Abstract
We have investigated the incidence of antibodies to food antigens in patients with recurrent minor aphthous ulceration and in patients with other oral ulcerative diseases. The incidence of these antibodies was the same in both groups of patients and was significantly greater than the incidence in a control group of normal people. There was no evidence to support the hypothesis that aphthous ulceration is primarily due to hypersensitivity to food antigens. The factors which might contribute to the absorption of antigenic molecules from the mouth and to the increased immune response in patients with oral disease have been considered.
Full text
PDF



Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BOYDEN S. V. The adsorption of proteins on erythrocytes treated with tannic acid and subsequent hemagglutination by antiprotein sera. J Exp Med. 1951 Feb;93(2):107–120. doi: 10.1084/jem.93.2.107. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Bayless T. M., Partin J. S., Partin J. C. Serum precipitins to milk, gluten and rice in tropical sprue. Johns Hopkins Med J. 1967 May;120(5):310–316. [PubMed] [Google Scholar]
- Beckwith A. C., Heiner D. C. An immunological study of wheat gluten proteins and derivatives. Arch Biochem Biophys. 1966 Nov;117(2):239–247. doi: 10.1016/0003-9861(66)90408-5. [DOI] [PubMed] [Google Scholar]
- Buckley R. H., Dees S. C. Correlation of milk precipitins with IgA deficiency. N Engl J Med. 1969 Aug 28;281(9):465–469. doi: 10.1056/NEJM196908282810903. [DOI] [PubMed] [Google Scholar]
- CROWLE A. J. A simplified micro double-diffusion agar precipitin technique. J Lab Clin Med. 1958 Nov;52(5):784–787. [PubMed] [Google Scholar]
- Ferguson A., Carswell F. Precipitins to dietary proteins in serum and upper intestinal secretions of coeliac children. Br Med J. 1972 Jan 8;1(5792):75–77. doi: 10.1136/bmj.1.5792.75. [DOI] [PMC free article] [PubMed] [Google Scholar]
- HOLLAND N. H., HONG R., DAVIS N. C., WEST C. D. Significance of precipitating antibodies to milk proteins in the serum of infants and children. J Pediatr. 1962 Aug;61:181–195. doi: 10.1016/s0022-3476(62)80252-2. [DOI] [PubMed] [Google Scholar]
- Huntley C. C., Robbins J. B., Lyerly A. D., Buckley R. H. Characterization of precipitating antibodies to ruminant serum and milk proteins in humans with selective IgA deficiency. N Engl J Med. 1971 Jan 7;284(1):7–10. doi: 10.1056/NEJM197101072840102. [DOI] [PubMed] [Google Scholar]
- Lehner T. Characterization of mucosal antibodies in recurrent aphthous ulceration and Behcet's syndrome. Arch Oral Biol. 1969 Jul;14(7):843–853. doi: 10.1016/0003-9969(69)90174-5. [DOI] [PubMed] [Google Scholar]
- Lehner T. Immunoglobulin estimation of blood and saliva in human recurrent oral ulceration. Arch Oral Biol. 1969 Apr;14(4):351–364. doi: 10.1016/0003-9969(69)90089-2. [DOI] [PubMed] [Google Scholar]
- Mancini G., Carbonara A. O., Heremans J. F. Immunochemical quantitation of antigens by single radial immunodiffusion. Immunochemistry. 1965 Sep;2(3):235–254. doi: 10.1016/0019-2791(65)90004-2. [DOI] [PubMed] [Google Scholar]
- SIRCUS W., CHURCH R., KELLEHER J. Recurrent aphthous ulceration of the mouth; a study of the natural history, aetiology, and treatment. Q J Med. 1957 Apr;26(102):235–249. [PubMed] [Google Scholar]
- TAYLOR K. B., TRUELOVE S. C. Circulating antibodies to milk proteins in ulcerative colitis. Br Med J. 1961 Oct 7;2(5257):924–929. doi: 10.1136/bmj.2.5257.924. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TAYLOR K. B., TRUELOVE S. C., THOMSON D. L., WRIGHT R. An immunological study of coeliac disease and idiopathic steatorrhoea. Serological reactions to gluten and milk proteins. Br Med J. 1961 Dec 30;2(5269):1727–1731. doi: 10.1136/bmj.2.5269.1727. [DOI] [PMC free article] [PubMed] [Google Scholar]
- TAYLOR K. B., TRUELOVE S. C., WRIGHT R. SEROLOGIC REACTIONS TO GLUTEN AND COW'S MILK PROTEINS IN GASTROINTESTINAL DISEASE. Gastroenterology. 1964 Feb;46:99–108. [PubMed] [Google Scholar]
