Figure 3.

In vivo toxicity of NAP9. A. Mice were injected with NAP9 at the dosages shown. After 10 days, plasma levels of hepatic alanine transaminase (ALT), aspartate transaminase (AST), creatinine (Crea) and creatinine kinase (CK-MB) were measured. (n=9 mice). B. Tissue distribution of 50 mg/Kg NAP9 in the same mice as before, as detected by confocal microscopy. Right. Confocal microscopy visualization of endogenous EMMPRIN (green) and NAP9 (red) in crossed sections of pulmonary tissue. Merged plane shows co-localization of both signals in yellow.