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Journal of Clinical Pathology logoLink to Journal of Clinical Pathology
. 1973 Jun;26(6):401–404. doi: 10.1136/jcp.26.6.401

Bacterial contamination of platelet concentrates stored at 20°C

Margaret Cunningham 1, John D Cash 1
PMCID: PMC477769  PMID: 4578159

Abstract

Qualitative and quantitative data on the bacterial contamination of 1000 platelet concentrates prepared and stored at 20°C are presented. Using cooked meat medium the incidence of contamination was 6·3%. However, nutrient agar platelet counts showed the concentration of bacteria to be low. The clinical significance of these results is discussed.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BORDEN C. W., HALL W. H. Fatal transfusion reactions from massive bacterial contamination of blood. N Engl J Med. 1951 Nov 15;245(20):760–765. doi: 10.1056/NEJM195111152452003. [DOI] [PubMed] [Google Scholar]
  2. BRAUDE A. I., SANFORD J. P., BARTLETT J. E., MALLERY O. T., Jr Effects and clinical significance of bacterial contaminants in transfused blood. J Lab Clin Med. 1952 Jun;39(6):902–916. [PubMed] [Google Scholar]
  3. BRAUDE A. I., WILLIAMS D., SIEMENSKI J., MURPHY R. Shock-like state due to transfusion of blood contaminated with gram-negative bacilli; successful treatment with antibiotics and arterenol. AMA Arch Intern Med. 1953 Jul;92(1):75–84. doi: 10.1001/archinte.1953.00240190087006. [DOI] [PubMed] [Google Scholar]
  4. Buchholz D. H., Young V. M., Friedman N. R., Reilly J. A., Mardiney M. R., Jr Bacterial proliferation in platelet products stored at room temperature. Transfusion-induced Enterobacter sepsis. N Engl J Med. 1971 Aug 19;285(8):429–433. doi: 10.1056/NEJM197108192850803. [DOI] [PubMed] [Google Scholar]
  5. Clawson C. C., White J. G. Platelet interaction with bacteria. I. Reaction phases and effects of inhibitors. Am J Pathol. 1971 Nov;65(2):367–380. [PMC free article] [PubMed] [Google Scholar]
  6. Handin R. I., Valeri C. R. Hemostatic effectiveness of platelets stored at 22 degrees C. N Engl J Med. 1971 Sep 2;285(10):538–543. doi: 10.1056/NEJM197109022851003. [DOI] [PubMed] [Google Scholar]
  7. Katz A. J., Tilton R. C. Sterility of platelet concentrates stored at 25 C. Transfusion. 1970 Nov-Dec;10(6):329–330. doi: 10.1111/j.1537-2995.1970.tb00754.x. [DOI] [PubMed] [Google Scholar]
  8. Murphy S., Gardner F. H. Effect of storage temperature on maintenance of platelet viability--deleterious effect of refrigerated storage. N Engl J Med. 1969 May 15;280(20):1094–1098. doi: 10.1056/NEJM196905152802004. [DOI] [PubMed] [Google Scholar]
  9. Murphy S., Sayar S. N., Gardner F. H. Storage of platelet concentrates at 22 degrees C. Blood. 1970 Apr;35(4):549–557. [PubMed] [Google Scholar]
  10. STEVENS A. R., Jr, LEGG J. S., HENRY B. S., DILLE J. M., KIRBY W. M., FINCH C. A. Fatal transfusion reactions from contamination of stored blood by cold growing bacteria. Ann Intern Med. 1953 Dec;39(6):1228–1239. doi: 10.7326/0003-4819-39-6-1228. [DOI] [PubMed] [Google Scholar]
  11. Silver H., Sonnenwirth A. C., Beisser L. D. Bacteriologic study of platelet concentrates prepared and stored without refrigeration. Transfusion. 1970 Nov-Dec;10(6):315–316. doi: 10.1111/j.1537-2995.1970.tb00750.x. [DOI] [PubMed] [Google Scholar]
  12. WALTER C. W., KUNDSIN R. B., BUTTON L. N. New technic for detection of bacterial contamination in a blood bank using plastic equipment. N Engl J Med. 1957 Aug 22;257(8):364–369. doi: 10.1056/NEJM195708222570803. [DOI] [PubMed] [Google Scholar]

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