Abstract
A rapid gas-chromatographic method has been developed for the determination of butobarbitone, amylobarbitone, hexabarbitone, pentobarbitone, quinalbarbitone, phenobarbitone glutethimide, and methaqualone in `finger-prick' samples of plasma. This has been applied to the analysis of some of these drugs in plasma taken from patients after therapeutic dosage and over-dosage.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anders M. W. Rapid micromethod for gas chromatographic determination of blood barbiturates. Anal Chem. 1966 Dec;38(13):1945–1947. doi: 10.1021/ac50155a074. [DOI] [PubMed] [Google Scholar]
- Berry D. J. Gas chromatographic determination of methaqualone, 2-methyl-3-o-tolyl-4(3H)-quinazolinone, at therapeutic levels in human plasma. J Chromatogr. 1969 Jun 3;42(1):39–44. doi: 10.1016/s0021-9673(01)80585-9. [DOI] [PubMed] [Google Scholar]
- Leach H., Toseland P. A. The determination of barbiturates and some related drugs by gas chromatography. Clin Chim Acta. 1968 May;20(2):195–203. doi: 10.1016/0009-8981(68)90151-4. [DOI] [PubMed] [Google Scholar]
- MacGee J. Rapid identification and quantitative determination of barbiturates and glutethimide in blood by gas-liquid chromatography. Clin Chem. 1971 Jul;17(7):587–591. [PubMed] [Google Scholar]
- McMartin C., Street H. V. Gas-liquid chromatography of submicrogram amounts of drugs. II. Analysis of barbiturates and related drugs in biological media. J Chromatogr. 1966 Jul;23(2):232–241. doi: 10.1016/s0021-9673(01)98678-9. [DOI] [PubMed] [Google Scholar]
- REITH J. F., VAN DER HEIDE R. F., ZWAAL R. F. HERKENNING EN BEPALING VAN BARBITALEN IN BLOED DOOR MIDDEL VAN GASCHROMATOGRAFIE. Pharm Weekbl. 1965 Feb 12;100:219–227. [PubMed] [Google Scholar]
- STREET H. V., MCMARTIN C. QUANTITATIVE ESTIMATION AND IDENTIFICATION OF BARBITURATES IN BLOOD IN EMERGENCY CASES. Nature. 1963 Aug 3;199:456–459. doi: 10.1038/199456a0. [DOI] [PubMed] [Google Scholar]