [Google Scholar]
- Myers R. E., Hill D. E., Holt A. B., Scott R. E., Mellits E. D., Cheek D. B. Fetal growth retardation produced by experimental placental insufficiency in the rhesus monkey. I. Body weight, organ size. Biol Neonate. 1971;18(5):379–394. doi: 10.1159/000240380. [DOI] [PubMed] [Google Scholar]
- NAEYE R. L. MALNUTRITION: PROBABLE CAUSE OF FETAL GROWTH RETARDATION. Arch Pathol. 1965 Mar;79:284–291. [PubMed] [Google Scholar]
- Neumann G. J. The determination of normal ranges from routine laboratory data. Clin Chem. 1968 Oct;14(10):979–988. [PubMed] [Google Scholar]
- Rosso P., Hormazábal J., Winick M. Changes in brain weight, cholesterol, phospholipid, and DNA content in marasmic children. Am J Clin Nutr. 1970 Oct;23(10):1275–1279. doi: 10.1093/ajcn/23.10.1275. [DOI] [PubMed] [Google Scholar]
- Shelley H. J., Neligan G. A. Neonatal hypoglycaemia. Br Med Bull. 1966 Jan;22(1):34–39. doi: 10.1093/oxfordjournals.bmb.a070433. [DOI] [PubMed] [Google Scholar]
- WIGGLESWORTH J. S. EXPERIMENTAL GROWTH RETARDATION IN THE FOETAL RAT. J Pathol Bacteriol. 1964 Jul;88:1–13. [PubMed] [Google Scholar]
- Wigglesworth J. S. Foetal growth retardation. Br Med Bull. 1966 Jan;22(1):13–15. doi: 10.1093/oxfordjournals.bmb.a070429. [DOI] [PubMed] [Google Scholar]
- Winick M. Cellular growth during early malnutrition. Pediatrics. 1971 Jun;47(6):969–978. [PubMed] [Google Scholar]
- Winick M., Rosso P. Head circumference and cellular growth of the brain in normal and marasmic children. J Pediatr. 1969 May;74(5):774–778. doi: 10.1016/s0022-3476(69)80140-x. [DOI] [PubMed] [Google Scholar]