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. Author manuscript; available in PMC: 2017 Mar 2.
Published in final edited form as: Neuron. 2016 Feb 18;89(5):1059–1073. doi: 10.1016/j.neuron.2016.01.023

Figure 5. CB1Rs on glutamatergic cells modulate temporal summation of excitatory inputs in SPCs.

Figure 5

A) Example traces (averages of ≥5) of EPSP trains evoked in SPCs and DPCs in WT mice in control conditions (CTR) and after bath application of WIN or AM251.

B,C) Summary data of EPSP summation and amplitude of first EPSPs in SPCs (B) and DPCs (C) in CTR and after WIN or AM251 application (n: CTR SPCs: 12; WIN SPCs: 12; AM251 SPCs: 15; CTR DPCs: 11; WIN DPCs: 14; AM251 DPCs: 11).

D) Traces of EPSP trains evoked in SPCs from GLU-CB1RKO mice in CTR and after WIN or AM251. Right: Summary data of EPSP summation and amplitude of first EPSPs (n: CTR: 15; WIN: 15; AM251: 14).

E, F) Summary data of EPSP summation and amplitude of first EPSPs in CB1R− SPCs (E) and in CB1R+ (F) in CTR and after WIN or AM251 (n: CTR CB1R− 10; WIN CB1R−: 10; AM251 CB1R−: 11; CTR CB1R+: 10; WIN CB1R+: 10; AM251 + CB1R+: 11).

G) Summary data of EPSP summation and amplitude of first EPSPs in SPCs from HCN1KOs in CTR and after WIN or AM251 (n: CTR: 9; WIN: 11; AM251: 11).

H) Summary data of EPSP summation and amplitude of first EPSPs in SPCs from ZD7288-treated slices in CTR and after WIN or AM251 application (n: CTR: 12; WIN: 14; AM251: 12).